A5102015133- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Hematopoietic Stem Cell Transplantation
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Chemokine receptors and signaling
- Parallel Computing and Optimization Techniques
- T-cell and Retrovirus Studies
- COVID-19 Clinical Research Studies
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Nerve Disorders
- Cerebral Palsy and Movement Disorders
First Affiliated Hospital Zhejiang University
2013-2025
Zhejiang University
2013-2024
Yangzhou University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2019-2024
Indiana University
2021-2024
Cell Technology (China)
2024
Shandong University of Technology
2024
Beijing University of Chinese Medicine
2023
Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate causes, risk factors, and outcomes AKI in COVID-19 We found that angiotensin-converting enzyme II (ACE2) transmembrane protease serine 2 (TMPRSS2) were mainly expressed by different cell types human kidney. However, autopsy samples, severe acute respiratory syndrome (SARS-CoV-2) nucleoprotein was detected ACE2 + or TMPRSS2 renal...
Abstract Tremendous efforts have been made to improve diagnosis and treatment of COVID-19, but knowledge on long-term complications is limited. In particular, a large portion survivors has respiratory complications, currently, experienced radiologists state-of-the-art artificial intelligence systems are not able detect many abnormalities from follow-up computerized tomography (CT) scans COVID-19 survivors. Here we propose Deep-LungParenchyma-Enhancing (DLPE), computer-aided detection (CAD)...
The aim of this study was to develop and validate a nomogram predicting progression-free survival (PFS) for adult patients with positive acute lymphoblastic leukemia(Ph + ALL) who have undergone allogeneic hematopoietic stem cell transplantation(allo-HSCT) tyrosine kinase inhibitor(TKI) treatment. Data were retrospectively collected from 176 diagnosed Ph ALL treated allo-HSCT TKIs at First Affiliated Hospital, Zhejiang University School Medicine, between January 2015 May 2023. 70% the...
<sec> <title>BACKGROUND</title> Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of advanced esophageal squamous cell carcinoma (ESCC). However, response varies. </sec> <title>OBJECTIVE</title> This study investigates prognostic value dynamic lactate dehydrogenase (LDH) changes during ICI therapy in predicting outcomes. <title>METHODS</title> We retrospectively analyzed clinical data from 126 patients with ESCC treated first-line ICIs. Serum LDH levels were...
Camalexin is a phytoalexin that accumulates in various cruciferous plants upon exposure to environmental stress and plant pathogens. It was shown camalexin has potent antitumor properties, but its underlying mechanisms are still elusive. In the present study, we evaluated effects of on human leukemic cells normal polymorph nuclear cells. CCK‐8 assay used determine cell viability after treatment. Apoptosis, intracellular reactive oxygen species (ROS) levels, loss mitochondrial membrane...
KMT2A rearrangement ( KMT2A-r) in patients with acute myeloid leukemia (AML) is associated poor outcomes; the prognostic factors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unclear. We investigated 364 adults AML who underwent allo-HSCT between April 2016 and May 2022, 45 had KMT2A-r among them. Propensity score analysis 1:1 matching nearest neighbor method identified 42 non– cohorts, respectively. The 2-year overall survival (OS), relapse-free (RFS),...
Artificial Intelligence (AI) is rapidly becoming a key driver of modern economic development, with its impact spanning multiple facets both microeconomic and macroeconomic levels. At the level, AI significantly alters consumer behavior business operations by enhancing individual decision-making efficiency optimizing internal corporate management. Simultaneously, as General Purpose Technology (GPT), fosters productivity improvements, industrial structure transformations, emergence new growth...
With the rapid development of Artificial Intelligence (AI) technology, global economic models and market structures are undergoing profound transformations, particularly in fields international trade logistics, where application AI is becoming a key driver for improving efficiency, reducing costs, enhancing customer experience. Traditional logistics systems face multiple challenges such as supply chain opacity, high transportation information asymmetry, low operational efficiency. The...
Multi-core processors are widely used in computer systems. As the performance of microprocessors greatly exceeds that memory, memory wall becomes a limiting factor. It is important to understand how large disparity speed between processor and influences scalability Java applications on emerging multi-core platforms. In this paper, we studied two popular benchmarks, SPECjbb2005 SPECjvm2008, platforms including Intel Clovertown AMD Phenom. We focus "partially scalable" benchmark programs. With...
Abstract BACKGROUND: Mantle cell lymphoma (MCL) is an incurable B‐cell malignancy, and patients with this disease have the poorest prognosis among all lymphomas. The signaling pathways that trigger MCL escape from immune surveillance are unclear. Because Toll‐like receptors (TLRs) initiate innate adaptive responses against invading pathogens, authors investigated impact of TLR in cells. METHODS: expression was examined lines primary tumors. examination focused on TLR4 its ligand...
With the development of novel therapeutic agents, survival multiple myeloma (MM) patients has much improved. However, disease is incurable due to drug resistance. Previous studies have found that high-mobility group box 1 (HMGB1) involved in inflammation, angiogenesis, DNA damage repair, and cancer invasion, progression, metastasis resistance high HMGB1 expression associated with poor MM prognosis, yet role mechanism remains unclear. Through gene Oncomine database analyses, we a prognosis...
Multi-core processors are widely used in computer systems. As the performance of microprocessors greatly exceeds that memory, memory wall becomes a limiting factor. It is important to understand how large disparity speed between processor and influences scalability Java applications on emerging multi-core platforms.
Extramedullary (EM) lesions are common in multiple myeloma (MM) and often related to the poor prognosis of MM but scarcely understood.In this retrospective study, baseline characteristics 357 newly diagnosed patients with extramedullary (EMM) their impact on were analyzed. All received first-line treatment bortezomib-based regimen.The overall incidence rate EM was 22.4%, detection PET/CT significantly higher than other imaging methods (P = 0.015). The cohorts consisted 10 cases extraosseous...
Histone deacetylases are promising therapeutic targets in hematological malignancies. In the work herein, we investigated effect of chidamide, a new subtype-selective histone deacetylase inhibitor that was independently produced China, on multiple myeloma and its associated bone diseases using different models. The cytotoxicity chidamide toward is due to induction cell apoptosis cycle arrest by increasing levels caspase family proteins p21 p27, among others. Furthermore, exhibited...
As countries underwent the initiation, peak, post-peak, and early vaccination stages of COVID-19, changing risk perception, coping behaviors corresponding psychological stress experienced by public over time was rarely reported. We conducted a national scale panel study using social-psychological data collected from 5,983 questionnaires to investigate interactions between anxiety level, perception behavior during different COVID-19 in China. found that sustained perceiving worries being...
SWe explored the incidence of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections in 131 patients with multiple myeloma (MM), 53 whom received daratumumab (Dara) treatments. The Dara group had more RRMM than without Dara. CMV infection was significantly common treated (16.98%) regimens (2.56%). During treatments, 24.53% developed and/or EBV infections. Patients who lower levels albumin lymphocytes their peripheral blood. median time from first infusion to 27 days. We observed NK...
Abstract Background Although the prognosis of Philadelphia‐positive acute lymphoblastic leukemia (Ph+ ALL) has improved with introduction tyrosine kinase inhibitors (TKIs) and stem cell transplantation, prevention relapse after transplantation remains a concern. The aim this study was to compare impact TKI prophylaxis imatinib dasatinib on long‐term outcomes transplantation. Methods Patients Ph+ ALL who underwent allogeneic hematopoietic (allo‐HSCT) at first complete remission (CR1) received...