A5074560590- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- SARS-CoV-2 and COVID-19 Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac tumors and thrombi
- Viral gastroenteritis research and epidemiology
- Acute Ischemic Stroke Management
- Virology and Viral Diseases
- Respiratory viral infections research
- Coronary Interventions and Diagnostics
- Renal Diseases and Glomerulopathies
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Lipid metabolism and disorders
- Diabetic Foot Ulcer Assessment and Management
- Acute Kidney Injury Research
- Vasculitis and related conditions
- Paraoxonase enzyme and polymorphisms
- Intracerebral and Subarachnoid Hemorrhage Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Jinan Central Hospital
2023-2024
Shandong First Medical University
2023-2024
Shandong University
2023-2024
Sun Yat-sen University
2024
Peking Union Medical College Hospital
2012-2021
Beijing Center for Disease Prevention and Control
2019-2021
Guangdong Provincial People's Hospital
2020
Zhongda Hospital Southeast University
2020
First Affiliated Hospital of Jinan University
2016-2019
Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease in children may be fatal. A vaccine against EV71 needed.We conducted randomized, double-blind, placebo-controlled phase 3 trial involving healthy 6 to months age Guangxi Zhuang Autonomous Region, China. Two doses an inactivated or placebo were administered intramuscularly, with 4-week interval between doses, monitored for up 11 months. The primary end point was protection caused by EV71.A total 12,000 randomly assigned...
Objective To investigate the value of myosteatosis in predicting prognosis patients with ST-elevation myocardial infarction (STEMI). Methods This retrospective study involved 324 STEMI who had undergone emergency percutaneous coronary intervention (PCI) at our institution between 2017 and 2020. Myosteatosis was assessed using mean muscle attenuation (MMA). Cox proportional hazards models were utilized to identify prognostic determinants required for construction a nomogram. The...
SARS-CoV-2 caused the COVID-19 pandemic that lasted for more than a year. Globally, there is an urgent need to use safe and effective vaccines immunization achieve comprehensive protection against infection. Focusing on developing rapid vaccine platform with significant immunogenicity as well broad high efficiency, we designed spike protein receptor-binding domain (RBD) displayed self-assembled ferritin nanoparticles. In 293i cells eukaryotic expression system, this candidate was prepared...
To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy. A sub-cohort 1,100 volunteers from Guangxi Province in China was eligible for enrolment randomly administered either EV71 or a placebo days 0 28 phase III clinical trial then observed following 2 years with approval by independent ethics committee Zhuang Autonomous Region, China. Serum samples 350 participants who provided full series blood (at all sampling points)...
Plasma D-dimer has been used as a complementary initial diagnostic marker for acute aortic dissection (AAD). However, its prognostic role in patients with Stanford type A AAD not clarified. We prospectively enrolled consecutive series of suspect presented to our emergency department and measured the plasma level (Stago-evolution, France) immediately following admission. The diagnosis was confirmed by aorta angiography multidetector computed tomography each patient. Patients were divided into...
Previous studies have examined the shifts in traditional familial values among Chinese populations. It was argued that diminished or eroded due to Westernization and modernization. Instead of collectivist-individualist divide, this study aims understand role neoliberal discourse Hong Kong parents’ beliefs elder care. Using data from 120 in-depth individual interviews with parents different generations, found four themes: (1) notion self-reliance; (2) intertwinement ideas filial values; (3)...
We compared admission systolic blood pressure (SBP), diastolic (DBP), pulse (PP), and mean arterial (MAP) in predicting 30-day all-cause mortality patients with ST-segment elevation myocardial infarction (STEMI) without cardiogenic shock.A retrospective study was performed 7,033 consecutive STEMI patients. Multivariate-adjusted hazard ratios (HRs) a 10mm Hg increment quartiles of each were determined by Cox proportional analyses; Wald χ (2) tests used to compare the strength...
Objective: This study investigated the association between small vessel disease (SVD) burden, a combination of multiple SVD markers and cognitive dysfunction after stroke. Methods: The sample comprised 451 patients with first-ever acute ischemic Cognitive functions were assessed Mini-Mental State Examination (MMSE) at 3, 9, 15 months index impairment was defined as an MMSE score ≤26. A total score, indicating constructed by summing scores 4 (white matter hyperintensities [WMHs], lacunes,...
Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, patients might still suffer from poor outcomes caused by no-reflow and ischemic/reperfusion injury. Tongxinluo (TXL), traditional Chinese medicine, has been preliminarily demonstrated to reduce We further hypothesize that TXL treatment is also effective in reducing clinical end points for the with STEMI. The CTS-AMI trial prospective, randomized,...
Background: Mumps, a communicable, acute and previously well-controlled disease, has had recent occasional resurgences in some areas.Methods: A randomized, double-blind, controlled multistep phase I study of an F-genotype attenuated mumps vaccine produced human diploid cells was conducted. total 300 subjects were enrolled divided into 4 age groups: 16–60 years, 5–16 2–5 years 8–24 months. The groups immunized with one injection per subject. Three different doses the vaccine, (3.5 ± 0.25...
Background Chronic kidney disease (CKD) is a growing public health problem with well-established risk factors. Other contributing factors, however, remain to be identified. Systemic inflammation in asthma plays significant role the development of other diseases. We therefore initiated study assess whether prevalence associated an increase CKD. Methods conducted retrospective cohort using data from 3015 patients aged 14 years and older who were registered followed up Asthma Control Study at...
Studies have shown that diabetes mellitus (DM) is a risk factor for cardiovascular disease, including atrial fibrillation (AF); however, the clinical characteristics and prognostic impact of DM in patients with nonvalvular AF not been well understood China.Included were 1644 consecutive AF. Endpoints included all-cause mortality, stroke, major bleeding, combined endpoint events (CEE) during 1-year follow-up.The prevalence was 16.8% patients. Compared non-diabetic patients, diabetic older...