A5100359074- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
- Head and Neck Cancer Studies
- Metastasis and carcinoma case studies
- Cardiac Ischemia and Reperfusion
- Multiple and Secondary Primary Cancers
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Neuroscience and Neuropharmacology Research
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
Sichuan University
2016-2025
West China Second University Hospital of Sichuan University
2022-2025
State Key Laboratory of Oral Diseases
2021-2024
West China Hospital of Sichuan University
2020-2024
Guangzhou University of Chinese Medicine
2024
Henan University of Science and Technology
2024
Hangzhou City University
2024
National Natural Science Foundation of China
2020-2024
Weatherford College
2020-2024
Guang’anmen Hospital
2024
The human body's primary line of defense, the skin, is especially prone to harm. Although microRNA (miRNA)-based therapies have attracted increasing attention for skin wound healing, their applications remain limited owing a range issues. Tetrahedral framework DNA (tFNA), nanomaterial possessing nucleic acid characteristics, exhibits an excellent biocompatibility, in addition anti-inflammatory and transdermal delivery capabilities, can accelerate healing. Due its potential exert synergistic...
Background Systemic sclerosis (SSc) is a rare disabling connective tissue disease with few available treatment options. Diffuse cutaneous systemic (dcSSc) associated high mortality. A previous experiment has shown that JAK2 inhibitor can significantly improve skin fibrosis in bleomycin (BLM)-induced murine model, including reducing dermal thickening and collagen accumulation. We aimed to describe the efficacy of oral JAK1/2 baricitinib SSc patients, especially focusing on microvascular...
Immune checkpoint inhibitors (ICIs) show optimal treatment effects on recurrent or metastatic nasopharyngeal carcinoma(R/M NPC). Nonetheless, whether sites impact ICIs efficacy remains unclear. We performed a secondary analysis of R/M NPC patients treated with KL-A167, programmed cell death-ligand 1(PD-L1) inhibitor, based multicenter, single-arm, phase II study from China between 2019 and 2021 years, which represents the first most comprehensive effectiveness PD-L1 inhibitor in who have...
Neutrophil-to-lymphocyte ratio (NLR) can be treated as a simple indicator of patients' immune status by representing the state systemic inflammatory response. Immunotherapy now is accepted second-line treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). However, significance NLR in patients with R/M NPC undergoing PD-L1 (programmed cell death-ligand 1) inhibitors still uncertain. We analyzed relationship between baseline 153 efficacy and survival from multicenter,...
Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 inhibitors, have demonstrated significant survival benefits in treating recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC). While baseline peripheral blood lymphocyte subsets been identified as prognostic biomarkers various cancers treated with ICIs, their relevance R/M-NPC has not extensively studied. This post hoc analysis used data from 153 patients PD-L1 inhibitor monotherapy the phase 2 trial KL167-2-05-CTP. The...
Penile Squamous Cell Carcinoma (SCC) is a rare cancer with poor prognosis and limited response to conventional chemotherapy. The genetic epigenetic alterations of Epidermal Growth Factor Receptor (EGFR)-RAS-RAF signaling in penile SCC are unclear. This study aims investigate four key members this pathway SCC. We examined the expression EGFR RAS-association domain family 1 A (RASSF1A) as well mutation status K-RAS BRAF 150 cases RASSF1A was evaluated by immunohistochemistry. KRAS mutations at...
Growing evidence indicates that the tumor microenvironment (TME) can be combined with other therapeutic modalities, including cytotoxic chemotherapy and targeted therapies, to produce unanticipated results in oncology treatment. Here, we proposed a novel bacterial nanomaterial capable of targeting peritumoral biofilm modulating TME. It was based on tetrahedral framework nucleic acids (T) were chemically attached aptamer AS1411 5-fluorouracil (AT5). Additionally, oral pathogenic bacterium...
Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder associated with a predisposition to variety of cancers. Previous studies that have evaluated the cancer spectrum and risk this rare disease primarily been based on small data sets or heterogeneous cohorts from different countries. Here, we report results large homogeneous cohort Chinese PJS patients who were followed prospectively 2006 July 2021, clinical before retrospectively collected. A total 412 (56.55% males) 208...
Alcoholic liver disease (ALD) poses a substantial global health challenge, with its pathogenesis deeply rooted in mitochondrial dysfunction.Our study explores the pivotal roles of Phosphoglycerate mutase family member 5 (Pgam5) and Voltage-Dependent Anion Channel 1 (VDAC1) progression ALD, providing novel insights into their interplay impact on integrity.We demonstrate that Pgam5 silencing preserves hepatocyte viability attenuates ethanol-induced apoptosis, underscoring detrimental role...
Abstract Background Effective systemic therapy remains limited for advanced esophageal squamous cell carcinoma (ESCC) and hepatocellular (HCC), particularly after prior failed treatment with immune checkpoint inhibitors (ICIs). Theoretically, a combination of tyrosine kinase (TKIs) ICIs may restore immunotherapy sensitivity. Methods In this phase 1b study, patients received AL2846, an antiangiogenic TKI multiple targets (c‐MET, VEGFR1, c‐KIT, Axl, RET, KDR, VEGFR3), in anti–PD‐L1 antibody...
Osteoarthritis (OA) is a chronic, degenerative joint disease presenting significant global health threat. While current therapeutic approaches primarily target symptom relief, their efficacy in repairing damage remains limited. Recent research has highlighted mesenchymal stem cells (MSCs) as potential contributors to cartilage repair, anti-inflammatory modulation, and immune regulation OA patients. Notably, MSCs from different sources derivatives exhibit variations effectiveness treating OA....
Frailty refers to a decline in the physiological functioning of one or more organ systems. It remained unclear whether variations trajectory frailty over time were associated with subsequent cognitive change. The aim current study was investigate association between trajectories and based on Health Retirement Study (HRS). A total 15,454 participants included. assessed using Paulson-Lichtenberg Index, while function evaluated Langa-Weir Classification. Results showed that severe significantly (
Pkd2l2 is a novel member of the polycystic kidney disease (PKD) gene family in mammals. Prominently expressed testis, this still poorly understood. In study, reverse transcription polymerase chain reaction (RT-PCR) results showed time-dependent expression pattern postnatal mouse testis. Immunohistochemical analysis revealed that encoded protein, polycystin-L2, which was predominantly detectable plasma membrane spermatocytes and round spermatids, as well head tail elongating spermatids within...
Neoadjuvant chemoradiation or chemotherapy has improved the treatment efficacy of patients with resectable, borderline and locally advanced pancreatic ductal adenocarcinoma (PDAC). Due to optimal regimen remains inconclusive, we aimed compare these treatments in terms margin negative (R0) resection rate overall survival (OS) Bayesian analysis.We reviewed literature titles abstracts comparing three strategies (neoadjuvant chemoradiation, neoadjuvant chemotherapy, upfront surgery) PubMed,...
Abstract Studies have shown that polycystin‐1, encoded by PKD1, the major ADPKD, may a central role in regulating both apoptosis and proliferation, which could prevent malignant transformation of affected cells. However, as putative tumor suppressor, direct studies on possibility polycystin‐1 play cancer cells' biological properties not yet been reported. We demonstrated cells was induced overexpression polycystin‐1. After transfection with three cell lines, HepG2, A549, SW480, showed...
The RAS-association domain family 1 A (RASSF1A) is a classical member of RAS effectors regulating cell proliferation and apoptosis. Loss RASSF1A expression may shift the balance towards growth-promoting effect without necessity activating K-ras mutations. Its potential association with mutations in colorectal cancer (CRC) unclear.RASSF1A was examined normal mucosa, adenoma, tumor tissues colon rectum, respectively. We expression, K-ras, EGFR status 76 primary CRCs. relationship between...
Abstract Lessons Learned The upregulation of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) are important mechanisms resistance to 5-fluorouracil (5-FU) in metastatic colorectal cancer (mCRC) after long exposure 5-FU. S-1 (containing a DPD inhibitor) combined with raltitrexed (a TS showed moderate effect, which needs further study as third- or later-line therapy mCRC. Background is fundamental drug the treatment (mCRC). Patients mCRC often exposed 5-FU and/or its...