A5084582460- Plant biochemistry and biosynthesis
- Cervical and Thoracic Myelopathy
- Research in Cotton Cultivation
- Plant Stress Responses and Tolerance
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Plant Molecular Biology Research
- Pharmacological Effects of Natural Compounds
- Analytical Methods in Pharmaceuticals
- Photosynthetic Processes and Mechanisms
- MicroRNA in disease regulation
- Nerve Injury and Rehabilitation
- SARS-CoV-2 detection and testing
- Plant tissue culture and regeneration
- Circular RNAs in diseases
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Microbial Natural Products and Biosynthesis
- Antibiotics Pharmacokinetics and Efficacy
- Glycosylation and Glycoproteins Research
- Pain Mechanisms and Treatments
- Enzyme Catalysis and Immobilization
- Spine and Intervertebral Disc Pathology
- Peripheral Nerve Disorders
Sichuan University
2014-2025
West China Hospital of Sichuan University
2009-2025
Hainan Normal University
2018-2025
Xinjiang Production and Construction Corps
2021-2024
Shihezi University
2016-2024
Huaihua University
2024
Chongqing Medical University
2017-2023
Kunming Medical University
2019-2023
Sixth Affiliated Hospital of Kunming Medical University
2019-2023
MRC Laboratory of Molecular Biology
2023
Polydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms in vitro vivo models. IgE-mediated passive cutaneous anaphylaxis (PCA) systemic (PSA) models were used to confirm PD effect vivo. Various signaling pathway proteins mast cell examined. RT-PCR, ELISA western blotting applied when appropriate. Activity of Lyn Fyn kinases was measured using the Kinase Enzyme System. dose-dependently reduced pigmentation Evans blue PCA model decreased...
Lipid accumulation by oleaginous microorganisms is of great scientific interest and biotechnological potential. While nitrogen limitation has been routinely employed, low-cost raw materials usually contain rich nitrogenous components, thus preventing from efficient lipid production. Inorganic phosphate (Pi) found sufficient to promote conversion sugars into lipids, yet the molecular basis cellular response Pi concurrent remains elusive. Here, we performed multi-omic analyses yeast...
Although cancer cells are frequently faced with a nutrient- and oxygen-poor microenvironment, elevated hexosamine-biosynthesis pathway (HBP) activity protein O-GlcNAcylation (a nutrient sensor) contribute to rapid growth of tumor emerging hallmarks cancer. Inhibiting could be promising anticancer strategy. The gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1 (PCK1) is downregulated in hepatocellular carcinoma (HCC). However, little known about the potential role PCK1 enhanced HBP HCC...
Ferroptosis is an iron-dependent form of cell death driven by biochemical processes that promote oxidation within the lipid compartment. Calcium (Ca2+) a signaling molecule in diverse cellular such as migration, neurotransmission, and death. Here, we uncover crucial link between ferroptosis Ca2+ through identification novel tetraspanin MS4A15. MS4A15 localizes to endoplasmic reticulum, where it blocks depleting luminal stores reprogramming membrane phospholipids ferroptosis-resistant...
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that gluconeogenic enzyme PCK1 fueled generation of S-adenosylmethionine (SAM) through serine synthesis pathway. The methyltransferase SUV39H1 catalyzed SAM, which served as methyl donor to support H3K9me3 modification, leading suppression oncogene S100A11. Mechanistically, deficiency-induced oncogenic activation S100A11 was due its...
Abstract Ethylene is a stimulant to increase natural rubber latex. After ethylene application, both fresh yield and dry matter of latex are substantially improved. Moreover, we found that improves the generation small particles. However, most genes involved in biosynthesis inhibited by exogenous ethylene. Therefore, conducted proteomics analysis ethylene-stimulated identified 287 abundant proteins as well 143 responsive (ERLPs) with mass spectrometry from 2-DE DIGE gels, respectively. In...
Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexpression of PCK1 has been shown to suppress liver growth, but underlying mechanism remains unclear. mRNA protein expression patterns PCK1, AMPK, pAMPK, CDK/Rb/E2F pathway were determined using qRT-PCR western blotting....
Ascorbate peroxidase (APX) is a member of heme-containing peroxidases which catalyze the H2O2-dependent oxidation wide range substrates in plants and animals. As known, H2O2 acts as signaling molecule regulation fiber development. Our previous work reported that ascorbate 1 (GhAPX1) was important for cotton elongation. However, knowledge about APX gene family members their evolutionary functional characteristics limited. Here, we report 26 GhAPX genes by genome-wide investigation tetraploid...
Abstract Background The aim of this study was to gain further investigation non-small cell lung cancer (NSCLC) tumorigenesis and identify biomarkers for clinical management patients through comprehensive bioinformatics analysis. Methods miRNA mRNA microarray datasets were downloaded from GEO (Gene Expression Omnibus) database under the accession number GSE102286 GSE101929, respectively. Genes miRNAs with differential expression identified in NSCLC samples compared controls, interaction...
Abstract Cassava is one of the most important root crops as a reliable source food and carbohydrates. Carbohydrate metabolism starch accumulation in cassava storage cascade process that includes large amounts proteins cofactors. Here, comparative proteomics were conducted at nine developmental stages. A total 154 identified found to be differentially expressed during tuberization. Many enzymes involved sucrose significantly up-regulated functional classification demonstrated majority...
// Xiang Jin 1 , Yinghui Guan Hui Sheng and Yang Liu Department of Respiration, The First Hospital Jilin University, Changchun City, Province, 130021, China Correspondence to: Guan, email: yhghope12@163.com Keywords: crosstalk, ceRNA network, lung cancer, molecular mechanism, circRNA-seq Received: March 29, 2017     Accepted: July 16, Published: August 24, 2017 ABSTRACT We investigated the transcriptional mechanism underlying cancer development. RNA sequencing analysis...
Gluconeogenesis, generates glucose from small carbohydrate substrates and drives the metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK-C), a rate-limiting enzyme gluconeogenesis, initiates gluconeogenesis process is reportedly dysregulated multiple types cancer. Gluconeogenesis mainly occurs liver during fasting, previous studies have demonstrated that PCK1 acts as tumor suppressor hepatocellular carcinoma...
Article28 June 2019Open Access Source DataTransparent process GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone Fan Yang Key Laboratory Molecular Biology for Infectious Diseases (Ministry Education), Department Diseases, The Second Affiliated Hospital, Institute Viral Hepatitis, Chongqing Medical University, Chongqing, China First Search more papers by this author Jingjing Li Haijun Deng Yihao Wang State Proteomics, Beijing Proteome...
To establish a clinician-led guideline for the diagnosis and treatment of Hirayama disease (HD) using modified Delphi technique.Based on combination systematic review opinion ten experts, protocol consensus diagnosis, follow-up assessment HD was established. A 3-round survey then performed by more than 40 panelists from various countries world. Both levels evidence agreement were derived in all statements finial guideline.A total 47 experts 6 enrolled expert panel this study. Highly...
Abstract Aberrant glucose metabolism and elevated O-linked β- N -acetylglucosamine modification (O-GlcNAcylation) are hallmarks of hepatocellular carcinoma (HCC). Loss phosphoenolpyruvate carboxykinase 1 (PCK1), the major rate-limiting enzyme hepatic gluconeogenesis, increases hexosamine biosynthetic pathway (HBP)-mediated protein O-GlcNAcylation in hepatoma cell promotes growth proliferation. However, whether PCK1 deficiency hyper can induce HCC metastasis is largely unknown. Here, gain-...
Verticillium wilt (VW), caused by species, is one of the most severe soil-borne plant diseases globally and has been ranked as world's top quarantine concerns. Over 400 species including crops are severely affected VW which results in significantly reduction yield quality, causing a substantial economic loss billions dollars worldwide. Controlling key pathogens always significant challenge hot concern (Chen et al., 2021; Wang 2020). Elucidating mechanisms pathogen–host interactions provides...
Taraxacum kok-saghyz (TKS) is a natural rubber (NR)-producing plant with great development prospects. Accurately understanding the molecular mechanism of biosynthesis significance. Cis-prenyltransferase (CPT) and cis-prenyltransferase-like (CPTL) proteins catalyze elongation chains play an essential role in biosynthesis. In this study, we performed genome-wide identification TkCPT/CPTL family, eight CPT two CPTL members. We analyzed gene structures, evolutionary relationships expression...
Neutrophil-to-lymphocyte ratio (NLR) can be treated as a simple indicator of patients' immune status by representing the state systemic inflammatory response. Immunotherapy now is accepted second-line treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). However, significance NLR in patients with R/M NPC undergoing PD-L1 (programmed cell death-ligand 1) inhibitors still uncertain. We analyzed relationship between baseline 153 efficacy and survival from multicenter,...
As the rapid growth of commercialized acreage in genetically modified (GM) crops, unintended effects GM crops' biosafety assessment have been given much attention. To investigate whether transgenic events cause effects, comparative proteomics cotton leaves between commercial Bt + CpTI SGK321 (BT) clone and its non-transgenic parental counterpart SY321 wild type (WT) was performed.Using enzyme linked immunosorbent assay (ELISA), Cry1Ac toxin protein detected BT leaves, while content only 0.31...
Hirayama disease (HD), amyotrophic lateral sclerosis (ALS) or cervical spondylotic amyotrophy (CSA) may result in atrophy of intrinsic hand and forearm muscles. The incidence HD is low, it rarely encountered the clinical setting. Consequently, often misdiagnosed as ALS CSA. It important to differentiate these diseases because caused by a benign focal lesion that limited upper limbs. thenar hypothenar compound muscle action potential (CMAP) amplitude limbs 100 HD, 97 32 CSA cases were...