A5101590179- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Effects of Environmental Stressors on Livestock
- Meat and Animal Product Quality
- Reproductive Physiology in Livestock
- Animal Genetics and Reproduction
- Milk Quality and Mastitis in Dairy Cows
- Heat shock proteins research
- RNA modifications and cancer
- Selenium in Biological Systems
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Infant Nutrition and Health
- Cancer-related gene regulation
- Blockchain Technology Applications and Security
- Peptidase Inhibition and Analysis
- Crop Yield and Soil Fertility
- Growth Hormone and Insulin-like Growth Factors
- Maternal and fetal healthcare
- Renal Diseases and Glomerulopathies
- Sunflower and Safflower Cultivation
- T-cell and B-cell Immunology
Langfang Normal University
2017-2025
Anhui University
2025
Beijing Tian Tan Hospital
2025
Capital Medical University
2016-2025
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Guangdong Academy of Medical Sciences
2020-2024
Guangdong Provincial People's Hospital
2020-2024
Shantou University
2021-2024
Shantou University Medical College
2021-2024
The posttranscriptional gene regulation mediated by microRNA plays an important role in the development and function of male female reproductive organs germ cells mammals, including cattle.In present study, we identified novel differentially expressed miRNAs testis ovary Holstein cattle combining Solexa sequencing with bioinformatics.In total 100 104 pre-miRNAs were testicular ovarian tissues, encoding 122 136 mature miRNAs, respectively.Of these, 6 appear to be bovine-specific.A 246 known...
MicroRNAs (miRNAs) are a class of small noncoding RNAs that play important roles in the regulation gene expression. However, role miRNAs bovine mammary gland responses to heat stress is not well understood. In present study, we performed deep RNA sequencing analysis identify associated with potential gland. We identified 27 were differentially expressed significantly between tissue Holstein cattle and normal conditions. Twenty had higher expression heat-stressed cattle. The seven highest...
Heat-shock transcription factors (HSFs) play an important role in regulating heat stress response. The activation of heat-shock protein (HSP) genes is mediated by HSFs, which bind to promoters HSP genes. In this research, two novel single nucleotide polymorphisms, T909C and G4693T, their association with thermal tolerance were investigated 951 Chinese Holstein cattle. Linkage disequilibrium haplotype construction analyzed using SHEsis software. Four haplotypes constructed, nine combinations...
Major histocompatibility complex, class II, DQ alpha 2, also named BOLA-DQA2, belongs to the Bovine Leukocyte Antigen (BOLA) II genes which are involved in immune response. To explore variability of BOLA-DQA2 gene and resistance mastitis cows, splice variants (SV), targeted microRNAs (miRNAs), single nucleotide polymorphisms (SNPs) were identified this study. A new SV (BOLA-DQA2-SV1) lacking part exon 3 (195 bp) two 3′-untranslated regions (UTR) (52 bp+167 was found healthy mastitis-infected...
Two size of nano-scale (40 nm, 60 nm) and one micro-scale (200 silica particles were studied to investigate the possible mechanism cytotoxicity autophagy dysfunction in human bronchial epithelial BEAS-2B cells.
Heat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is most common internal RNA modification in eukaryotes and plays key role regulating heat response animals. In cows, however, this remains largely unexplored. Therefore, we examined effects of m6A gene expression bovine mammary epithelial cells to elucidate mechanism response. study, Mammary alveolar cells-large T antigen (MAC-T) were incubated at 37 °C (non-heat group, NH) 40 (heat H) for...
Non-small-cell lung cancer (NSCLC) is the leading cause of tumor-related death in humans. Radiotherapy a crucial strategy for NSCLC treatment, although its effectiveness limited by radio-resistance tumor cells. Our current research finds that protein arginine methyltransferase 7 (PRMT7) upregulated and correlates with poor prognosis. Pharmacological inhibition PRMT7 SGC3027, specific small-molecule inhibitor, suppresses proliferation, migration invasion NSCLC. Combining irradiation SGC3027...
ABSTRACT Background Chinese Holstein is a dairy cattle breed developed through crossbreeding and long‐term selection. The Beijing represents distinct population within the breed, specifically bred in region. Objectives This study aimed to estimate genetic parameters for six economic traits cows. Methods Data from 5409 cows across 13 farms were analysed by MTDFREML SAS software. linear univariate bivariate animal model analyses employed heritabilities correlations, respectively. Results...
Mastitis is an important disease limiting milk production in dairy cows. Somatic cell score commonly used as one of the main ways to gauge level mastitis cows, with higher somatic scores usually indicating possible mastitis. However, molecular markers affecting remain unknown. The aim this study was investigate association between single nucleotide polymorphisms SLC11A1 gene and Chinese Holstein In study, 210 cows were genotyped potential SNPs detected by DNA sequencing, PCR-SSCP PCR-RFLP...
The sperm-specific phospholipase C zeta (PLCz) is a candidate sperm-borne oocyte-activating factor that triggers characteristic series of physiological stimuli via cytoplasmic Ca2+ oscillations during fertilization. molecular mechanisms involved in the regulation PLCz gene expression remain largely unknown. To explore genetic variations 5′-flanking region and their common haplotypes Chinese Holstein bulls, as well to determine whether these affect bovine semen quality traits transcriptional...
The mechanisms that dairy cattle respond to environmental stresses are very complicated. Previous research into the molecular of mammalian heat stress has largely focused on role protein-coding genes and small non–coding RNAs. Recently, it become apparent large numbers long non-coding RNAs transcribed from genomes play extensive roles in transcriptional regulation. However, expression lncRNAs their biological functions remain unknown. In this study, we employed a deep RNA sequencing examine...
Summary HMGB 3 (high‐mobility group box 3) is an X ‐linked member of a family sequence‐independent chromatin‐binding proteins and functions as universal sentinel for nucleic acid–mediated innate immune responses. The splice variant expression, promoter characterization targeted micro RNA s the bovine gene were investigated to explore its expression pattern possible regulatory mechanism. results revealed that transcript variants 1 2 ( 3‐ TV ‐ 2) mRNA in mastitis‐infected mammary gland tissues...