A5100456437- Sperm and Testicular Function
- Sexual function and dysfunction studies
- Reproductive Biology and Fertility
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Sexuality, Behavior, and Technology
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Genital Health and Disease
- Spondyloarthritis Studies and Treatments
- Sexual Differentiation and Disorders
- Male Reproductive Health Studies
- Urologic and reproductive health conditions
- High-Energy Particle Collisions Research
- Rheumatoid Arthritis Research and Therapies
- Ovarian function and disorders
- Tracheal and airway disorders
- Urinary Bladder and Prostate Research
- Attention Deficit Hyperactivity Disorder
- Endometrial and Cervical Cancer Treatments
- Bipolar Disorder and Treatment
- Epilepsy research and treatment
- Schizophrenia research and treatment
Longgang Central Hospital
2025
Tongji Hospital
2013-2025
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
University of Science and Technology of China
2024-2025
Wenzhou Medical University
2018-2025
Xingtai People's Hospital
2025
Sichuan Agricultural University
2014-2025
Tianjin Medical University Cancer Institute and Hospital
2022-2025
Ministry of Agriculture and Rural Affairs
2023-2025
PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles the initiation of inflammation and pain. In present study, we evaluated role COX-2-derived PGE2 an animal model established hyperalgesia. Inflammation hyperalgesia were first induced by injection carrageenan into rat footpads. Then investigated effects subsequent therapeutic treatment with a selective COX inhibitor, nonsteroidal anti-inflammatory drug anti-PGE2 antibody. Test compounds administered 1 to 3 hr...
Hepatocellular carcinoma (HCC) is one of the most prevalent causes cancer-related morbidity and mortality worldwide. Late-stage detection complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. Dysregulated R-loops, three-stranded nucleic acid structures associated with genome instability, play a key role in malignant characteristics various tumors. However, detailed mechanism R-loops HCC remain elusive require further exploration. This study...
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor formation. Here, we report breast cancer metastasis. overexpression enhanced mammary migration by dephosphorylation activation of cofilin, which facilitates actin reorganization polymerization. Cofilin knockdown impaired Aur-A-driven protrusion membrane. Conversely, activated cofilin...
Due to lower farrowing rate and reduced litter size with frozen-thawed semen, over 90% of artificial insemination (AI) is conducted using liquid stored boar semen. Although substantial progress has been made towards optimizing the cryopreservation protocols for sperm, influencing factors underlying mechanisms related cryoinjury freeze tolerance sperm remain largely unknown. In this study, we report differential expression mRNAs miRNAs between fresh high-throughput RNA sequencing. Our results...
Endometriosis is a complex and enigmatic disease that arises from the interplay among multiple genetic environmental factors. The defining feature of endometriosis deposition growth endometrial tissues at sites outside uterine cavity. Studies to date have established heritable but not addressed causal variants for this disease. Here, we conducted whole-exome sequencing comprehensively search somatic mutations in both eutopic ectopic endometrium 16 patients five normal control using laser...
Routine semen parameters have limited clinical diagnostic value for predicting male infertility. The aim of this study was to investigate the association between sperm DNA fragmentation index (DFI) and quality, DFI pregnancy rate in vitro fertilization (IVF) intracytoplasmic injection (ICSI). A total 390 couples undergoing prior receiving conventional IVF (n = 238) or ICSI 152) were evaluated. We found that there no significant differences rate, good embryo high (≥30%) low (<30%) groups...
Capacitation, a prerequisite for oocyte fertilization, is complex process involving series of structural and functional changes in sperms such as membrane modifications, modulation enzyme activities, protein phosphorylation. In order to penetrate fertilize an oocyte, mammalian must undergo capacitation. Nevertheless, the sperm capacitation remains poorly understood requires further elucidation. current study, via high throughput sequencing, we identified explored differentially expressed...
// Meixiang Sang 1, 7, * , Mohit Hulsurkar 5, Xiaochong Zhang Haiping Song 8 Dayong Zheng 9 Yan 10 Min Li 2 Jianming Xu 3 Songlin Michael Ittmann 4 Wenliang 6 1 Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University Health Science Center at Houston, TX, USA Department Pathology and Laboratory Cell Biology, Baylor College Immunology, E. DeBakey VAMC, 5 Graduate School Biomedical Sciences, Division Oncology, Internal Memorial Herman Cancer Center, 7 Tumor...
Testosterone is overwhelmingly important in regulating erectile physiology. However, the associated molecular mechanisms are poorly understood. The purpose of this study was to explore effects and testosterone dysfunction (ED) castrated rats. Forty male Sprague-Dawley rats were randomized four groups (control, sham-operated, castration castration-with-testosterone-replacement). Reactive oxygen species (ROS) production measured by dihydroethidium (DHE) staining. Erectile function assessed...
N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of on reducing risk exacerbations in bronchiectasis patients. A prospective, randomized, controlled trial was conducted between April 1, 2014 and December 31, 2016 five general hospitals Shandong Province, China. Adult patients with at least two past year were potentially eligible. Patients randomly assigned receive oral (600 mg, twice daily, 12 months) or on-demand treatment. total 161 eligible for...
Premature ejaculation (PE), despite its wide prevalence, is largely underdiagnosed and undertreated. Being a multifactorial dysfunction with strong cultural characteristics, PE requires skillful attitudes in the psychosexological support, necessary to manage patient's couple's expectations, as well medical treatment. Dapoxetine short‐acting selective serotonin reuptake inhibitor approved for use lifelong acquired number of countries. Opinions, not always generated by evidence‐based medicine,...
Goal: This study is aimed at comparing the clinical characteristics and histological types of symptomatic asymptomatic patients with heterotopic gastric mucosa in upper esophagus (HGMUE) exploring factors influencing occurrence severity laryngopharyngeal reflux (LPR) symptoms these patients. Background: HGMUE a potential cause LPR symptoms. Study: retrospective analysis evaluated 70 using detailed questionnaire. Clinical, histological, high-resolution manometry, 24-h pH impedance monitoring...