A5074632929- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Vascular Anomalies and Treatments
- Cardiovascular Issues in Pregnancy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Liver Disease and Transplantation
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Glycosylation and Glycoproteins Research
- Health Systems, Economic Evaluations, Quality of Life
- PI3K/AKT/mTOR signaling in cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Galectins and Cancer Biology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adenosine and Purinergic Signaling
- Circular RNAs in diseases
- Nitric Oxide and Endothelin Effects
- Sepsis Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
Guangdong Provincial People's Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Southern Medical University
2024
Peking Union Medical College Hospital
2017-2024
Guangdong Academy of Medical Sciences
2024
Cincinnati Children's Hospital Medical Center
2023
Fu Wai Hospital
2017-2019
Molina Center for Energy and the Environment
2018
Background Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease with high heritability. Although several predisposing genes have been linked to IPAH, the genetic aetiology remains unknown for large number of IPAH cases. Methods We conducted an exome-wide gene-based burden analysis on two independent case–control studies, including total 331 cases and 10 508 controls. Functional assessments were analyse effects mutations protein biosynthesis function. Results The gene encoding...
Background Differences in the clinical outcomes and level of risk among Asian versus non-Asian patients with atrial fibrillation (AF) have been sparsely investigated. Objective To provide a contemporary prospective comparison for newly diagnosed AF, between regions. Methods Six countries (China, Japan, India, Singapore, South Korea Thailand) 29 outside Asia participated Global Anticoagulant Registry FIELD-AF (GARFIELD-AF) study. Newly enrolled 2010 2016, were followed up for≥2 years. The...
Pathological mechanisms of pulmonary arterial hypertension (PAH) remain largely unexplored. Effective treatment PAH remains a challenge. The aim this study was to discover the underlying mechanism through functional metabolomics and help develop new strategies for prevention PAH.Metabolomic profiling plasma in patients with idiopathic evaluated high-performance liquid chromatography mass spectrometry, spermine identified be most significant validated another independent cohort. roles...
DNA methylation plays critical roles in vascular pathology of pulmonary hypertension (PH). The underlying mechanism, however, remains undetermined. Here, we demonstrate that global was elevated the lungs PH rat models after monocrotaline administration or hypobaric hypoxia exposure. We showed methyltransferase 3B (DNMT3B) up-regulated both patients and rodent models. Furthermore, Dnmt3b-/- rats exhibited more severe remodeling. Consistently, inhibition DNMT3B promoted proliferation/migration...
BACKGROUND: The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is multifactorial and growing evidence has indicated that hematological disorders are involved. Clonal hematopoiesis indeterminate potential (CHIP) recently been associated with an increased risk both malignancies cardiovascular diseases. However, the prevalence clinical relevance CHIP in patients CTEPH remains unclear. METHODS: Using stepwise calling on next-generation sequencing data from 499 referred to...
The pathological mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood, and inflammation has been reported to be one its etiological factors. IgG regulates systemic inflammatory homeostasis, primarily through N-glycans. Little known about N-glycosylation in CTEPH. We aimed map the N-glycome CTEPH provide new insights into pathogenesis discover novel markers therapies.We characterized plasma patients with a discovery cohort validated our results an...
Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking reprogramming in experimental models. We aim to evaluate the changes and provide new insight into endogenous disorders of PAH. A single subcutaneous injection monocrotaline (MCT) (60 mg kg− 1) was used for rats establish model. Hemodynamics right ventricular hypertrophy were adopted...
The prevalence and distribution of congenital thrombophilia is still unclear in patients with pulmonary embolism (PE). We aimed to determine the clinical characteristics PE their subsequent outcomes. A prospective observational study was conducted from May 2013 June 2018. total 436 consecutive were enrolled. All tested for protein C, S, antithrombin III (ATIII), factor V Leiden, prothrombin G20210A mutations. median follow-up duration ∼800 days (range, 11-1872 days). Congenital diagnosed 31...
The role of congenital thrombophilia in chronic thromboembolic pulmonary hypertension (CTEPH) remains unresolved.The purpose this study was to investigate the prevalence, genetic background, and clinical phenotype CTEPH.In total, 367 patients with CTEPH from May 2013 December 2020 were consecutively enrolled cross-sectional FuWai Hospital Peking Union Medical College China. primary outcome occurrence diagnosed through tests for anticoagulants activity (including protein C, S, antithrombin...
Background: Right ventricle (RV) function is among the most important prognostic factors for pulmonary arterial hypertension (PAH) patients. Inhaled iloprost, an inhaled member of prostacyclin family, effective treatment severe PAH and acute RV failure. However, effects iloprost on physiology have not been thoroughly explored in past. Materials Methods: This prospective study involved 69 incident patients, including 23 idiopathic (IPAH) 26 patients with associated connective tissue disease...
Sanger sequencing, the traditional "gold standard" for mutation detection, has been wildly used in genetic testing of pulmonary artery hypertension (PAH). However, with advent whole-exome sequencing (WES), few studies have compared accuracy WES and routine PAH. PAH individuals were enrolled from Fu Wai Hospital Shanghai Pulmonary Hospital. was to analyze DNA samples 120 patients whose bone morphogenetic protein receptor type 2 (BMPR2) statuses had previously studied using sequencing. The...
Pulmonary arterial hypertension (PAH) is a rare but severe illness associated with mutations in the PTGIS gene. The single nucleotide variants may lead to impairment of endothelial cells functions, resulting proliferation smooth muscle and occlusion pulmonary arterioles. We derived an induced pluripotent cell line from PAH patient heterozygous c.755 G > A, which could serve as unique model understand pathogenesis PAH.
The potential impact of pre-existing coronary artery stenosis (CAS) on acute pulmonary embolism (PE) episodes remains underexplored. This study aimed to investigate the association between CAS and elevation high-sensitivity cardiac troponin I (hs-cTnI) levels in patients with PE.
Background: The pathological mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood and inflammation was reported to be one its etiological factors. Immunoglobulin G (IgG) regulates systemic inflammatory homeostasis by alternative N-glycans primarily. Currently, little known regarding IgG N-glycosylation in CTEPH. We aimed map the N-glycome CTEPH provide a more thorough understanding pathogenesis potentially discover novel biomarkers therapies. Methods:...
Our previous study found that mutations in the PTGIS gene contributed high susceptibility to pulmonary arterial hypertension (PAH). We have generated disease-specific induced pluripotent stem cell (iPSC) lines from a PAH patient carrying heterozygous c.1339 G > A mutation gene. The iPSC can be differentiated into endothelial cells investigate pathogenesis of associated with gene, which could provide valuable resources for personalized medicine.