A5073212927- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Ovarian function and disorders
- Reproductive Biology and Fertility
- History and advancements in chemistry
- Menopause: Health Impacts and Treatments
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Various Chemistry Research Topics
- Effects and risks of endocrine disrupting chemicals
- Surface Chemistry and Catalysis
- Developmental Biology and Gene Regulation
- Pregnancy-related medical research
- Advanced Chemical Physics Studies
- Electrochemical Analysis and Applications
- Hormonal and reproductive studies
- Chemical Reactions and Isotopes
- Epigenetics and DNA Methylation
- Phytoestrogen effects and research
- Quantum, superfluid, helium dynamics
- Catalysis and Hydrodesulfurization Studies
Yale University
2016-2025
Maimonides Medical Center
2022
Yale New Haven Hospital
2005-2022
Neurotech (United States)
2022
Monash University
2022
University of Chicago
1974-2022
Eastern Virginia Medical School
2018-2022
Mercy Health
2018-2022
American Society for Reproductive Medicine
2018-2022
Mayo Clinic
2022
Endometriosis can have a profound impact on women's lives, including associated pain, infertility, decreased quality of life, and interference with daily relationships, livelihood. The first step in alleviating these adverse sequelae is to diagnose the underlying condition. For many women, journey endometriosis diagnosis long fraught barriers misdiagnoses. Inherent challenges include gold standard based an invasive surgical procedure (laparoscopy) diverse symptomatology, contributing...
The problem of the mechanism a catalytic action occurring at surface solid catalyst can be studied in several ways. Kinetic studies such reactions supply important information with regard to manner by which process is achieved. On other hand, attention may focussed, not on occur surface, but properties itself, and, from results studies, generalizations made respect variety surface. It this latter method attack contact catalysis has been adopted last few years comprehensive series...
STUDY QUESTIONWhat is the global consensus on classification of endometriosis that considers views women with endometriosis?
Neurobehavioral disorders are increasingly prevalent in children, however their etiology is not well understood. An association between prenatal cellular telephone use and hyperactivity children has been postulated, yet the direct effects of radiofrequency radiation exposure on neurodevelopment remain unknown. Here we used a mouse model to demonstrate that in-utero from telephones does affect adult behavior. Mice exposed were hyperactive had impaired memory as determined using object...
Regeneration of the endometrium in each menstrual cycle is required for reproduction. Endogenous endometrial stem cells reside basalis layer and serve as a source that differentiate to form endometrium. Bone marrow-derived have been shown take on functions outside hematopoietic system.To investigate possibility extrauterine origin could repopulate endometrium.Endometrium from 4 HLA-mismatched bone marrow transplant recipients (1998-2002) was evaluated donor HLA expression. Each recipient had...
The mammalian female reproductive system arises from the uniform paramesonephric duct. molecular mechanisms that establish differential development along this axis are unknown. We determined pattern and timing of genes Hoxa in Müllerian tract. Hoxa-9, Hoxa-10, Hoxa-11, Hoxa-13 all expressed length duct embryonic mouse. After birth, a spatial Hox is established, corresponding to postnatal differentiation organ Hoxa-9 fallopian tubes, Hoxa-10 uterus, Hoxa-11 uterus uterine cervix, upper...
BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case second trimester with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.
Abstract Bone marrow-derived cells (BMDCs) can differentiate into nonhematopoietic cells, suggesting that BMDCs may contribute to the maintenance of multiple tissues. Donor-derived bone marrow have been identified in human uterine endometrium. Here, two murine models were used investigate contribution nonendometrial stem We whether localize endometrium and endometriosis. After transplantation, male donor-derived found female mice. Although uncommon (<0.01%), these epithelial cells....
Background Menopausal hormone therapy (MHT) reportedly increases the risk of cognitive decline in women over age 65 y. It is unknown whether similar risks exist for recently postmenopausal women, and MHT affects mood younger women. The ancillary Cognitive Affective Study (KEEPS-Cog) Kronos Early Estrogen Prevention (KEEPS) examined effects up to 4 y on cognition Methods Findings KEEPS, a randomized, double-blinded, placebo-controlled clinical trial, was conducted at nine US academic centers....
Previous studies have shown that triggering multiple myeloma (MM) cells via CD40 induces IL-6-mediated autocrine growth as well increased expression of cell surface adhesion molecules including CD11a, CD11b, CD11c, and CD18. In this study, we generated the 5E2 mAb which targets an antigen is induced upon ligand (CD40L) activation MM cells. Immunofluorescence, immunoprecipitation, protein sequencing identified target 86-kD subunit Ku autoantigen. We demonstrate on CD40L-treated due to...
Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Elagolix, an oral, nonpeptide, gonadotropin-releasing hormone (GnRH) antagonist, produced partial to nearly full estrogen suppression in previous studies.We performed two similar, double-blind, randomized, 6-month phase 3 trials (Elaris I II [EM-I EM-II]) evaluate the effects of doses elagolix - 150 mg once daily (lower-dose group) 200 twice (higher-dose as compared with placebo women...
Whether menopausal hormone therapy (MHT) protects against cardiovascular disease (CVD) remains unclear.To assess atherosclerosis progression and CVD risk factors after MHT initiated in early menopause.Randomized, controlled trial. (ClinicalTrials.gov: NCT00154180).Nine U.S. academic centers.Healthy women aged 42 to 58 years between 6 36 months from last menses without prior events who had a coronary artery calcium (CAC) score less than 50 Agatston units not received estrogen or...
Bisphenol-A (BPA) is a nonsteroidal estrogen that ubiquitous in the environment. The homeobox gene Hoxa10 controls uterine organogenesis, and its expression affected by utero BPA exposure. We hypothesized an epigenetic mechanism underlies BPA-mediated alterations expression. analyzed pattern methylation profile of after Pregnant CD-1 mice were treated with (5 mg/kg IP) or vehicle control on d 9–16 pregnancy. mRNA protein increased 25% reproductive tract exposed utero. Bisulfite sequencing...