A5101495178- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Nuclear Receptors and Signaling
- Geomagnetism and Paleomagnetism Studies
- Atrial Fibrillation Management and Outcomes
- Genomics and Chromatin Dynamics
- Ionosphere and magnetosphere dynamics
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Cardiovascular Disease and Adiposity
- Single-cell and spatial transcriptomics
- Geophysics and Gravity Measurements
- Genetic Associations and Epidemiology
- Spine and Intervertebral Disc Pathology
- Congenital heart defects research
- RNA Research and Splicing
- Oropharyngeal Anatomy and Pathologies
- Cancer-related gene regulation
- Radiative Heat Transfer Studies
- Musculoskeletal pain and rehabilitation
- Photoacoustic and Ultrasonic Imaging
- Receptor Mechanisms and Signaling
- S100 Proteins and Annexins
- Medical Practices and Rehabilitation
- Spectroscopy Techniques in Biomedical and Chemical Research
Montreal Heart Institute
2019-2025
Université de Montréal
2021-2025
Canadian Memorial Chiropractic College
2015
Genome-wide association studies (GWAS) have identified hundreds of loci associated with coronary artery disease (CAD) and blood pressure (BP) or hypertension. Many these are not linked to traditional risk factors, nor do they include obvious candidate genes, complicating their functional characterization. We hypothesize that many GWAS vascular diseases modulate endothelial functions. Endothelial cells play critical roles in regulating homeostasis, such as forming a selective barrier,...
Abstract The dysregulation of gene expression programs in the human atria during persistent atrial fibrillation (AF) is not completely understood. Here, we reanalyze bulk RNA-sequencing datasets from two studies ( N = 242) and identified 755 differentially expressed genes left appendages individuals with AF non-AF controls. We combined a appendage single-nucleus multi-omics dataset to assign specific cell types. found noncoding at IFNG locus LINC01479 , IFNG-AS1 ) strongly dysregulated...
Highlights•Bulk and single-nucleus RNA-seq data from human atria help interpret AF GWAS results•Co-localization fine-mapping implicate 14 genes at 9 loci•LINC01629 is involved in the development of atrial tissue conduction systemSummaryAtrial fibrillation (AF) most common arrhythmia world. Human genetics can provide strong therapeutic candidates, but identification causal their functions remains challenging. Here, we applied an strategy that leverages results a previously published...
Abstract Epigenomic profiling, including ATACseq, is one of the main tools used to define enhancers. Because enhancers are overwhelmingly cell-type specific, inference their activity greatly limited in complex tissues. Multiomic assays that probe same nucleus both open chromatin landscape and gene expression levels enable study correlations (links) between these two modalities. Current best practices infer regulatory effect candidate cis -regulatory elements (cCREs) multiomic data involve...
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Introduction: Cellular senescence often involves a p16-pathway, and p16 overexpression is hallmark of senescent cells. The role cellular in myocardial infarction (MI) any mediating mechanisms remain unclear. Aims: To investigate the effect + cell clearance on survival post MI elucidate underlying mechanisms. Methods: We utilized INK-ATTAC transgenic mice, which cells undergo targeted apoptosis upon exposure to AP20187 (AP). Sham mice were treated with AP or vehicle (V) twice-weekly for one...
ABSTRACT Background Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with increased morbidity, mortality, and health-care costs. AF develops over many years often related to substantial atrial structural electrophysiological remodeling. may lack symptoms at onset biopsy samples are generally obtained in subjects advanced disease, so it difficult study earlier-stage pathophysiology humans. Methods Here, we characterized comprehensively transcriptomic (miRNAseq...
Introduction: Cellular senescence, a stress and age-related response, is often characterized by p16 expression in positive (p16 + ) senescent cells. Senescent cells secrete profibrotic proinflammatory factors as parts of “senescence associated secretory phenotype”. The role cellular senescence myocardial infarction (MI) unclear. Aims: To study the effect cell clearance on survival, cardiac remodeling function after MI. Methods: We used INK ATTAC transgenic mice, which undergo targeted...