A5008489644- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- Vascular Anomalies and Treatments
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Insects and Parasite Interactions
- Advanced Breast Cancer Therapies
- Gout, Hyperuricemia, Uric Acid
- Dental Anxiety and Anesthesia Techniques
- Insect Utilization and Effects
- Neurogenesis and neuroplasticity mechanisms
First Affiliated Hospital Zhejiang University
2025
Peking Union Medical College Hospital
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Guangdong Academy of Medical Sciences
2024
Shanghai Skin Disease Hospital
2022-2023
Tongji University
2022-2023
Ningbo University
2022
Fu Wai Hospital
2018-2019
Shanghai Stomatological Hospital
2018
Guang’anmen Hospital
2011
Pathological mechanisms of pulmonary arterial hypertension (PAH) remain largely unexplored. Effective treatment PAH remains a challenge. The aim this study was to discover the underlying mechanism through functional metabolomics and help develop new strategies for prevention PAH.Metabolomic profiling plasma in patients with idiopathic evaluated high-performance liquid chromatography mass spectrometry, spermine identified be most significant validated another independent cohort. roles...
BACKGROUND: The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is multifactorial and growing evidence has indicated that hematological disorders are involved. Clonal hematopoiesis indeterminate potential (CHIP) recently been associated with an increased risk both malignancies cardiovascular diseases. However, the prevalence clinical relevance CHIP in patients CTEPH remains unclear. METHODS: Using stepwise calling on next-generation sequencing data from 499 referred to...
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive pulmonary artery (PA) remodeling. T helper 2 cell (Th2) immune response involved in PA remodeling during PAH progression. Here, we found that CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cell) expression was up-regulated circulating CD3+CD4+ cells patients with idiopathic and rodent models. disruption dramatically ameliorated different mouse deficiency suppressed...
The aim of this study was to develop and validate a nomogram predicting progression-free survival (PFS) for adult patients with positive acute lymphoblastic leukemia(Ph + ALL) who have undergone allogeneic hematopoietic stem cell transplantation(allo-HSCT) tyrosine kinase inhibitor(TKI) treatment. Data were retrospectively collected from 176 diagnosed Ph ALL treated allo-HSCT TKIs at First Affiliated Hospital, Zhejiang University School Medicine, between January 2015 May 2023. 70% the...
This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu's arteritis-associated pulmonary hypertension (TA-PH).We conducted a nationally representative cohort of TA-PH using data from National Rare Diseases Registry System China. Patients artery involvement who fulfilled diagnostic criteria arteritis were included. The primary was time diagnosis occurrence all-cause death. Between January 2007 2019, total 140 included, mean age 41.4...
The pathological mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood, and inflammation has been reported to be one its etiological factors. IgG regulates systemic inflammatory homeostasis, primarily through N-glycans. Little known about N-glycosylation in CTEPH. We aimed map the N-glycome CTEPH provide new insights into pathogenesis discover novel markers therapies.We characterized plasma patients with a discovery cohort validated our results an...
Hand, foot and mouth disease (HFMD) is a rising public health problem has attracted considerable attention worldwide. The purpose of this study was to develop an optimal model with meteorological factors predict the epidemic HFMD.Two types methods, back propagation neural networks (BP) auto-regressive integrated moving average (ARIMA), were employed forecasting models, based on monthly HFMD incidences during 2009-2016 in Jiangsu province, China. Root mean square error (RMSE) absolute...
Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilia with uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess association APS clinical phenotype CTEPH. retrospectively reviewed data CTEPH patients referred our center. Clinical, angiographic, and hemodynamic were available for all patients. was diagnosed presence one or more positive antiphospholipid (aPL) tests confirmed than 12 weeks apart. Data compared between...
Lethal intestinal tissue toxicity is a common side effect and dose-limiting factor in chemoradiotherapy. Chemoradiotherapy can trigger DNA damage induce P53-dependent apoptosis LGR5+ stem cells (ISCs). Gamma-aminobutyric acid (GABA) its A receptors (GABAAR) are present the gastrointestinal tract. However, functioning of GABAergic system ISCs poorly defined. We found that GABAAR α1 (GABRA1) levels increased murine intestine after GABRA1 depletion protected from chemoradiotherapy-induced...
The role of congenital thrombophilia in chronic thromboembolic pulmonary hypertension (CTEPH) remains unresolved.The purpose this study was to investigate the prevalence, genetic background, and clinical phenotype CTEPH.In total, 367 patients with CTEPH from May 2013 December 2020 were consecutively enrolled cross-sectional FuWai Hospital Peking Union Medical College China. primary outcome occurrence diagnosed through tests for anticoagulants activity (including protein C, S, antithrombin...
Yangyinqingfei Decoction (YYQFD), a traditional Chinese prescription, is well known in the treatment of diphtheria and lung-related diseases clinic. However, whether it can be used to block lung injury caused by air pollutant remains unclear. In present study, effect YYQFD was addressed using PM2.5-induced mice model. It shown that significantly improved pulmonary functions exposed PM2.5, levels IL-6, TNF-α MDA were decreased while SOD increased serum bronchoalveolar fluid. The potential...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Fractional Flow Reserve (FFR) is regarded as a fundamental index to assess pulmonary artery stenosis. The application of FFR can increase the accuracy detection However, invasive examination may carry number physiological risks for patients. Therefore, we propose personalized circulation model non-invasively calculate xmlns:xlink="http://www.w3.org/1999/xlink">Methodology:</i> We...
BACKGROUND Sepsis causes the highest mortality in non-cardiovascular intensive care units worldwide. Recent research has demonstrated that late phase of sepsis, characterized as septic immunosuppression, is central pathophysiological mechanism immune dysfunction. Investigating suppressive cells may identify possible targets for therapy. MATERIAL AND METHODS We used LPS 2-hit model dendritic (DCs) to establish endotoxin tolerance, and co-cultured with splenocytes. Co-culture responses gene...
The color difference in human subcutaneous fat (SF) and orbital (OF) is apparent, but the reasons have been rarely elaborated. We speculate that differences carotenoid lipid contents may account for discrepancy color. In this study, intrinsic SF OF were analyzed using ultrahigh-performance liquid chromatography coupled with Q-Exactive mass spectrometry/mass spectrometry (UPLC-QE Plus LC-MS/MS). Lipid profiling was performed an independent batch. morphology between septum differed...
Background: The association between anticoagulation outcomes and prior history of venous thromboembolism (VTE) in chronic thromboembolic pulmonary hypertension (CTEPH) has not been established. This study aimed to compare the efficacy safety treatment CTEPH patients with without VTE. Methods: A total 333 prescribed anticoagulants were retrospectively included from May 2013 April 2019. clinical characteristics collected at their first admission. Incidental recurrent VTE clinically relevant...
While sex differences characterize susceptibility and severity of idiopathic pulmonary arterial hypertension (IPAH), our understanding the relationship between levels gonadotropins hormones in fertile women disease is limited. We aimed to investigate whether gonadotropin hormone reproductive age were associated with risk mortality IPAH.We did a matched case-control study. Cases female patients admitted Shanghai Pulmonary Hospital (Tongji University School Medicine, Shanghai, China) during...
Simultaneous multiple primary lung cancer has been detected increasingly nowadays with the development of image technology. However, clinicopathologic characteristics and outcomes are not clear.All consecutive patients diagnosed as simultaneous according to Martini-Melamed American College Chest Physicians criteria from June 2010 2019 in our center were enrolled. The compared between same histological type different types.A total 336 enrolled, consisting 297 (88.4%) 39 (11.6%) types....
患儿，男，13岁，因“反复发热、咳嗽、间断皮肤淤点10年”入院。主要临床特点为反复呼吸道感染和间断血小板降低。既往史及个人生长发育史正常，父母非近亲婚配。基因检测示CD3G基因复合杂合变异，父源c.213delA，p.K71Nfs*40及母源c.360delT，p.F120Lfs*60，均评级为致病性变异。结合临床表现和基因检测结果诊断为CD3γ缺陷。给予激素治疗以及定期人免疫球蛋白输注支持治疗后病情控制良好。.