A5034208871- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Histiocytic Disorders and Treatments
- Genetic and rare skin diseases.
- Urticaria and Related Conditions
- Nonmelanoma Skin Cancer Studies
- Skin and Cellular Biology Research
- Skin Diseases and Diabetes
- Parvovirus B19 Infection Studies
- Fungal Infections and Studies
- Inflammatory Myopathies and Dermatomyositis
- Viral-associated cancers and disorders
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders
- Hedgehog Signaling Pathway Studies
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Hidradenitis Suppurativa and Treatments
- Dermatologic Treatments and Research
- Wnt/β-catenin signaling in development and cancer
- IgG4-Related and Inflammatory Diseases
- Toxin Mechanisms and Immunotoxins
- Mast cells and histamine
Southern Medical University
2017-2024
Guangdong Provincial People's Hospital
2014-2020
Anhui Medical University
2019
Ackerman Academy of Dermatopathology
2015-2017
Medical University of South Carolina
2016
Guangdong Provincial Center for Disease Control and Prevention
2010-2013
Background Systemic sclerosis (SSc) is a rare disabling connective tissue disease with few available treatment options. Diffuse cutaneous systemic (dcSSc) associated high mortality. A previous experiment has shown that JAK2 inhibitor can significantly improve skin fibrosis in bleomycin (BLM)-induced murine model, including reducing dermal thickening and collagen accumulation. We aimed to describe the efficacy of oral JAK1/2 baricitinib SSc patients, especially focusing on microvascular...
Abstract Background Nuclear pleomorphism and tumor microenvironment (TME) play a critical role in cancer development progression. Identifying most predictive nuclei TME features of basal cell carcinoma (BCC) may provide insights into which characteristics pathologists can use to distinguish stratify this entity. Objectives To develop an automated workflow based on from basaloid regions differentiate BCC trichoepithelioma (TE) high‐risk (HR) low‐risk (LR) subtypes, identify the nuclear...
Rationale: Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, skin fibrosis one of distinguishing hallmarks in the pathogenesis.However, macrophage heterogeneity regulating remain largely unknown.Methods: We established mouse model performed single-cell RNA-sequencing (scRNA-seq) to resolve dynamic heterogenous characteristics macrophages fibrosis, role TREM2-dependent pathological process was investigated using knockout mice intraperitoneal...
Persistent pruritic eruptions (PPEs), presenting with dyskeratotic keratinocytes histologically, are characteristic skin rash in patients adult-onset Still's disease (AOSD). The lesions may be histologically similar to other entities that present dyskeratosis. In the study, we compared histopathological features between PPEs and dyskeratosis.To investigate whether findings can used discriminate among keratinocytes, cutaneous changes of associated AOSD (n = 26) were those systemic lupus...
Paget disease, Bowen and malignant melanoma in situ are intraepidermal neoplasms, characterized by the presence of pagetoid scatter atypical cells epidermis. This study reviewed frequency select histologic criteria to validate their usefulness distinction between these entities.One hundred forty-four specimens with diagnosis 144 disease (mammary extramammary), were examined microscopically define frequencies present each disease.Comparison mammary extramammary showed no significant...
Cutaneous metastases are unusual presenting symptoms of lung cancer. Therefore, they prone to be misdiagnosed and missed. The report describes a case forty-nine-year-old female with painful zosteriform rashes showing multiple vesicle-like papules localized on the left breast for 10 days. patient had been diagnosed as adenocarcinoma at department oncology one year ago. Skin biopsy revealed blue nodular lesions in dermis, composed clustered heterogeneous tumor cells glandular formation....
Precancerous high-grade squamous intraepithelial lesion (HSIL), the current consensus terminology for anogenital cell carcinoma in situ (SCCIS), often presents with distinctive histopathologic findings that may be a function of anatomic site or associated human papillomavirus infection.Fifty-six specimens HSIL were compared an equal number SCCIS from non-anogenital sites regard to presence parakeratosis, flag sign stratum corneum, compact hypergranulosis, koilocytes, small blue cells, clonal...
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Abstract Background Micronized acellular dermal matrix (mADM) can induce tissue regeneration and repair, filling. Objectives The efficacy safety of were evaluated in the treatment atrophic acne scar. Methods In this single‐blinded, self‐controlled, split‐face study, 16 patients (48 scar sites) divided into group (24 control sites). One side affected area was treated with mADM combined platelet rich plasma (PRP) injection as group; other PRP group. by Acne assessment scale (ASAS) Scar Weight...
The authors investigated the expression of IgG4 and IgG in cutaneous Rosai-Dorfman Disease (CRDD) to further improve understanding this disease.The retrospectively reviewed clinicopathological features 23 CRDD patients. diagnosed by presence emperipolesis immunohistochemical (IHC) staining histiocytes consisting S-100(+)/CD68(+)/CD1a(-) cells. expressions specimens were assessed IHC (EnVision) quantitatively calculated a medical image analysis system.All patients, including 14 males 9...