A5067981602- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Healthcare Systems and Public Health
- Obstructive Sleep Apnea Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Heart rate and cardiovascular health
- Cardiac electrophysiology and arrhythmias
- Ubiquitin and proteasome pathways
- Acute Ischemic Stroke Management
- Infective Endocarditis Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Biomarkers in Disease Prognosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
China Association for Science and Technology
2023
Peking Union Medical College Hospital
2013-2023
Fu Wai Hospital
2014-2021
State Key Laboratory of Cardiovascular Disease
2014-2016
China Academy of Chinese Medical Sciences
2012
Abstract Background Stress hyperglycemia is a strong predictor of adverse outcomes in patients with acute myocardial infarction (AMI). Recently, the stress ratio (SHR) has been designed as an index to identify true risk; however, data regarding impact SHR on prognosis ST-segment elevation (STEMI) remains limited. This study aimed evaluate predictive value STEMI and assess whether it can improve efficiency Thrombolysis Myocardial Infarction (TIMI) risk score. Methods included 7476 consecutive...
Purpose: The management of the coexistence chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) remains unclear due to a lack evidence. This study aimed find effect beta-blockers renin-angiotensin-aldosterone system inhibitors (RAASi) in this special population. Patients Methods: We designed an observational real-world that included 2016 AF patients from 20 hospitals across country. diagnosis COPD was extracted case report forms confirmed by specialists. endpoint...
Background The association between DNA methylation age acceleration (DNAmAA) and cardiovascular‐kidney‐metabolic (CKM) syndrome stages long‐term mortality in the population with CKM remains unclear. Methods Results This cohort study included 1889 participants from National Health Nutrition Examination Survey (1999–2002) data. DNAmAA was calculated as residuals regression of on chronological age. primary outcome all‐cause mortality, cardiovascular noncardiovascular secondary outcomes....
We performed a retrospective analysis involving 1269 patients with atrial fibrillation (AF) to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) on long-term outcomes. The primary outcomes were all-cause mortality and combined end point events (CEEs). Cox proportional hazards regression net reclassification improvement (NRI) performed. During median follow-up 3.32 years, 285 deaths 376 CEEs occurred. With elevation NLR, incidence (2.77, 4.14, 6.12, 12.18/100 person-years)...
Abstract Background Renin–angiotensin–aldosterone-system inhibitors markedly play an active role in the primary prevention of atrial fibrillation (AF), but impact angiotensin-converting enzyme (ACEIs) or angiotensin receptor blockers (ARBs) on mortality patients with AF remains unclear. This study aimed to examine relationship between treatment ACEIs ARBs and emergency department (ED) hypertension. Methods multicenter enrolled 2016 ED from September 2008 April 2011; 1110 hypertension were...
We aimed to explore the impact of adherence Life's Simple 7 (LS7) metrics on risk obstructive sleep apnea (OSA), and inflammation association, in adults United States. Data from 13,825 community-dwelling aged ≥ 20 years recruited National Health Nutrition Examination Surveys (NHANES) 2005–2008, 2015–2018 was analyzed. The LS7 score calculated based AHA definition metrics. diagnosis OSA self-reported symptoms disturbance using a standard questionnaire. Multivariable Apnea Prediction (MAP)...
Dabigatran and rivaroxaban may simultaneously inhibit coagulation platelet activation. This study aimed to reveal the in-vitro effects of dabigatran on thrombin generation aggregation (PAg) derived via tissue factor (TF) pathway. Citrated blood was obtained from six healthy adults (26-60 years old) pretreated with increasing concentrations or rivaroxaban. Plasmatic endogenous potential (ETP) measured by calibrated automated thrombogram method. The whole PAg evaluated a kinetic counting TF...
To explore the impact of age on association between body mass index (BMI) and all-cause mortality in patients with atrial fibrillation (AF). A total 1991 AF (69 ± 13 years, 54.9% female) were divided into three groups: < 65 65-75 > 75 followed for one year. The primary outcome was defined as mortality, secondary outcomes including thromboembolism major bleeding. Cox regression models utilized to estimate hazard ratios (HRs) 95% confidence intervals (CIs). Compared aged elder groups had much...
The ideal blood pressure (BP) target for patients with atrial fibrillation (AF) is still unclear. present study aimed to assess the effect of baseline BP on all-cause mortality in AF.This registry included 20 emergency centers across China and consecutively enrolled AF from 2008 2011. All participants were followed 1 year ± month. primary endpoint was mortality.During follow-up, 276 (13.9%) deaths occurred. Kaplan-Meier curves showed that a systolic (SBP) ≤110 mmHg or >160 associated higher...
Acute myocarditis mimicking ST-segment elevation myocardial infarction (STEMI) is highly deceptive for an accurate diagnosis, and a systematic study lacking with regard to the clinical features prognosis of this distinct entity. Patients suspected STEMI eventually diagnosed by cardiac magnetic resonance (CMR) from January 2012 April 2016 at Fuwai Hospital were identified reviewing medical records electronic databases. Follow-up was conducted visits phone contacts in median duration 17...
Studies have shown that diabetes mellitus (DM) is a risk factor for cardiovascular disease, including atrial fibrillation (AF); however, the clinical characteristics and prognostic impact of DM in patients with nonvalvular AF not been well understood China.Included were 1644 consecutive AF. Endpoints included all-cause mortality, stroke, major bleeding, combined endpoint events (CEE) during 1-year follow-up.The prevalence was 16.8% patients. Compared non-diabetic patients, diabetic older...
There have been several studies of atrial fibrillation (AF) over the past decades; however, data from Chinese patients are scarce. The aim study was therefore to describe patient characteristics, risk profile and management strategies for AF presenting emergency department (ED).We conducted a prospective, multicentre registry with or flutter (AFL) in China. Participants were enrolled at 20 EDs, then regarding baseline characteristics treatment EDs collected.Of 2016 patients, 1104 (54.8%)...
Recent studies have demonstrated that ivabradine (IVA), is a selective inhibitor of funny current (If) and exerts antiarrhythmic effects in the settings various diseases such as heart failure myocardial ischemia. However, little known regarding long-term IVA treatment on If hyperpolarization-activated cyclic nucleotide gated (HCN) channel overexpression.We investigated both HCN expression wild-type (WT) mice transgenic (TG) atrial fibrillation (AF) (heart-specific overexpressing (pro) renin...
There is lack of data about patient characteristics, practice patterns, and long-term adverse outcomes in patients with atrial fibrillation (AF) attending emergency departments (EDs) China. A total 2016 from 20 representative EDs were included. During 1 year, all-cause mortality was 291 (14.6%) cases, stroke/noncentral nervous system systemic embolism rate 159 (8.0%) major bleeding 26 (1.3%) cases. Heart failure, the cause mortality, accounted for 43.0% deaths. Of 375 (18.6%) who used...