A5101895177- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Natural Compounds in Disease Treatment
- Cancer Immunotherapy and Biomarkers
- Tea Polyphenols and Effects
- Chemokine receptors and signaling
- Phytochemicals and Antioxidant Activities
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- Hematopoietic Stem Cell Transplantation
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Fungal Biology and Applications
- Extracellular vesicles in disease
- Fermentation and Sensory Analysis
- Advanced Cellulose Research Studies
- RNA Research and Splicing
- Occupational and environmental lung diseases
- RNA Interference and Gene Delivery
Anhui Agricultural University
2023-2025
Yunnan Agricultural University
2024
China Pharmaceutical University
2018-2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Ministry of Agriculture and Rural Affairs
2024
Guangzhou Medical University
2024
Second Military Medical University
2012-2023
Kunming Medical University
2019
Massachusetts General Hospital
2017-2018
Long noncoding RNAs (lncRNAs) play important roles in diverse biological processes; however, few have been identified that regulate immune cell differentiation and function. Here, we lnc-DC, which was exclusively expressed human conventional dendritic cells (DCs). Knockdown of lnc-DC impaired DC from monocytes vitro mouse bone marrow vivo reduced capacity DCs to stimulate T activation. mediated these effects by activating the transcription factor STAT3 (signal transducer activator 3). bound...
Blockade of immune-checkpoint programmed cell death protein 1 (PD-1) or ligand can enhance effector T-cell responses. However, the lack response in many patients to checkpoint-inhibitor therapies emphasizes need for combination immunotherapies pursue maximal antitumor efficacy. We have previously demonstrated that antagonism C-X-C chemokine receptor type 4 (CXCR4) by plerixafor (AMD3100) decrease regulatory T (T
Tumors can induce generation and accumulation of the immunosuppressive cells such as regulatory T in tumor microenvironment, contributing to escape from immunological attack. Although dendritic cell (DC)-based cancer vaccine initiate antitumor immune response, DC subsets involved tolerance induction attracted much attention recently. Our previous studies demonstrate that stromal microenvironment spleen, lung, liver program CD11c(low)CD11b(high)Ia(low) DCs with function (CD11b(high)Ia(low)...
The classical activation of macrophages, one major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). priming effect can promote macrophages to secrete higher level proinflammatory cytokines but lower the anti-inflammatory cytokines, enhancing microbicidal tumoricidal activity macrophages. However, underlying molecular mechanisms for IFN-γ-priming on macrophage remain be fully understood. microRNAs (miRNAs) are now emerging as important...
// Ha Zhu 1 , Yan Gu Yiquan Xue Ming Yuan Xuetao Cao and Qiuyan Liu National Key Laboratory of Medical Immunology Institute Immunology, Second Military University, Shanghai 200433, China Correspondence to: Liu, email: liuqy@immunol.org Keywords: CXCR2 + MDSCs; breast cancer; tumor metastasis; EMT; T cells exhaustion Received: June 13, 2017 Accepted: November 14, Published: December 07, 2017 ABSTRACT Although myeloid-derived suppressor (MDSCs) have been...
Mesenchymal stem cells (MSCs) have been demonstrated to be involved in tumor progression and the modulation of microenvironment, partly through their secretome. Extracellular vesicles (EVs) are membranous nanovesicles secreted by multiple types mediate intercellular communication both physiological pathological conditions. However, numerous questions still remain regarding underlying mechanisms functional consequences these interactions. The purpose this study was investigate effects human...
RNA-binding proteins (RBPs) play important roles in cancer development and treatment. However, the tumor-promoting RBPs their partners, which may potentially serve as therapeutic targets, need to be further identified. Here, we report that zinc finger CCHC domain-containing protein 4 (ZCCHC4) is of aberrantly high expression multiple human tissues associated with poor prognosis chemoresistance patients hepatocellular carcinoma (HCC), pancreatic colon cancer. ZCCHC4 promotes HCC cells...
Abstract Fas/FasL system has been extensively investigated with respect to its capacity induce cellular apoptosis. However, accumulated evidences show that Fas signaling also exhibits nonapoptotic functions, such as induction of cell proliferation and differentiation. Lung cancer is one cancer’s refractory the immunotherapy, however, underlying mechanisms remain be fully understood. In this study, we overexpression does not affect in vitro growth 3LL cells, but promotes lung vivo....
Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play key multiple aspects cancer biology. Here, we detected chemokine CXCL1 was dramatically elevated serum from 3LL tumor-bearing mice. In vitro , cells constitutively expressed secreted higher level CXCL1....
Withering leads to the formation of high-quality flavor in black tea. This study investigated effects natural withering (NW), sun (SW), and warm-air (WW) on compounds withered leaves by using target metabolomic transcriptomic approaches. The results revealed that 4282, 4770, 1246 differentially expressed genes (DEGs) were identified NW, SW, WW samples, respectively. expression DEGs involved volatile compound flavonoid biosynthesis was highest sample, which may be main reason for significant...
Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has been demonstrated to suppress tumor growth and modulate intratumoral T-cell trafficking. However, the effect of on immunomodulation remains elusive. Here, we explored antitumor efficacy in combination with previously developed mesothelin-targeted, immune-activating fusion protein, VIC-008, two syngeneic, orthotopic models malignant mesothelioma immunocompetent mice. We showed that therapy significantly suppressed prolonged animal...
Ripening is a key process driving the transformation of non-volatiles in Keemun congou black tea (KCBT), affecting its flavour profile and health functions. In this study, taste was quantitatively evaluated by using sensory biomimetic electrodes employing metabolomic techniques. The results revealed that content polyphenols greatly affected ripening, catechins flavonoids reduced 63.5 % 9.2 %, respectively, theaflavins increased 14.6 thereby attenuating bitterness astringency infusion while...
<title>Abstract</title> Uveal melanoma (UM) is the most frequent primary intraocular malignancy in adults with high metastasis and mortality rate, whose effective therapeutic strategy still urgent need. Specifically, apoptosis-resistance a great challenge for advanced UM patients, therefore novel options targeting otherwise death modality, which may potentially enhance treatment effect, need to be further identified. Here, by kinase inhibitor library of 113 approved drugs screening, JTC801,...