A5101614175- Healthcare Systems and Reforms
- Cell death mechanisms and regulation
- Primary Care and Health Outcomes
- Climate Change and Health Impacts
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Immunotherapy and Immune Responses
- Healthcare professionals’ stress and burnout
- Hydropower, Displacement, Environmental Impact
- Transboundary Water Resource Management
- Air Quality and Health Impacts
- RNA modifications and cancer
- Workplace Violence and Bullying
- Cell Adhesion Molecules Research
- Cerebral Venous Sinus Thrombosis
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Glaucoma and retinal disorders
- SARS-CoV-2 detection and testing
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Health and Well-being Studies
Harbin Medical University
2016-2025
Second Affiliated Hospital of Harbin Medical University
2016-2025
Third Affiliated Hospital of Zhengzhou University
2024
GTx (United States)
2024
Zhengzhou University
2024
Academy of Medical Sciences
2024
State Key Laboratory of Medical Neurobiology
2023
Hangzhou Normal University
2023
Guangzhou University of Chinese Medicine
2023
Fudan University
2023
Workplace violence (WPV) is a global public health problem and has caused serious threat to the physical mental of healthcare workers. Moreover, WPV also an adverse effect on workplace behavior This study three purposes: (1) identify prevalence against physicians; (2) examine association between exposure WPV, job satisfaction, burnout turnover intention Chinese physicians (3) verify mediating role social support.A cross-sectional adopted purposive sampling method collect data from March 2017...
No therapeutics have been proven effective yet for the treatment of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). To assess efficacy and safety Triazavirin therapy COVID-19, we conducted a randomized, double-blinded controlled trial involving hospitalized adult patients with COVID-19. Participants were enrolled from ten sites, randomized into two arms study ratio 1:1. Patients treated 250 mg versus placebo three or four times day 7 d. The...
Objectives The sudden outbreak of the novel coronavirus disease (COVID-19) plunged healthcare workers (HCWs) into warfare. This study aimed to determine prevalence burnout and factors associated with it among frontline HCWs fighting COVID-19. Methods A cross-sectional survey was conducted against COVID-19 in Wuhan, Harbin, Shenzhen during period from February 18 March 4. Finally, were recruited using cluster sampling, 1,163 included final analysis. Burnout measured a 22-item Maslach...
China launched the primary health care (PHC) system oriented National Essential Public Health Service Package (NEPHSP) in 2009, to combat challenges including increasing burden from hypertension and type-2 diabetes (T2DM). In this study, PHC was assessed understand factors influencing uptake of NEPHSP for T2DM management.A mixed-methods study conducted seven counties/districts five provinces across mainland China. Data included a facility level survey interviews with policy makers,...
China's National Essential Public Health Service Package (NEPHSP) aims to promote health for all at the primary care level and includes a focus on hypertension type-2 diabetes mellitus (T2DM). However, there are limited contemporary data quantify cascades of T2DM in care.
In the present study we aimed to identify novel mechanisms and therapeutics for thoracic aortic aneurysm (TAA) in Fbn1C1039G/+ Marfan Syndrome (MFS) mice. The expression of mature/active TGFβ its downstream effector NOX4 were upregulated while tetrahydrobiopterin (H4B) salvage enzyme dihydrofolate reductase (DHFR) was downregulated vivo treatment with anti-TGFβ completely attenuated expression, restored DHFR protein abundance, reduced ROS production, recoupled eNOS formation. Intriguingly,...
Objective: Hospital violence remains a global public health problem. This study aims to analyze serious hospital causes in China and the characteristics of perpetrators. It likewise seeks understand frontline personnel's needs put forward targeted suggestions. Methods: Serious cases from 2011 2020 Judgment Online System (CJOS) were selected for descriptive statistical analysis. A total 72 doctors, nurses, managers, security personnel 20 secondary tertiary hospitals semi-structured...
Demethyleneberberine (DMB) is an essential metabolite of Berberine (BBR) in vivo. Recent reports have revealed multiple novel therapeutic applications BBR. However, the pharmacological activities DMB remain to be elucidated. This study aimed demonstrate hepatoprotective and anti-fibrotic effects both vitro Here we showed that protects against thioacetamide (TAA)-induced hepatic fibrosis mice exhibits a higher safety profile as compared Flow cytometry Western blotting analysis able suppress...
The association between low serum testosterone levels and all-cause mortality in male female patients with cardiovascular disease (CVD) was investigated. This study extracted data on CVD from the National Health Nutrition Examination Survey (NHANES) database (1999-2000, 2003-2004, 2011-2012, 2013-2014). (≤ 300 ng/dL) evaluated using univariate multivariate Cox regression analyses, hazard ratios (HR) 95% confidence intervals (CI). A total of 1,177 participants (689 males) a mean age 66.01 ±...
Staphylococcus aureus is the leading cause of many human infectious diseases. Besides dangers, S. well-known for quickly developed drug resistance. Although great efforts have been made, mechanisms underlying antibiotic effects are still not well clarified. Recently, reports shown that oxidative stress connects with bactericidal antibiotics [Dwyer et al. (2009) Curr. Opin. Microbiol. 12, 482–489]. Based on this point, we demonstrate reactive oxygen species (ROS) induced by sublethal...
Objective The purposes of this study were to evaluate the rate workplace violence in county hospitals China and its impact on healthcare workers explore relationship between hospital violence, coping styles anxiety provide effective procedures for reducing among workers. Methods used stratified sampling select 1200 from 30 conduct a questionnaire survey. Of these, 1030 valid questionnaires, response was 85.83%. We collected demographic characteristics our participants administered following...
Abstract Neuroinflammation plays important roles in retinal ganglion cell (RGC) degeneration glaucoma. MicroRNA‐146 (miR‐146) has been shown to regulate inflammatory response neurodegenerative diseases. In this study, whether and how miR‐146 could affect RGC injury chronic ocular hypertension (COH) experimental glaucoma were investigated. We showed that the members of family only miR‐146a‐5p expression was upregulated COH retinas. The upregulation observed activated microglia Müller cells...
Background Psoriasis is a chronic immune-mediated inflammatory disease. N6-methyladenosine (m6A) involved in numerous biological processes both normal and diseased states. Herein, we aimed to explore the potential role of m6A regulators diagnosis psoriasis predict molecular mechanisms by which impact psoriasis. Methods GSE30999 (170 human skin tissue samples) GSE13355 (180 were downloaded as training analysis dataset validation respectively. M6A-related genes obtained from literature their...
The coronavirus disease 2019 (COVID-19), a pneumonia caused by novel coronavirus, was reported in December 2019. COVID-19 is highly contagious and has rapidly developed from regional epidemic into global pandemic. As yet, no effective drugs have been found to treat this virus. This study, an ongoing multicenter blind randomized controlled trial (RCT), being conducted at ten study sites Heilongjiang Province, China, investigate the efficacy safety of Triazavirin (TZV) versus its placebo...
Progressive damage of retinal ganglion cells (RGCs) is observed in early diabetic retinopathy. Intracellular Ca2+ overload mediated by influx through voltage-gated channels (VGCCs) involved neurodegeneration, whereas glucagon-like peptide-1 (GLP-1) provides neuroprotection. However, whether GLP-1 plays a neuroprotective role retinas modulating VGCCs remains unknown. We found that eye drops exendin-4, long-acting receptor (GLP-1R) agonist, prevented the increase L-type current (ILCa)...
Background and aim Benchmarking is a management approach for implementing best medical practices at the lowest cost. The objectives of this study were to set achievable performance benchmarks individual quality indicators determine predicted achievement related better adherence, select optimal improving acute ischemic stroke care. Methods We analyzed data on 500,331 patients diagnosed with who treated 518 hospitals in China from January 2011 May 2017. primary outcome was independence...
Since 1951, the tuberculin PPD-S1 has been used to standardize commercial PPD reagents and perform special surveys. is now in short supply a new standard (PPD-S2) manufactured. To determine if PPD-S2 equivalent can replace PPD-S1, we conducted double-blind clinical trial. Between May 14 October 28, 1997, 69 subjects with history of culture-proven tuberculosis (TB patients) 1,189 very low risk for TB infection were enrolled, received four skin tests (with PPD-S2, one each commercially...