A5100627268- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Thyroid and Parathyroid Surgery
- Cardiac Ischemia and Reperfusion
- Thyroid Cancer Diagnosis and Treatment
- Iron Metabolism and Disorders
- Water Treatment and Disinfection
- Fungal Infections and Studies
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- Antifungal resistance and susceptibility
First Affiliated Hospital of GuangXi Medical University
2012-2025
Guangxi Medical University
2013-2025
Guangxi Zhuang Autonomous Region Department of Education
2025
Central Hospital of Zibo
2025
University of Washington Medical Center
2025
Harbin Medical University
2018-2024
Second Affiliated Hospital of Harbin Medical University
2018-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2023-2024
Hohhot First Hospital
2024
Shanghai Ninth People's Hospital
2024
Rationale: Tolerogenic dendritic cells (tol-DCs) play essential roles in immune-related diseases and induce immune tolerance by shaping T-cell responses.Accumulating evidence suggests that long noncoding RNAs (lncRNAs) important regulatory the system.However, potential underlying mechanisms of lncRNAs tol-DCs remain unclear.Methods: RNA in-situ hybridization, histochemistry, qRT-PCR were performed to determine distribution expression NEAT1 DCs.Flow cytometry was used analyze tolerogenic...
Aim: The optimal maintenance therapy for active diffuse lupus nephritis remains to be established. In this study, we explored the efficacy and safety of tacrolimus maintaining remission compared that azathioprine. Methods: Seventy patients with biopsy-proven who achieved were enrolled in nine nephrology centers China from 2006 2008. Patients randomized either plus prednisone ( n = 34) or azathioprine 36) six months. Tacrolimus was titrated achieve a trough blood concentration 4–6 ng/mL,...
By shaping T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the induction of immune tolerance after transplantation. However, role long noncoding RNAs (lncRNAs) function and (DCs) is largely unknown. Here, we found that lncRNA MALAT1 upregulated infiltrating tolerized mice with cardiac allografts activated DCs. Functionally, overexpression favored a switch DCs toward tolerant phenotype. Mechanistically, ectopic promoted cell-specific intercellular adhesion...
Heart failure (HF) is a principal cause of morbidity and mortality worldwide, affecting an estimated 38 million people. Although significant progress has been made with respect to the underlying molecular mechanisms, role competing endogenous RNA (ceRNA) network in pathogenesis HF remains largely unknown. In this study, HF‑associated ceRNA was constructed based on differentially expressed long noncoding RNAs (lncRNAs), microRNAs (miRNAs) mRNAs obtained, respectively, from GSE77399, GSE104150...
Serum concentrations of bilirubin, albumin, and uric acid (UA) play important roles in controlling oxidative stress. Until now, there are few researches related to the relationship between stress Crohn's disease (CD); furthermore, no such study has been reported from China. Our aim was evaluate serum UA levels CD patients relate them activity.Seventy-one diagnosed with 125 sex- age-matched healthy individuals were retrospectively analyzed during same period. Clinical characteristics...
Long noncoding RNAs (lncRNAs) have emerged to irreplaceable roles in the epigenetic regulation of cancer progression, but their biological functions colorectal (CRC) remain unclear.LncRNA expression profiles CRC tissue and normal counterpart were explored. Through gain loss function approaches, role lncRNA PTTG3P was validated relevant cells subcutaneous tumor model. The correlations with clinical outcomes assessed.PTTG3P upregulated tissues closely correlated unsatisfactory prognosis....
Exosomes secreted by glioma cells can carry a number of bioactive molecules. As the most abundant noncoding RNA in exosomes, microRNAs (miRNAs) are involved signaling between tumor ways. In addition, hypoxia is an important feature microenvironment tumors. The present study investigated effect miR‑29a‑3p exosomes on proliferation and apoptosis levels U251 under hypoxia. Qualitative PCR results showed that expression level plasma patients was lower than normal subjects. By conducting...
Noncoding variants are critical to our understanding of the genetic basis diseases and disorders such as rheumatoid arthritis (RA). While genome-wide association studies have identified regions genome associated with disease, functional still lagging that can identify potentially causative variants. In order functionally fine-map RA-associated variants, we at enhancers marked in primary activated T helper cells conducted massively parallel reporter assay these cells. We found combinations...
Expression of the transcription factor hypoxiainducible 1 (HIF-1) plays a key role in cellular adaptation to hypoxia, particularly relation tumour angiogenesis. HIF-1α subunit is responsive changes oxygen levels. Overexpression has been reported be associated with poor prognosis variety malignant tumours. The objective this study was investigate whether expression tongue carcinoma established clinicopathological features. Tumour specimens from 120 patients histologically-proven,...
Oxidative stress and low antioxidant status are implicated in the pathogenesis of inflammatory autoimmune diseases. Pemphigus vulgaris (PV) is an extremely severe bullous dermatosis characterized by intraepithelial bullae on skin mucosa, its not fully understood.To assess correlations between PV serum levels bilirubin, uric acid (UA) albumin.We enrolled 116 patients newly diagnosed with who were admitted to First Affiliated Hospital Guangxi Medical University (Guangxi, China), 108 healthy...
Ferroptosis-related lncRNAs are promising biomarkers for predicting the prognosis of many cancers. However, a ferroptosis-related signature to predict cutaneous melanoma (CM) has not been identified. The purpose this study was construct lncRNA and immunotherapy efficacy in CM.Ferroptosis-related differentially expressed genes (FDEGs) (FDELs) were identified using TCGA, GTEx, FerrDb datasets. We performed Cox LASSO regressions identify key FDELs, constructed risk score stratify patients into...
Cell apoptosis is one of the main pathological alterations during oxidative stress (OS) injury. Previously, we corroborated that nuclear factor-κB (NF-κB) transactivation confers resistance against OS in mammalian cells, yet underlying mechanisms remain enigmatic. Here report microRNA-19a (miR-19a) transcriptionally regulated by reactive oxygen species (ROS) production and NF-κB deactivation prevents OS-initiated cell through cylindromatosis (CYLD) repression. CYLD contributes to apoptosis,...
Raised triglycerides (TG) and reduced high density lipoprotein cholesterol (HDL-c) are components of metabolic syndrome. Both TG syndrome have been reported to be risk factors endometrial cancer. Therefore, triglycerides-to-high ratio (TG/HDL-c ratio) may a useful biological indicator in managing We aimed explore the association between pretreatment TG/HDL-c cancer postmenopausal women, evaluate its potential role disease. Pretreatment serum lipid profile were retrospectively analyzed for...
Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive disease that leads to an increased disability rate. This study aimed ascertain biomarkers, infiltrating immune cells, and therapeutic drugs for SONFH. The gene expression profile GSE123568 dataset was downloaded from Gene Expression Omnibus (GEO) database. differentially expressed genes (DEGs) were identified using NetworkAnalyst platform. Functional enrichment, protein-protein interaction network (PPI), module...
The Hippo pathway was originally identified in Drosophila as the signalling that governs organ size. core of harbours two protein kinases (Hippo and Warts). phosphorylates activates Warts, which turn inactivates transcriptional co-activator Yorkie. As Yorkie mediates cell cycle-promoting anti-apoptotic gene transcriptions, suppresses cycle progression induces apoptosis. named after Hippo, regarded a key component. initially considered to be well conserved mammals. Indeed mammalian homologues...