A5005705124- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Mesenchymal stem cell research
- Long-Term Effects of COVID-19
- Congenital heart defects research
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Nuclear Receptors and Signaling
- Atrial Fibrillation Management and Outcomes
- Spinal Fractures and Fixation Techniques
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Impact on Reproduction
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Spine and Intervertebral Disc Pathology
- ATP Synthase and ATPases Research
- CRISPR and Genetic Engineering
- Microbial infections and disease research
- Peptidase Inhibition and Analysis
Harbin Medical University
2014-2025
First Affiliated Hospital of Harbin Medical University
2017-2025
First Affiliated Hospital of Hebei Medical University
2024
Hebei Medical University
2024
Nanjing Medical University
2024
Broad Institute
2024
Massachusetts Institute of Technology
2024
Jiangsu Province Hospital
2024
Weifang Medical University
2019-2021
Visual Sciences (United States)
2021
Abstract Tremendous efforts have been made to improve diagnosis and treatment of COVID-19, but knowledge on long-term complications is limited. In particular, a large portion survivors has respiratory complications, currently, experienced radiologists state-of-the-art artificial intelligence systems are not able detect many abnormalities from follow-up computerized tomography (CT) scans COVID-19 survivors. Here we propose Deep-LungParenchyma-Enhancing (DLPE), computer-aided detection (CAD)...
Cardiovascular disease plays a central role in the electrical and structural remodeling of right atrium, predisposing to arrhythmias, heart failure, sudden death. Here, we dissect with single-nuclei RNA sequencing (snRNA-seq) spatial transcriptomics gene expression changes human ex vivo atrial tissue pericardial fluid ischemic disease, myocardial infarction, non-ischemic failure using asymptomatic patients valvular who undergo preventive surgery as control group. We reveal substantial...
Background: This study investigates the clinical features and pulmonary functions of coronavirus disease 2019 (COVID-19) pneumonia survivors at 3 or 6 months after diagnosis in Heilongjiang Province, China. Methods: Forty-six patients with COVID-19 diagnosed starting from February 2020 were enrolled this for follow-up August 2020. These categorized into three groups: Group A ( n = 24) B 11), who moderate severe followed up diagnosis, C diagnosis. Pulmonary functions, arterial blood gas...
Background Liver ischemia reperfusion (I/R) injury is a common pathophysiological process in many clinical settings. Carvacrol, food additive commonly used essential oils, has displayed antimicrobials, antitumor and antidepressant-like activities. In the present study, we investigated protective effects of carvacrol on I/R Wistar rat livers an vitro hypoxia/restoration (H/R) model. Methods The hepatoportal vein, hepatic arterial duct rats were isolated clamped for 30 min, followed by 2 h...
This soft machine can pick up and release an ultrathin “living” cell sheet electronics without crumpling.
Adipose‑derived stem cells (ADSCs) and bone marrow‑derived (BMSCs) are considered to be prospective sources of mesenchymal stromal (MSCs), that can used in cell therapy for atherosclerosis. The present study investigated whether ADSCs co‑cultured with M1 foam macrophages via treatment oxidized low‑density lipoprotein (ox‑LDL) would lead similar or improved anti‑inflammatory effects compared BMSCs. ADSCs, peripheral blood monocytes, BMSCs ox‑LDL were isolated from ten coronary heart disease...
Background:Importin13 (IPO13) is a novel potential marker of corneal epithelial progenitor cells. We investigated the expression and localization IPO13 in endometrial, endometriotic endometrial carcinoma tissue.Material/Methods:IPO13 tissue was examined by immunohistochemistry, qPCR Western blot.Results:Immunohistochemistry studies showed that protein expressed mainly cytoplasm glandular cell stromal The rate importin13-positive cells proliferative phase endometrium higher (by about 6-fold)...
Surgical ventricular reconstruction (SVR) can restore cardiac function for left aneurysm to some extent. However, the patches used in this treatment have limitations such as stiffness and calcification. Engineering heart tissues (EHTs) emerged a promising biomaterial repair damaged heart. Nevertheless, selecting optimal candidate cells EHTs has been controversial. Aging is major consideration seed derived from elderly patients. Hence, study was aimed assess proliferation of, antiapoptosis...
Coronary artery disease (CAD) is a type of cardiovascular that greatly hurts the health human beings. Diabetic status one largest clinical factors affecting CAD-associated gene expression changes. Most studies focus on diabetic patients, whereas few have been done for non-diabetic patients. Since pathophysiological processes may vary among these we cannot simply follow standard based data from Therefore, prognostic and predictive diagnostic biomarkers CAD in patient need to be fully...
Highlights•Bulk and single-nucleus RNA-seq data from human atria help interpret AF GWAS results•Co-localization fine-mapping implicate 14 genes at 9 loci•LINC01629 is involved in the development of atrial tissue conduction systemSummaryAtrial fibrillation (AF) most common arrhythmia world. Human genetics can provide strong therapeutic candidates, but identification causal their functions remains challenging. Here, we applied an strategy that leverages results a previously published...
Septic cardiomyopathy (SC) is a rare and harmful cardiovascular disease with decreased left ventricular (LV) output multiple organ failure, which poses serious threat to human life. Despite the advances in SC, its diagnostic basis treatment methods are limited, specific biomarkers candidate regulatory targets have not yet been fully established. In this study, GSE79962 gene expression profile was retrieved, 20 patients SC 11 healthy donors as control. Weighted coexpression network analysis...
Adipose-tissue derived mesenchymal stem cell (ADSC)-based therapy is a promising option for patients with atherosclerotic conditions, including coronary artery disease. However, the potential differences in metabolic characteristics between bone marrow-derived cells (BMSCs) and ADSCs have remained to be fully elucidated. The present study aimed compare profiles of BMSCs via liquid chromatography quadrupole time-of-flight mass spectrometry. obtained from elderly heart disease were cultured,...
Cardiosphere-derived cells (CDCs) improve cardiac function and attenuate remodeling in ischemic non-ischemic cardiomyopathy, are currently obtained through myocardial biopsy. However, there is not any study on whether functional CDCs may be cadaveric autopsy with similar benefits cardiomyopathy.Cardiac tissues from human or mouse cadavers were harvested, plated at 4°C, removed varying time points to culture (CLH-EDCs) (CM-CDCs). The differentiation paracrine effects of also assessed....
Background . Engineered heart tissues (EHTs) present a promising alternative to current materials for surgical ventricular restoration (SVR); however, the clinical application remains limited by inadequate vascularization postimplantation. Moreover, suitable and economic animal model primary screening is another important issue. Methods Recently, we used 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride chemistry (EDC) initiate strengthened, cytokine-conjugated collagenous platform...
Morbidity and mortality associated with cardiovascular diseases, such as myocardial infarction, stem from the inability of terminally differentiated cardiomyocytes to regenerate, thus repair damaged tissue structure. The molecular biological mechanisms behind lack regenerative capacity for those remains be fully elucidated. Recent studies have shown that c-Jun serves a cell cycle regulator somatic fates, playing key role in multiple pathways, including inhibition cellular reprogramming,...
To assess the accuracy of serum procalcitionin (PCT) as a diagnostic marker in verifying upper and lower gastrointestinal perforation (GIP).
IL-35, a powerful suppressor of inflammation and autoimmunity, is primarily secreted by regulatory T cells (Tregs) can, in turn, promote Treg differentiation. However, the precise effect IL-35 on dendritic (DCs) remains to be clarified.In this study, we investigated expression DCs after stimulation with LPS utilizing enzyme linked immunosorbent assay(ELISA), quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) western blotting, influence maturation function mixed...