A5100390890- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Diabetes Management and Education
- Stress Responses and Cortisol
- Urinary Tract Infections Management
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Prostate Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- MicroRNA in disease regulation
- Cardiac Health and Mental Health
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Prostate Cancer Treatment and Research
- Heart rate and cardiovascular health
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Sodium Intake and Health
- Metabolism, Diabetes, and Cancer
Central South University
2013-2024
Third Xiangya Hospital
2023-2024
Xiangya Hospital Central South University
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Beijing Hospital
2022
Tianjin Medical University
2017
Shanghai Ninth People's Hospital
2017
Shanghai Institutes for Biological Sciences
2017
Chinese Academy of Sciences
2017
Center for Excellence in Molecular Cell Science
2017
Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells T-cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not elucidated.We aim determine role BP explore mechanism.Using knockout mouse combination with angiotensin II-induced hypertensive model, we demonstrated that deficiency strikingly...
Objective . This study is aimed at assessing the effectiveness of a simple outpatient diabetes self-management education programme. Methods In study, 60 patients with type 2 mellitus were randomly allocated into control group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>30</mml:mn></mml:math>) and intervention id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>30</mml:mn></mml:math>). Regular 2-session health programmes...
To emphasize the mechanism of effect exercise on lipid droplet (LD) metabolism disorder in nonalcoholic fatty liver disease (NAFLD). C57BL/6J mice were randomly divided into three groups: The first group was fed with a normal diet (CON), second high-fat (HF), and finally intervention swim training (HF-EX). total period 16 weeks. RT-PCR Western blot performed to evaluate LDs AMPK pathway. Histopathological examinations immunofluorescence deposition lipophagy liver. Exercise reduced steatosis...
Although antagonists of mineralocorticoid receptor (MR) have been widely used to treat heart failure, the underlying mechanisms are incompletely understood. Recent reports show that T cells play important roles in pathologic cardiac hypertrophy and failure. However, it is unclear whether how MR functions under these conditions. We found antagonist suppressed abdominal aortic constriction-induced decreased accumulation activation CD4+ CD8+ mouse heart. T-cell knockout mice manifested...
This prospective 2-year, single-center, randomized, placebo-controlled, open-label clinical trial was performed to evaluate the efficacy of low-dose testosterone undecanoate (TU) treatment on bone mineral density (BMD) and biochemical markers turnover in elderly male osteoporosis with low serum testosterone. A total 186 patients were randomized into three groups: TU (20 mg, per day), standard-dose (40 placebo group a 24-month followup. Since 6th month or since 12th followup throughout study,...
To explore facilitators and barriers to self-management engagement of Chinese people with poorly controlled type 2 diabetes.Purposive sampling method was used for recruitment. Semi-structured interview thematic analysis data collection analysis.Twenty-six semi-structured interviews were conducted. Poor blood glucose control introduced awareness susceptibility complications, while mental disorders could be concomitant. General knowledge about healthy lifestyle unhealthy habits impeded...
To explore whether type III prostatitis is related to bacterial infection by detecting the composition and function of microorganisms in expressed prostatic secretion (EPS) patients with chronic (CP) healthy people.According inclusion exclusion criteria, 57 subjects were included our study, divided into group, II group. 16s rRNA sequencing technique was used detect analyze microbial EPS each Additionally, metagenomics further different bacteria Data analysis performed bioinformatics...
Abstract Aims / Introduction Heart rate recovery ( HRR ) after exercise is considered to be a new index of autonomic dysfunction associated with cardiovascular disease and mortality. The present study aimed investigate the risk factors effects on abnormal in type 2 diabetes. Materials Methods A total 123 diabetes patients were recruited, oral glucose tolerance test carried out analyze . Among these patients, 42 further randomized either conventional therapy group CT group; n = 20) or...
Abstract To detect and analyze the changes of microorganisms in expressed prostatic secretion (EPS) patients with IIIB prostatitis before after low-intensity pulsed ultrasound (LIPUS) treatment, to explore mechanism LIPUS treatment chronic (CP). 25 (study power was estimated using a Dirichlet-multinomial approach reached 96.5% at α = 0.05 sample size 25) who were effective divided into two groups treatment. High throughput second-generation sequencing technique used relative abundance...
Background: Sotagliflozin (LX4211) is a dual inhibitor of sodium-glucose cotransporter (SGLT)1 and SGLT2 being investigated to improve glycemic control in adults with diabetes. This study was firstly conducted assess the pharmacokinetic (PK), pharmacodynamic (PD) profiles, safety tolerability Chinese healthy subjects after administration sotagliflozin. Methods: Phase I, randomized, double-blind, placebo-controlled, ascending multiple-dose study. Healthy received 200mg or 400mg sotagliflozin...
Objective To explore the status of iodine nutrition in 8～10 years children after universal salt iodization(USI)in deficiency area.Methods Probability proportion to size method(PPS)or simple random sampling methods were used sample aged area vear 1995,1997,1999,2002 and 2005, respectively.Goiter detected by palpation B-ultrasound, concentration was direct titration method that urine As3+-Ce4+catalytic spectrophotometry.Results After USI has been implemented,the median urinary tended...
Objective To investigate the status of iodine content and goiter rate residents in excessive intaking areas Dezhou Shandong Province after ceasing supplementation iodized salt. Methods In ten counties (cities, districts) from 2013 to 2014, 300 were selected each county (city, district) examine their household salt level. Five chosen as monitoring sites every year, which divided two groups according water levels (150 -300 > μg/L). One town that met requirement group was a test site,...
Objective To analyze the clinical characteristics of collagenous gastritis (CG) and provide evidence for precise diagnosis treatment CG.Methods Published case reports series were collected from PubMed,CNKI,and Wanfang Med Online with key words gastritis,collagenous gastroduodenitis,collagenous gastrointestinal diseases,and gastric mucosal nodules.The demographic information each was collected.Results According to extent collagen deposition in digestive tract,94 CG cases included this study...
Silodosin is a novel selective α1Α-adrenoceptor (AR) antagonist developed by Kissei Pharmaceutical Co. in Japan. It indicated for the treatment of signs and symptoms benign prostatic hype...