A5037663109- Adipose Tissue and Metabolism
- Coronary Interventions and Diagnostics
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related molecular mechanisms research
- Advanced Materials and Mechanics
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Regulation of Appetite and Obesity
- Electrospun Nanofibers in Biomedical Applications
- Coal Properties and Utilization
- Video Surveillance and Tracking Methods
- Geoscience and Mining Technology
- Adipokines, Inflammation, and Metabolic Diseases
- Thermal Radiation and Cooling Technologies
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Micro and Nano Robotics
- Protease and Inhibitor Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Lipoproteins and Cardiovascular Health
- Radiomics and Machine Learning in Medical Imaging
- Viral Infectious Diseases and Gene Expression in Insects
Institute of Solid State Physics
2022-2025
Chinese Academy of Sciences
2010-2025
China Coal Research Institute (China)
2017-2025
Yunnan University
2025
Center for Life Sciences
2025
Qingdao University
2021-2024
Affiliated Hospital of Qingdao University
2021-2024
The Ohio State University
2010-2024
Sir Run Run Shaw Hospital
2020-2024
Zhejiang University
2020-2024
The liquid metal hydrogel with multiple physical cross-links possesses super-stretchability, notch resistance, self-healing properties, and photothermal which give it the potential for human–computer interaction infrared camouflage.
Rationale: Tolerogenic dendritic cells (tol-DCs) play essential roles in immune-related diseases and induce immune tolerance by shaping T-cell responses.Accumulating evidence suggests that long noncoding RNAs (lncRNAs) important regulatory the system.However, potential underlying mechanisms of lncRNAs tol-DCs remain unclear.Methods: RNA in-situ hybridization, histochemistry, qRT-PCR were performed to determine distribution expression NEAT1 DCs.Flow cytometry was used analyze tolerogenic...
Abstract Asymmetric‐expansion photothermal actuators have attracted the attention of researchers owing to their simple structure, superior stability, rapid response, and precise controllability. However, response speed, deformation capacity, load‐carrying capacity are mutually constrained by thickness. Inspired veins pulp in plant leaves, this study uses laser etching apply a superstructure ordered grooves liquid metal (LM) actuators. The resulting LM@low‐expansion polyimide (4.52 ppm K −1...
A simple and effective route is presented for the fabrication of polyacrylonitrile (PAN)/ferrous chloride (FeCl2) composite porous nanofibers based on electrospinning technology. The obtained are amorphous nanoporous in structure, 100–300 nm diameter 10 m2 g−1 specific surface area. Importantly, such PAN/FeCl2 have exhibited excellent performance Cr-removal from a Cr2O72−-containing solution one step. capability more than 110 mg Cr/g FeCl2, which much higher previously reported values other...
By shaping T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the induction of immune tolerance after transplantation. However, role long noncoding RNAs (lncRNAs) function and (DCs) is largely unknown. Here, we found that lncRNA MALAT1 upregulated infiltrating tolerized mice with cardiac allografts activated DCs. Functionally, overexpression favored a switch DCs toward tolerant phenotype. Mechanistically, ectopic promoted cell-specific intercellular adhesion...
Abstract Living in an enriched environment (EE) decreases adiposity, increases energy expenditure, causes resistance to diet induced obesity, and induces brown-like (beige) cells white fat via activating a hypothalamic-adipocyte axis. Here we report that EE stimulated vascular endothelial growth factor (VEGF) expression depot-specific manner prior the emergence of beige cells. The VEGF up-regulation was independent hypoxia but required intact sympathetic tone adipose tissue. Targeted...
Design of a hierarchical and interlock structure based on PVDF electrospinning film, which combines the remarkable features excellent radiation cooling, self-cleaning, enhanced mechanical properties.
Programmed cell death-4 (PDCD4), a selective protein translation inhibitor, has shown proinflammatory effect in some inflammatory diseases, but its roles obesity remain unestablished. This study aims to investigate the effects of PDCD4 on obesity, inflammation, and insulin resistance. Surprisingly, high-fat diet (HFD)-fed PDCD4-deficient (PDCD4−/−) mice exhibited an absolutely lean phenotype together with improved sensitivity. Compared wild-type obese mice, HFD-fed PDCD4−/− showed higher...
Abstract Macroenvironmental factors, including a patient's physical and social environment, play role in cancer risk progression. Our previous studies show that living an enriched environment (EE) providing complex stimuli confers anticancer phenotype mice mediated, part by specific neuroendocrine axis, with brain-derived neurotrophic factor (BDNF) as the key brain mediator. Here, we investigated how EE modulated T-cell immunity its EE-induced effects. data demonstrated CD8 T cells were...
Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors development age-related neuroinflammation and microglial dysfunction. EE results improvements learning memory, metabolism, mental health variety animal models. We recently reported that implementing middle age promotes healthy aging. In present study, we investigated whether...
Abstract Photothermal actuators are widely applied in robots, smart devices, and bionic systems. However, asymmetric thermal expansion, the most common mechanism for preparing photothermal actuators, has not been utilized programmable liquid metal actuators. In this work, Liquid metal/Polyimide/Polytetrafluoroethylene (LM/PI/PTFE) based on expansion prepared inspired by climbing plant tendrils. The “protoplasm that can contract bend” PTFE tape endows actuator with initial morphology....
Activation of the hypothalamus-adipocyte axis is associated with an antiobesity and anticancer phenotype in animal models melanoma colon cancer. Brain-derived neurotrophic factor (BDNF) a key mediator hypothalamus leading to preferential sympathoneural activation adipose tissue ensuing resistance obesity Here, we generated middle age obese mice by high fat diet feeding for year investigated effects hypothalamic gene transfer BDNF on hormone receptor-positive mammary tumor model. The...
Abstract The aging process and age‐related diseases all involve perturbed energy adaption impaired ability to cope with adversity. Brain‐derived neurotrophic factor (BDNF) in the hypothalamus plays important role regulation of balance. Our previous studies show that recombinant adeno‐associated virus (AAV)‐mediated hypothalamic BDNF gene transfer alleviates obesity, diabetes, metabolic syndromes both diet‐induced genetic models. Here we examined efficacy safety a built‐in autoregulatory...
// Zequn Li 1 , Chun Guo Xianglan Liu Chengjun Zhou 2 Faliang Zhu Xiaoyan Wang Qun Yongyu Shi Jianing Wei Zhao Lining Zhang Department of Immunology, Shandong University School Medicine, Jinan, China Pathology, The Second Hospital University, Correspondence to: Zhang, email: zhanglining@sdu.edu.cn Keywords: TIPE2, NSCLC, angiogenesis, invasiveness, Rac1 Received: September 22, 2015 Accepted: August 08, 2016 Published: 19, ABSTRACT Non-small cell lung cancer (NSCLC) is one the leading causes...
Abstract The long noncoding RNA antisense in the INK4 locus (ANRIL) plays a critical role development of atherosclerosis. However, precise effect ANRIL on endothelial dysfunction remains unclear. In this study, we investigated expression patients with coronary artery disease and elucidated molecular mechanism underlying its effect. was detected blood plasma 111 patients. We analysed correlation between markers. also examined regulation dysfunction. levels were increased acute syndrome. is...