A5106541620- Neuroscience and Neuropharmacology Research
- Glaucoma and retinal disorders
- interferon and immune responses
- Ocular Surface and Contact Lens
- Sulfur Compounds in Biology
- Memory and Neural Mechanisms
- NF-κB Signaling Pathways
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease and Transplantation
- Eicosanoids and Hypertension Pharmacology
- Sleep and Wakefulness Research
- Retinal Diseases and Treatments
- Photoreceptor and optogenetics research
- Liver Disease Diagnosis and Treatment
- Microbial Natural Products and Biosynthesis
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Organ Transplantation Techniques and Outcomes
- Vestibular and auditory disorders
- Xenotransplantation and immune response
- Hearing, Cochlea, Tinnitus, Genetics
- Salivary Gland Disorders and Functions
- Traditional and Medicinal Uses of Annonaceae
University of South China
2012-2025
Huazhong University of Science and Technology
2021-2023
Central Hospital of Wuhan
2013-2023
First Affiliated Hospital of University of South China
2012-2023
Sichuan University
2022
West China Hospital of Sichuan University
2022
Army Medical University
2013-2015
First Affiliated Hospital of Harbin Medical University
2009-2014
Harbin Medical University
2009-2014
Sun Yat-sen University
2006
Background Hydrogen sulfide (H2S) displays vasodilative, anti-oxidative, anti-inflammatory and cytoprotective activities. Impaired production of H2S contributes to the increased intrahepatic resistance in cirrhotic livers. The study aimed investigate roles carbon tetrachloride (CCl4)-induced hepatotoxicity, cirrhosis portal hypertension. Methods Findings Sodium hydrosulfide (NaHS), a donor H2S, DL-propargylglycine (PAG), an irreversible inhibitor cystathionine γ-lyase (CSE), were applied...
Hydrogen sulfide (H2S) displays anti-inflammatory and cytoprotective activities as evidenced by the inhibition of myocardial ischemia-reperfusion injury production lipid peroxidation. H2S also exerts many physiological or pathological effects on livers. Therefore, we designed present study to investigate roles in hepatic (HIR)–induced rats measuring levels, synthesizing activity, cystathionine γ-lyase (CSE) messenger RNA (mRNA) expression. We applied DL-propargyl glycine (PAG) sodium...
Inflammatory response and cardiomyocyte apoptosis are important processes in ventricular remodeling post‑myocardial infarction (MI) may form the basic mechanisms development of chronic heart failure. The nuclear factor κB (NF‑κB) signaling pathway could promote inflammation it has been demonstrated that lycopene inhibits cigarette smoke extract‑mediated NF‑κB activation. Therefore, was hypothesized be a key target reversal post MI. An MI model established by left anterior descending coronary...
To investigate the potential regional homogeneity (ReHo) brain activity changes in patients with corneal ulcer (CU) and their possible relationship clinical symptoms.Forty CU (26 men 14 women), 40 healthy controls (HCs) women) closely matched age, sex, weight underwent resting-state functional MRI scans, respectively. The ReHo method was applied to evaluate synchronous neural changes. Receiver operating characteristic curve (ROC curve) used show high test-retest stability degree of...
To develop a new decellularization method depended upon the natural corneal structure and to harvest an ideal scaffold with good biocompatibilities for reconstruction.The acellular cornea matrix (ACM) were prepared from de-epithelium fresh porcine corneas (DFPCs) by incubation 100% human sera additional electrophoresis at 4°C. Human epithelial cells (HCEs) used cytotoxicity tests of ACM. ACM implanted into Enhanced Green Fluorecence Protein (eGFP) transgenic mouse anterior chamber evaluation...
In the present study, we investigated effects of chronic exposure (14 and 28 days) to a 0.5 mT 50 Hz extremely low-frequency magnetic field (ELM) on dendritic spine density shape in superficial layers medial entorhinal cortex (MEC). We performed Golgi staining reveal spines principal neurons rats. The results showed that ELM induced decrease dendrites stellate basal pyramidal at both 14 days days, which was largely due loss thin branched spines. alteration mushroom stubby post cell-type...
Abstract Only a few of studies have reported whether Tranexamic acid (TXA) has the same benefits during total ankle replacement as hip and knee replacements. In our study, we hypothesized that TXA was effective in reducing perioperative blood loss without increasing risk symptomatic venous thromboembolism patients replacement. We retrospectively reviewed 71 who underwent at foot surgery center institution between January 2017 May 2021. Patients were divided into two groups according to they...
Background Dilation resistance to stenting in non-calcified coronary plaques was compared patients with percutaneous intervention (PCI) order confirm the clinical usefulness of multislice computed tomography examining plaque type and provide information pertaining effects on dilatation resistance. Methods A retrospective analysis 64-slice imaging data collected month prior 93 (65 male 28 female, mean age (57.22±7.22) years) conducted. Non-calcified were divided into lipid-rich (lipid content...
To investigate the clinical effect of spanishneedles leaves on middle and severe xerophthalmia menopausal females.This study was a prospective random controlled trial. Ninty-six females diagnosed with xerophthalmnia (aged from 40 to 50) were randomly divided into in two groups: group A' (n=48) B' control (n=48). Both groups treated Forte eye drops. All patients detected at 3, 7, 28 h before after treatment evaluate subjective symptoms, OSDI four tear film indicators. Variance analysis...
Optical coherence tomography angiography (OCTA) is a rapid, noninvasive new blood flow imaging technique that was first applied to retinal retinopathy and acquired vascular in only few seconds.Compared with the traditional optical tomography(OCT), OCTA analyze has advantages of higher resolution, faster scanning speed, quantitative flow, etc.OCTA not can more accurately qualitatively ocular morphology, but also measure vessels perfusion noninvasively quantitatively.With application anti...
Objective To investigate the role of H2S in carbon tetrachloride (CC14)-induced cirrho-sis and portal hypertension.Methods 42 rats were divied into experimental group (n =36) control =6).The consisted 3 subgroups (each had 12 rats):saline,NaHS DL-propargylglycine (PAG),receiving intraperitoneal injections 1 ml salinc,NaHS solution (10 mmol/kg)and PAG (30 mg/kg) respectively.All given 50％ CCl4 (l ml/kg,twice a week).The equal quantity saline.After weeks,the indices for liver fibrosis...
Background Optic neuropathy is one of the diabetic eye complications.Rosiglitazone,a peroxisome proliferator activated receptor γ(PPARγ) agonist,plays a very important role in arresting pathogenesis and development diabetes.However,the PPARγ optic unclear.Objective This study was to investigate protective effect rosiglitazone against its mechanism.Methods Male Sprague-Dawley rats were randomly divided into control group,diabetic group group,with 10 for each group.Diabetic models induced by...
Abstract Background Litaf protein is a newly discovered inflammatory protein, whether it involved in the formation of atherosclerosis remains unclear; Methods Ten C57BL/6J mice and ten with knockout gene (C57BL/6J − Litaf− ) were purchased from Animal Culture Center Huazhong University Science Technology divided into two groups: control group −/− group. Animals given normal diet euthanized after 16-week culture. Mice, heart whole aorta isolated, aortic root mouse was taken for frozen...
Objective To investigate therapeutic efficiency of isoflavone on middle and severe dry eye menopause female. Methods A prospective random double-blind controlled study.Seventy-two cases diagnosed female (aged from 40 to 50 years old) in the First Affiliated Hospital Nanchang University August 2010 March 2011 were divided into two groups:isoflavone group control group,38 each group.All groups had 0.05％ refresh drops.All patients been detected evaluated by subjective symptoms eye,visual...