A5110581821- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Vascular Anomalies and Treatments
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Macrophage Migration Inhibitory Factor
- Cardiac Valve Diseases and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Eicosanoids and Hypertension Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Heart Failure Treatment and Management
- Biochemical Analysis and Sensing Techniques
- Transplantation: Methods and Outcomes
- Regulation of Appetite and Obesity
- Pancreatitis Pathology and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Cardiovascular Conditions and Treatments
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Wuyi University
2022-2024
First Hospital of Xi'an
2017-2022
Baker Heart and Diabetes Institute
2012-2019
The Alfred Hospital
2014-2017
Xi'an Jiaotong University
2009-2016
Peking University
2008-2011
Ministry of Education of the People's Republic of China
2009
Endothelin receptor antagonist (ERA) and phosphodiesterase 5 inhibitor (PDE5i) combination therapy is recommended for low-/intermediate-risk pulmonary arterial hypertension (PAH) patients. A fixed-dose of the ERA macitentan PDE5i tadalafil (M/T FDC) in a once-daily, single tablet would simplify treatment. The multicenter, double-blind, adaptive phase 3 DUE study investigated efficacy safety M/T FDC vs 10 mg 40 monotherapies PAH patients, including treatment-naïve prior or monotherapy-treated...
Atherosclerosis and its complications rank as the leading cause of death with hallmarks lipid deposition inflammatory response. MicroRNAs (miRNAs) have recently garnered increasing interests in cardiovascular disease. In this study, we investigated function miR-223 underlying mechanism atherosclerosis. atherosclerotic ApoE-/- mice models, an obvious increase was observed aortic lesions. lipopolysaccharide (LPS) activated macrophages, expression decreased. The overexpression significantly...
World Health Organization (WHO) group 1 pulmonary arterial hypertension (PAH) is a progressive, debilitating disease. Previous observational studies have demonstrated that artery denervation (PADN) reduces pressures in PAH. However, the safety and effectiveness of PADN not been established randomized trial. The aim this study was to determine treatment effects patients with Patients WHO PAH taking PAH-specific drugs for at least 30 days were enrolled multicenter, sham-controlled,...
Early diagnosis and knowledge of infarct size is critical for the management acute myocardial infarction (MI). We evaluated whether early elevated plasma level macrophage migration inhibitory factor (MIF) useful these purposes in patients with ST-elevation MI (STEMI).We first studied MIF myocardium mice determined size. 15 or 60 minutes resulted 2.5-fold increase over control values levels while content ischemic reduced by 50% correlated myocardium-at-risk at both time-points (P < 0.01). In...
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis (UC) and Crohn's (CD), is believed to be caused by abnormal host immune responses the intestinal microbiome. However, precise etiology of IBD remains unknown. Lipid metabolism signaling are suggested play important roles in inflammation with significant implications for IBD. In this study, we aimed characterize lipidomic profiles comparison between healthy controls, UC, CD. Patients (n = 40, UC: 16 CD: 24) age-...
Article23 April 2020Open Access Source DataTransparent process MicroRNA-483 amelioration of experimental pulmonary hypertension Jin Zhang Cardiovascular Research Center, School Basic Medical Sciences, Xi'an Jiaotong University Health Science Key Laboratory Environment and Genes Related to Diseases, Ministry Education China, University, Xian, China Search for more papers by this author Yangyang He State disease & FuWai Hospital, Chinese Academy Sciences Peking Union College, Beijing, Xiaosong...
Inflammation plays an important role in the pathogenesis of atherosclerosis. The link between rheumatoid arthritis (RA) and increased risk cardiovascular disease mortality is well established; however, association inflammatory bowel (IBD) controversial. Arterial stiffness both a marker factor for Here we aimed to 1) compare circulating markers inflammation endothelial dysfunction, traditional factors, arterial RA IBD help understand their different associations with disease; 2) assess...
This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu's arteritis-associated pulmonary hypertension (TA-PH).We conducted a nationally representative cohort of TA-PH using data from National Rare Diseases Registry System China. Patients artery involvement who fulfilled diagnostic criteria arteritis were included. The primary was time diagnosis occurrence all-cause death. Between January 2007 2019, total 140 included, mean age 41.4...
Aim: Patients with congenital heart disease-related pulmonary arterial hypertension (CHD-PAH) often require regular follow-up through invasive right catheterization (RHC) to assess disease progression and potential interventions. This study aims evaluate the relationship between arteriovenous oxygen content difference (Ca&minus;vO2) RHC parameters identify blood gas that can aid in a clue about pre-selecting patients CHD-PAH for surgical or percutaneous shunt closure. Methods: In this...
This study explored patient and clinician perspectives on a new fixed-dose combination of macitentan tadalafil (M/T FDC) in once-daily single tablet for treatment pulmonary arterial hypertension (PAH). Qualitative semi-structured interviews were conducted during the open-label period global, phase 3 A DUE clinical trial that evaluated M/T FDC. subset enrolled patients (N = 26) site investigators 18 clinicians) interviewed. Patients received four tablets double-blind could be one three arms...
To determine the relationship between maternal anxiety and cortisol values birth weight at various stages of pregnancy. Two hundred sixteen pregnant Chinese women were assessed for depression had measurement morning fasting serum cortisol. Women either in first (71), second (72) or third (73) trimester. Birth weights all children recorded. There significant negative correlations level − 0.507 (p < 0.01) 0.275 0.05) trimesters 1and 2. In trimester 3 relation −.209 failed to reach significance...
Myocardial fibrosis (MF) is one of the basic causes many cardiovascular diseases. Noncoding RNAs (ncRNAs), including microRNA (miRNA) and long noncoding RNA (lncRNA), have been reported to play an indispensable role in MF. The current work focused on investigating biological lncRNA taurine upregulation gene 1 (TUG1) activating cardiac myofibroblasts as well underlying mechanism. outcome revealed that after myocardial infarction TUG1 expression increased miR-133b decreased rat model level...
Monoclonal antibodies are at the vanguard of most promising cancer treatments. Whereas traditional therapeutic have been limited to extracellular antigens, T cell receptor mimic (TCRm) can target intracellular antigens presented by surface major histocompatibility complex (MHC) proteins. TCRm therefore a repertoire otherwise undruggable antigens. However, consequences off-target peptide/MHC recognition with engineered therapies severe, and thus there significant safety concerns antibodies....
Restenosis after angioplasty remains a major clinical problem. Prostaglandin E(2) (PGE(2)) plays an important role in vascular homeostasis. The PGE(2) receptor E-prostanoid 2 (EP2) is involved the proliferation and migration of various cell types. We aimed to determine EP2 pathogenesis neointimal formation injury.Wire-mediated injury was induced femoral arteries male wild-type (EP2+/+) gene-deficient (EP2-/-) mice. In EP2+/+ mice, mRNA expression increased injured vessels for at least 4...
Decreased pulmonary artery smooth muscle cell (PASMC) apoptosis play a key role in remodeling during hypertension (PAH), but the mechanisms involved are unclear. Serotonin (5-HT) inhibits many pathologic processes by activating 5-HT2A receptor. Therefore, we hypothesized that 5-HT may be promoter of decreased PAH through We found inhibition receptor prevented increase pressure and rats stimulated monocrotaline. This effect was accompanied increased artery. Cultured PASMCs with showed...
It has been shown that activation of Notch3 signaling is involved in the development pulmonary arterial hypertension (PAH) by stimulating arteries remodeling, while molecular mechanisms underlying this are still largely unknown. The aims study to address these issues. Monocrotaline dramatically increased right ventricle systolic pressure 39.0 ± 2.6 mmHg and hypertrophy index 53.4 5.3% (P < 0.05 versus control) rats, were accompanied with significantly proliferation reduced apoptosis vascular...
Macrophage migration inhibitory factor (MIF) is a key regulator of inflammatory responses, including in the heart. Plasma MIF elevated early course acute myocardial infarction. In this study, we hypothesized that plasma may also be increased ischemia.Patients undergoing cardiac stress test (stress nuclear perfusion scan or echocardiography) were recruited. Twenty-two patients had indicative ischemia and compared with 62 who negative test. was measured by ELISA before after peripheral...