A5101404177- Systemic Lupus Erythematosus Research
- Corrosion Behavior and Inhibition
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Layered Double Hydroxides Synthesis and Applications
- Magnesium Alloys: Properties and Applications
- Salivary Gland Disorders and Functions
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Systemic Sclerosis and Related Diseases
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Gut microbiota and health
- Oral microbiology and periodontitis research
- Synthesis and Reactivity of Heterocycles
- Full-Duplex Wireless Communications
- Pregnancy and preeclampsia studies
- Autoimmune Bullous Skin Diseases
Viva Biotech (China)
2024
China West Normal University
2023-2024
Heilongjiang University of Chinese Medicine
2024
Pfizer (United States)
2017-2023
Central Hospital of Wuhan
2022
General Hospital of Central Theater Command
2022
Peking University People's Hospital
2019-2021
Peking University
2019-2021
Fudan University
2005-2021
Chongqing Medical University
2021
Abstract The activation of Wnt/β‐catenin pathway plays a pivotal role in promoting renal fibrosis. relies on the binding Wnts to Frizzled receptors cell membrane. However, factor regulating production remains unclear. Here, we demonstrated that transcriptional FoxM1 was significantly increased obstructed kidneys and patients' with up‐regulation mainly distributed tubular epithelial cells. Pharmacological inhibition down‐regulated multi‐Wnts elevation UUO mice attenuated In cultured cells,...
Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying bloodborne C. infection remains unclear. Herein, we evaluated gut microbiome, metabolites intestinal mucosa by constructing mouse models Model mice were injected via tail vein. Control underwent sham procedures....
Abstract Background This is the first report on effects of abrocitinib, a Janus kinase 1–selective inhibitor, expression skin biomarkers in patients with moderate‐to‐severe atopic dermatitis (AD). Methods JADE MOA (NCT03915496) was double‐blind Phase 2a trial. Adults were randomly assigned 1:1:1 to receive monotherapy once‐daily abrocitinib 200 mg, 100 or placebo for 12 weeks. The primary endpoint change from baseline markers inflammation (matrix metalloproteinase [MMP]‐12), epidermal...
Abstract Progressive tubulointerstitial fibrosis is the common final outcome for all kidney diseases evolving into chronic disease (CKD), whereas molecular mechanisms driving fibrogenesis remain elusive. Retinoic acid-inducible gene-I (RIG-I), an intracellular pattern recognition receptor, originally identified participating in immune response by recognizing virus RNA. Here, we revealed first time that RIG-I was induced unilateral ureteral obstruction (UUO) and folic acid (FA) renal models...
Proteinuria, the most common symptom of renal injury, is an independent factor for tubular injury. However, underlying mechanism remains to be fully elucidated. Mitochondrion important target proteinuria-induced cell Insufficient mitophagy exacerbates injury by initiating mitochondrial dysfunction-related apoptosis. In experiment, role NIP3-like protein X (NIX)-mediated was investigated in this study, we demonstrated that NIX expression reduced tubules and correlated with decline estimated...
Renal tubular injury is the hallmark of cisplatin-induced nephrotoxicity. Caspase-11, a member caspase family, plays an important role in inflammation and cell death. However, its renal remains unclear. In cisplatin-treated mice, caspase-11 expression was significantly elevated mainly located tubule. Inhibition by small-interference RNA or inhibitor wedelolactone attenuated dysfunction injury. cultured primary epithelial cells, cisplatin promoted activation caspase-11. reduced apoptosis....
Abstract Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with high mortality rate, while polyomavirus (MCV) has been pointed as the causative agent of MCC. A better prognosis MCC associated level antibodies against capsid protein VP1 suggests that anti-VP1 immune response might be essential growth. In current study, we developed VP1-target vaccine formulated CRA. Using tumorigenic CMS5-VP1 tumor model, vaccine-induced potent antitumor efficacy in dose-dependent manner was...
Antimicrobial de-escalation refers to starting the antimicrobial treatment with broad-spectrum antibiotics, followed by narrowing drug spectrum according culture results. The present study evaluated effect of on ventilator-associated pneumonia (VAP) in trauma patients.This retrospective was conducted patients VAP, who received therapy (de-escalation group) or non-de-escalation (non-de-escalation group). Propensity score matching method used balance baseline characteristics between both...
Objective To guide clinical decision making, race-, age- and gender-specific reference ranges for lymphocytes CD4+ T-cell subsets are required. Methods Single platform flow cytometry to determine intervals lymphocyte subpopulations in 196 healthy Han Chinese adults. Results The frequencies absolute numbers of B cells were slightly lower individuals the Shanxi region than from Hong Kong, Germany Singapore, while percentages NK higher compared with Kong. CD4+/CD8+ ratios, T cell Th2 counts...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple autoantibody production and often affects the kidneys, known as nephritis. However, mechanism underlying nephritis development unclear. Biofilms that protect bacteria from stress are ubiquitous in almost every environment. Here, we identified conserved peptide (HU1) derived DNABII proteins, one of major bacterial biofilm components, was specifically recognized by sera about 47% patients SLE. Moreover, serum...