A5017364136- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Genetic Associations and Epidemiology
- Pulmonary Hypertension Research and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Acute Ischemic Stroke Management
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Blood Coagulation and Thrombosis Mechanisms
- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- COVID-19 Impact on Reproduction
- Adipokines, Inflammation, and Metabolic Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Peking Union Medical College Hospital
2018-2024
Fu Wai Hospital
2018-2023
E Ink (South Korea)
2022
Shanghai Pulmonary Hospital
2022
State Key Laboratory of Cardiovascular Disease
2018-2020
Shandong University
2018
National Yang Ming Chiao Tung University
2010
A growing number of cohort studies revealed an inverse association between cheese intake and cardiovascular diseases, yet the causal relationship is unclear.To assess intake, diseases biomarkers.A two-sample Mendelian randomization (MR) analysis based on publicly available genome-wide was employed to infer relationship. The effect estimates were calculated using random-effects inverse-variance-weighted method.Cheese per standard deviation increase causally reduced risks type 2 diabetes (odds...
Background: Previous observational studies provided conflicting results on the association between low-density lipoprotein cholesterol (LDL-C) level and risk of Alzheimer's disease (AD). Objective: We used two-sample Mendelian randomization (MR) study to explore causal associations LDL-C risks individual, paternal, maternal, family history AD. Methods: Summary-level genetic data for were acquired from UK Biobank GWAS. Corresponding AD obtained NHGRI-EBI Catalog human genome-wide studies....
Background In patients with acute coronary syndrome (ACS) or undergoing percutaneous intervention (PCI), female have a worse short-term prognosis than male has been consistently concluded in many studies. However, the impact of sex differences on long-term remains uncertain. Additionally, women are underrepresented clinical trials exploring optimal antithrombotic strategies atrial fibrillation (AF) and ACS PCI. To bridge this gap, study aimed to investigate characteristics, treatment, outcomes AF
Purpose: The management of the coexistence chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) remains unclear due to a lack evidence. This study aimed find effect beta-blockers renin-angiotensin-aldosterone system inhibitors (RAASi) in this special population. Patients Methods: We designed an observational real-world that included 2016 AF patients from 20 hospitals across country. diagnosis COPD was extracted case report forms confirmed by specialists. endpoint...
Background: The outbreak of 2019 coronavirus disease (COVID-19) has become a global pandemic. Although it long been suspected that COVID-19 could contribute to the development mental illness, and individuals with pre-existing illness may have higher risk poorer outcomes from infection, no evidence established causal association between them thus far. Methods: To investigate associations in support severity illnesses, we leveraged large-scale genetic summary data genome-wide study (GWAS)...
Aims: This study was aimed to apply a Mendelian randomization design explore the causal association between coronavirus disease 2019 (COVID-19) and three cardio-cerebrovascular diseases, including atrial fibrillation, ischemic stroke, coronary artery disease. Methods: Two-sample used determine following: 1) effect of COVID-19 on fibrillation (55,114 case participants vs 482,295 control participants), (34,541 261,984 stroke (34,217 40,611 which were obtained from European Bioinformatics...
Background Diabetes was considered as a risk factor for venous thromboembolism (VTE), but conflicting findings have been reported from observational studies. This study aimed at investigating the causal associations of type 1 and 2 diabetes with VTE, including deep vein thrombosis (DVT) pulmonary embolism (PE). Methods We designed bidirectional two-sample Mendelian randomization (MR) analysis by using summary-level data large genome-wide association studies performed in European individuals....
Previous observational studies have reported potential associations among attention-deficit/hyperactivity disorder (ADHD), obesity, and diabetes (including type 1 2 mellitus [T1DM/T2DM]). However, whether the association between ADHD is mediated by obesity unknown.With two-sample Mendelian randomization, we analysed causal effect of on T1DM T2DM six obesity-related traits [including body mass index, waist circumference (WC), hip circumference, waist-to-hip ratio (WHR), fat percentage basal...
Obesity, especially abdominal obesity, is an independent indicator of increased cardiovascular risk. Observational studies have shown observational association between obesity and venous thromboembolism (VTE). As a type VTE, pulmonary embolism (PE) also associated with obesity. However, it unclear whether the observed associations are causal or caused by confounding bias reverse causality. We performed two-sample test obtaining exposure dataset waist circumference (WC) hip (HC) from Neale...
This study aimed to evaluate the causal association between obesity and hypertension disorders in pregnancy.Two-sample Mendelian randomization (MR) was conducted based on data obtained from GIANT (n = 98,697 participants) consortium FinnGen 96,449 determine effect of risk pregnancy. Based a genome-wide significance, 14 single-nucleotide polymorphisms (SNPs) associated with obesity-related databases were used as instrumental variables. The random-effects inverse-variance weighted (IVW) method...
This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined influence DM traits (including insulin resistance, glycated hemoglobin, fasting glucose) on risk PAH. Moreover, examined effects SGLT2 Genetic proxies for were identified as variants SLC5A2 gene that associated with both...
Abstract Background Patients with pulmonary arterial hypertension (PAH) exhibit a distinct gut microbiota profile; however, the causal association between microbiota, associated metabolites, and PAH remains elusive. We aimed to investigate this explore whether dietary patterns play role in its regulation. Methods Summary statistics of diet, were obtained from genome-wide studies. The inverse variance weighted method was primarily used measure effect, sensitivity analyses using median, mode,...
The prevalence and distribution of congenital thrombophilia is still unclear in patients with pulmonary embolism (PE). We aimed to determine the clinical characteristics PE their subsequent outcomes. A prospective observational study was conducted from May 2013 June 2018. total 436 consecutive were enrolled. All tested for protein C, S, antithrombin III (ATIII), factor V Leiden, prothrombin G20210A mutations. median follow-up duration ∼800 days (range, 11-1872 days). Congenital diagnosed 31...
Observational studies have reported that levels of vitamin D were associated with the incidence chronic obstructive pulmonary disease (COPD), but relationship between them may been confounded in previous studies. In this study, we aimed to determine 25-hydroxyvitamin (25OHD) and risk COPD by two-sample Mendelian randomization (MR) analysis. Summary statistics for 25OHD study obtained from EBI (n = 496,946) consortium Finn 187,754) consortium. MR was adopted explore effect genetically...
Several observational studies indicated that atrial fibrillation might aggravate other cardiovascular diseases apart from ischaemic stroke. However, it remains to be determined whether these associations reveal independent causation. Using Mendelian randomization (MR), we systematically investigated how genetically predicted affected and cardiac death.Summary-level data for were obtained public genome-wide association study data. The random inverse-variance weighted method was treated as the...
The causalities between the coronavirus disease 2019 (COVID-19) and risk of rheumatic diseases remain unclear. purpose this study was to investigate causal effect COVID-19 on occurrence.Single nucleotide polymorphisms (SNPs), acquired from published genome-wide association studies, were used perform 2-sample Mendelian randomization (MR) cases diagnosed with (n = 13 464), 444 199), juvenile idiopathic arthritis (JIA, n 15 872), gout 69 374), systemic lupus erythematosus (SLE, 3094),...
Abstract Introduction: Observational studies have revealed an association between waist circumference (WC) and atrial fibrillation (AF). However, it is difficult to infer a causal relationship from observational because the observed associations could be confounded by unknown risk factors. Therefore, role of WC in AF unclear. This study was designed investigate using two-sample Mendelian randomization (MR) analysis. Methods: In our MR analysis, genetic variation used as instrumental variable...
Abstract Hepatotoxicity with low‐molecular‐weight heparin (LMWH) or fondaparinux is a relatively common adverse reaction. This study assessed the effects of LMWH and on liver function in patients pulmonary embolism based retrospective cohort. As result, total 463 treated (enoxaparin sodium nadroparin calcium) were included. Liver dysfunction was identified 79 (17.1%), whom 97.5% had grade 1 drug‐induced injury (DILI) 2.5% 2 DILI. The results showed that usually occurred first week after...