A5101756134- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory Support and Mechanisms
- Acute Kidney Injury Research
- Water Treatment and Disinfection
- Inflammasome and immune disorders
- Thermal Regulation in Medicine
- Environmental Chemistry and Analysis
- Eicosanoids and Hypertension Pharmacology
- Intensive Care Unit Cognitive Disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Wastewater Treatment and Nitrogen Removal
- Sulfur Compounds in Biology
- Immune Response and Inflammation
- COVID-19 epidemiological studies
- Metabolomics and Mass Spectrometry Studies
- COVID-19 Impact on Reproduction
- SARS-CoV-2 detection and testing
- Vagus Nerve Stimulation Research
- Immune responses and vaccinations
- COVID-19 diagnosis using AI
- Nosocomial Infections in ICU
Harbin Medical University
2016-2025
First Affiliated Hospital of Harbin Medical University
2016-2025
Heilongjiang Provincial Hospital
2023-2025
Beijing University of Technology
2021-2024
Education Department of Heilongjiang Province
2024
People 's Hospital of Jilin Province
2024
National Health and Family Planning Commission
2021
Second Affiliated Hospital of Harbin Medical University
2020
Introduction Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology outcome severe septic shock mixed ICU China, as well independent predictors mortality. Methods We performed a 2-month prospective, observational cohort 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during period were screened patients with or included. Results A total 484 patients, 37.3 per 100 diagnosed...
Abstract Background Sepsis-associated acute kidney injury (SA-AKI) is a frequent complication in patients with sepsis and associated high mortality. Therefore, early recognition of SA-AKI essential for administering supportive treatment preventing further damage. This study aimed to identify validate metabolite biomarkers assist clinical diagnosis. Methods Untargeted renal proteomic metabolomic analyses were performed on the tissues LPS-induced mice. Glomerular filtration rate (GFR)...
Background Hydrogen sulfide (H2S) displays vasodilative, anti-oxidative, anti-inflammatory and cytoprotective activities. Impaired production of H2S contributes to the increased intrahepatic resistance in cirrhotic livers. The study aimed investigate roles carbon tetrachloride (CCl4)-induced hepatotoxicity, cirrhosis portal hypertension. Methods Findings Sodium hydrosulfide (NaHS), a donor H2S, DL-propargylglycine (PAG), an irreversible inhibitor cystathionine γ-lyase (CSE), were applied...
Hydrogen sulfide (H2S) displays anti-inflammatory and cytoprotective activities as evidenced by the inhibition of myocardial ischemia-reperfusion injury production lipid peroxidation. H2S also exerts many physiological or pathological effects on livers. Therefore, we designed present study to investigate roles in hepatic (HIR)–induced rats measuring levels, synthesizing activity, cystathionine γ-lyase (CSE) messenger RNA (mRNA) expression. We applied DL-propargyl glycine (PAG) sodium...
No therapeutics have been proven effective yet for the treatment of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). To assess efficacy and safety Triazavirin therapy COVID-19, we conducted a randomized, double-blinded controlled trial involving hospitalized adult patients with COVID-19. Participants were enrolled from ten sites, randomized into two arms study ratio 1:1. Patients treated 250 mg versus placebo three or four times day 7 d. The...
Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has spread, data on clinical characteristics of infected patients are limited. In this study, demographic, characteristics, and laboratory 310 SARS-CoV-2 treated at Haihe Hospital Tianjin were collected analyzed. Information these was compared to 96 with Delta concern (VOC) 326 Beta VOC during previous disease 2019 (COVID-19) outbreak in Harbin. Of variant, median age 35 years. Most clinically...
To establish a prediction model and assess the risk factors for severe diabetic ketoacidosis (DKA) in adult patients during ICU.With DKA hospitalization rates consistently increasing, in-hospital mortality has become growing concern.DKA aged >18 years old US-based critical care database (Medical Information Mart Intensive Care (MIMIC-IV)) were considered. Independent screened using extreme gradient boosting (XGBoost) Bayesian information criterion (BIC) optimal subset regression. One...
We sought to describe the demographics, case mix, interventions, and clinical outcome of critically ill patients admitted ICUs in Mainland China.A 2-month (July 1, 2009, August 31, 2009) prospective, observational cohort study.Twenty-two China.Adult participating during study period with an ICU length stay >24 hrs.None.Patient characteristics, including underlying diseases, severity illness, admission status, complications, intervention treatment stay, were recorded report form. The primary...
Abstract Coronavirus disease (COVID‐19) was first diagnosed in Wuhan December 2019. The World Health Organization defined the subsequent outbreak of COVID‐19 worldwide as a public health emergency international concern. Epidemiological data indicate that at least 20% patients have severe disease. In addition to impairment respiratory system, acute kidney injury (AKI) is major complication. Immune damage mediated by cytokine storms and concomitant AKI key factor for poor prognosis. Based on...
Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses septic with non-supervised learning algorithms, so as tailor for each class.Patients in 25 tertiary care teaching hospitals China from January 2016 December 2017 were enrolled the study. Clinical laboratory variables collected on days 0, 1, 2, 3 7 after ICU admission. Subclasses identified by both finite mixture modeling K-means...
Abstract Tremendous efforts have been made to improve diagnosis and treatment of COVID-19, but knowledge on long-term complications is limited. In particular, a large portion survivors has respiratory complications, currently, experienced radiologists state-of-the-art artificial intelligence systems are not able detect many abnormalities from follow-up computerized tomography (CT) scans COVID-19 survivors. Here we propose Deep-LungParenchyma-Enhancing (DLPE), computer-aided detection (CAD)...
Acute kidney injury (AKI), which is associated with high mortality rates, involves renal inflammation related to the activation of innate immunity. The inflammatory response in AKI inflammasome, integrates danger signals into caspase-1-activating platforms, leading processing and secretion proinflammatory cytokines interleukin (IL)-1β IL-18. nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome plays a role development many diseases, including AKI. However, mechanisms by...