A5106484729- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Macrophage Migration Inhibitory Factor
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Cardiovascular Effects of Exercise
- Pregnancy-related medical research
- Cardiac Structural Anomalies and Repair
- S100 Proteins and Annexins
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Signaling Pathways in Disease
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects and Assays
- Occupational Health and Performance
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Cardiovascular Issues in Pregnancy
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myocardial Infarction Research
- Galectins and Cancer Biology
- Heart Rate Variability and Autonomic Control
- Ultrasound and Hyperthermia Applications
Xi'an Jiaotong University
2023
Baker Heart and Diabetes Institute
2012-2021
Xinjiang Medical University
2007-2021
First Affiliated Hospital of Xinjiang Medical University
2015-2020
Monash University
2011-2019
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2019
Institute of Experimental Cardiology
2015
The University of Melbourne
2010-2012
New York University
2012
Australian National University
2010
Objective— Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. Activation phosphoinositide 3-kinase [PI3K(p110α)] considered new strategy for the treatment However, whether PI3K(p110α) provides protection in setting MI unknown, and difficult target because it has multiple actions numerous cell types. The goal this study was assess beneficial and, if so, identify cardiac-selective microRNA mRNA that...
Background— Numerous molecular and biochemical changes have been linked with the cardioprotective effects of exercise, including increases in antioxidant enzymes, heat shock proteins, regulators cardiac myocyte proliferation. However, a master regulator exercise-induced protection has yet to be identified. Here, we assess whether phosphoinositide 3-kinase (PI3K) p110α is essential for mediating cardioprotection, if so, its activation independent exercise can restore function failing heart....
Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct targets remain poorly characterized. Since inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized acetylation would target genes implicated in remodeling. Trichostatin A (TSA) regulates expression attenuates transverse aortic constriction (TAC) induced hypertrophy. We used chromatin immunoprecipitation (ChIP)...
Expression of microRNA-652 (miR-652) increases in the diseased heart, decreases a setting cardioprotection, and is inversely correlated with heart function. The aim this study was to assess therapeutic potential inhibiting miR-652 mouse model established pathological hypertrophy cardiac dysfunction due pressure overload. Mice were subjected sham operation or transverse aortic constriction (TAC) for 4 wk induce dysfunction, followed by administration locked nucleic acid (LNA)-antimiR-652...
Therapeutic inhibition of the miR-34 family (miR-34a,-b,-c), or miR-34a alone, have emerged as promising strategies for treatment cardiac pathology. However, before advancing these approaches further potential entry into clinic, a more comprehensive assessment therapeutic inhibiting is required two key reasons. First, has ∼40% fewer predicted targets than family. Hence, in stress settings which provides adequate protection, this approach likely to result less off-target effects. Secondly,...
The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, effects of on cardiomyocytes (CM) remain determined. We investigated isoform 2 human (H2-relaxin) CM hypertrophy and apoptosis. In cultured neonatal rat CM, phenylephrine (50 μm) cardiac fibroblast-conditioned medium were used respectively induce hypertrophy. degree was indicated by increased cell size, protein synthesis gene expression atrial...
ObjectivesMacrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, has been implicated in the pathogenesis of multiple inflammatory disorders. We determined changes circulating MIF levels, explored cellular source MIF, and studied role mediating responses following acute myocardial infarction (MI). Methods ResultsWe recruited 15 patients with MI, 10 stable angina healthy volunteers measured temporal plasma. Expression matrix metalloproteinase-9 (MMP-9) interleukin-6 (IL-6)...
Early diagnosis and knowledge of infarct size is critical for the management acute myocardial infarction (MI). We evaluated whether early elevated plasma level macrophage migration inhibitory factor (MIF) useful these purposes in patients with ST-elevation MI (STEMI).We first studied MIF myocardium mice determined size. 15 or 60 minutes resulted 2.5-fold increase over control values levels while content ischemic reduced by 50% correlated myocardium-at-risk at both time-points (P < 0.01). In...
Background The prevalence and risk factors of congenital heart disease among Xinjiang, northwestern part China is currently unknown. Methods This multiple-ethnic, community-based, cross-sectional study was conducted to estimate the distribution (CHD) in China. Four major ethnics, Uygur, Han, Kazak, Hui children this region were investigated during February 2010 May 2012. Results A total 14,530 (0–18 yr) examined. Of these children, 240 (boys, 43.8%, girls, 56.3%) identified with CHD, giving...
Abstract Expression of miR-154 is upregulated in the diseased heart and was previously shown to be lungs patients with pulmonary fibrosis. However, role a model sustained pressure overload-induced cardiac hypertrophy fibrosis had not been assessed. To examine heart, adult male mice were subjected transverse aortic constriction for four weeks echocardiography performed confirm left ventricular dysfunction. Mice then subcutaneously administered locked nucleic acid antimiR-154 or control over...
Adeno-associated virus (AAV) has become one of the most promising gene transfer tools for therapy. This work aims to evaluate tropism, efficiency and safety AAV9 vectors produced with recombinant baculovirus (rBac)-based system. AAV9-CMV-GFP AAV9-CBA-GFP were using a rBac system, 1 × 10(11) particles each administered intravenously (i.v.) into mice animals killed at 1, 2, 3, 4, 5 8 weeks after administration. The GFP expression in different organs was analyzed by fluorescence imaging Western...
One of the major hurdles in intravenous regenerative cell therapy is low homing efficiency to area where these cells are needed. To increase toward areas myocardial damage, we developed a bispecific tandem single-chain antibody (Tand-scFvSca-1+GPIIb/IIIa) that binds with high affinity activated platelets via glycoprotein (GP)IIb/IIIa receptor, and subset peripheral blood mononuclear (PBMC) which express stem antigen-1 (Sca-1) receptor. Methods: The Tand-scFvSca-1+GPIIb/IIIa was engineered,...
Myocardial fibrosis is regarded as a pivotal proarrhythmic substrate, but there have been no comprehensive studies showing correlation between the severity of and ventricular tachyarrhythmias (VTAs). Our purpose was to document this relationship in transgenic (TG) strain mice with fibrotic cardiomyopathy. TG cardiac overexpression β 2 -adrenoceptors (β -AR mice) non-TG (NTG) littermates were studied at 4–12 mo age. VTA quantified by ECG telemetry. The effect pharmacological blockade -ARs on...
Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and function after ischaemic insults vitro, but its long-term cardioprotective actions vivo are largely unknown. We tested the hypothesis that ANX-A1-deficiency exaggerates inflammation, haematopoietic stem progenitor cell (HSPC) activity LV remodelling response to myocardial ischaemia vivo. Adult ANX - A1 -/- mice subjected coronary artery occlusion exhibited increased...
Type A acute aortic dissection is a life-threatening vascular emergency because of its high morbidity and mortality. Platelet pivotal ingredient involved in the development dissection. In this study, we aimed to investigate whether mean platelet volume (MPV)/platelet count ratio predicts in-hospital complications long-term mortality type single-center prospective cohort 106 consecutive patients with Stanford admitted hospital within 12 h after onset were recruited. The best cut-off value...
Objectives Little is known about isolated diastolic hypertension (IDH) among different ethnicity groups. We aimed to investigate the prevalence and risk factors for IDH major population i.e. Han, Uygur Kazakh in Xinjiang, northwestern part of China. Methods In total, 14,618 adult participants (7,799 males, 6,819 females) were recruited from Cardiovascular Risk Survey conducted during 2007 2010. Blood pressure, body mass index standard lipid profile fasting glucose level plasma measured....
Oxidative stress injury is one of the main mechanisms ischemia-reperfusion (I/R) injury. The extracellular signal-regulated kinase (ERK1/2) pathway plays an important role in cardioprotective during acute myocardial infarction. In this study, we used constitutively active MEK1 gene (CaMEK) transfection strategy to investigate whether CaMEK provides a protective effect against apoptosis and autophagy induced by Hydrogen peroxide (H2O2) neonatal rat cardiac ventricular cardiomyocytes (NCMs)...
Ischemic preconditioning (IPC) is an endogenous protection strategy against myocardial ischemia-reperfusion (I/R) injury. Macrophage migration inhibitory factor (MIF) released from the myocardium subjected to brief periods of ischemia confers cardioprotection. We hypothesized that MIF plays essential role in IPC-induced I/R was induced either ex vivo or male wild-type (WT) and knockout (MIFKO) mice with without proceeding IPC (three cycles 5-min reperfusion). Indices injury, regional...
The effect of endogenous relaxin on the development cardiac hypertrophy, dysfunction, and fibrosis remains completely unknown. We addressed this question by subjecting relaxin-1 deficient (Rln1−/−) littermate control (Rln1+/+) mice both genders to chronic transverse aortic constriction (TAC). extent left ventricular (LV) remodeling dysfunction were studied serial echocardiography over an 8-wk period micromanometry. degree hypertrophy was estimated LV weight, cardiomyocyte size, expression...
BACKGROUND AND PURPOSE Darbepoetin, a long‐acting erythropoietin derivative, attenuates cardiomyocyte apoptosis and improves short‐term (3 days) cardiac function, but the mechanisms responsible are unknown. We investigated potential by which darbepoetin exerts cardioprotection following myocardial infarction in mice significance of receptor (EPOR)–common β‐chain (c‐β‐chain) heteroreceptor. EXPERIMENTAL APPROACH Mice underwent 60 min coronary occlusion followed treatment with vehicle or...