A5013022727- Congenital Heart Disease Studies
- Folate and B Vitamins Research
- Circular RNAs in diseases
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Atrial Fibrillation Management and Outcomes
- Galectins and Cancer Biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Imaging and Diagnostics
- Nuclear Receptors and Signaling
- Atherosclerosis and Cardiovascular Diseases
- ATP Synthase and ATPases Research
- Traditional Chinese Medicine Studies
- Bioinformatics and Genomic Networks
- Traditional Chinese Medicine Analysis
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- PI3K/AKT/mTOR signaling in cancer
Weifang Medical University
2014-2023
Abstract Background To assess the efficacy and safety of oral Guanxinshutong (GXST) capsules in Chinese patients with stable angina pectoris (SAP) a prospective, multicenter, double-Blind, placebo-controlled, randomized clinical trial ( clinicaltrials.gov Identifier: NCT02280850). Methods Eligible were 1:1 to GXST or placebo group. Current standard antianginal treatment except for nitrate drugs was continued both groups, who received an additional 4-week capsule placebo. Primary endpoint...
Coronary artery disease (CAD) is a type of cardiovascular that greatly hurts the health human beings. Diabetic status one largest clinical factors affecting CAD-associated gene expression changes. Most studies focus on diabetic patients, whereas few have been done for non-diabetic patients. Since pathophysiological processes may vary among these we cannot simply follow standard based data from Therefore, prognostic and predictive diagnostic biomarkers CAD in patient need to be fully...
Pulmonary artery hypertension (PAH) is a rare, life-limiting cardiopulmonary disorder characterized by the progressive and remodeling of pulmonary vasculature. Although development technology brings us many approaches for treatment PAH, effect unsatisfactory. Tripterygium wilfordii (TW), as traditional Chinese medicine (TCM), has been widely used in anti-inflammation, anticancer, other fields. However, potential TW treating PAH currently unclear.Active ingredients their corresponding genes...
Acute myocardial infarction (AMI) is one of the leading causes death and disability. The dysregulation cardiac endothelial cells plays a significant role in pathogenesis AMI. In present study, we investigated potential memantine, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used treatment Alzheimer's disease, to mitigate effects ischemia-reperfusion injury peripheral vasculature using human umbilical cord (HUVECs). Previous studies have identified anti-inflammatory...
Abstract Objectives Congenital heart diseases (CHD) are common birth defects in the world. The methylenetetrahydrofolate reductase (MTHFR) gene is one of most important candidate genes for development CHD. This case–control study aimed to evaluate effect MTHFR c.382A>G and c.1129C>T genetic polymorphisms as risk factors Methods A total 230 CHD patients 237 non-CHD controls were included present study. genotyping detected by polymerase chain reaction-restriction fragment length...
Sepsis is a life-threatening disease that damages multiple organs and induced by the host's dysregulated response to infection with high morbidity mortality. Heart remains one of most vulnerable targets sepsis-induced organ damage, cardiomyopathy (SIC) an important factor exacerbates death patients. However, underlying genetic mechanism SIC needs further research.The transcriptomic dataset, GSE171564, was downloaded from NCBI for analysis. Gene expression matrices sample group were obtained...