A5044910332- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Mesenchymal stem cell research
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Arrhythmias and Treatments
- Synthetic Organic Chemistry Methods
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Fuel Cells and Related Materials
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Advanced Synthetic Organic Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Inflammation biomarkers and pathways
- Carbohydrate Chemistry and Synthesis
- PARP inhibition in cancer therapy
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Xi'an Jiaotong University
2014-2024
Queen's University
2011-2024
Ninth Hospital of Nanchang
2024
Shaanxi Provincial People's Hospital
2022
Fourth Affiliated Hospital of China Medical University
2016-2022
Kingston Health Sciences Centre
2013-2019
MSIGHT Technologies (China)
2017
State Key Laboratory of Oncogene and Related Genes
2017
China Medical University
2016
Heart failure (HF) is the end-stage of cardiovascular diseases, which associated with a high mortality rate and readmission rate. Household early diagnosis real-time prognosis HF at bedside are significant importance. Here, we developed highly sensitive quantitative household platform (termed as UC-LFS platform), integrating smartphone-based reader multiplexed upconversion fluorescent lateral flow strip (LFS). Dual-color core–shell nanoparticles (UCNPs) were synthesized probes for...
Abstract Neutrophil extracellular traps (NETs) which have a potential role in noninfectious diseases, may play an important patients with acute coronary syndrome. The goal of this study was to investigate the association NETs and in-hospital major adverse cardiac events among ST-segment elevation myocardial infarction (STEMI). Using immunofluorescence staining, ELISA, fluorescent enzyme standard instrument, we assessed NETs-related factors. Multivariate analyses were performed after...
Reductions in voltage-gated sodium channel (Nav1.5) function/expression provide a slowed-conduction substrate for cardiac arrhythmias. Nedd4-2, which is activated by calcium, post-translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca2+ ]i ) reduces Nav1.5 through Nedd4-2 and its role heart failure (HF).Using combination of biochemical, electrophysiological, cellular vivo methods, we tested the effect mechanism on turn Nav1.5.Increased [Ca2+ ,...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to arrhythmia due altered Ca(2+) homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established that homozygotic murine RyR2-P2328S (RyR2 (S/S)) hearts show an atrial arrhythmic phenotype associated with reduced action potential (AP) conduction velocity sodium channel (Nav1.5) expression. We now relate arrhythmogenicity slowed AP in RyR2 (S/S) connexin-43 (Cx43)...
Background Metabolic disorders are the most important risk factors for cardiovascular diseases (CVDs). The purpose of this study was to systematically analyze and summarize recent data by age, sex, region, time, forecast future burden diseases. Methods Data on CVDs associated with metabolic were obtained from Global Burden Disease (GBD) Study 2019; then disease assessed using numbers age-standardized rates (ASR) deaths, years life lost (YLLs), lived disability (YLDs), disability-adjusted...
Cardiac repolarization is controlled by the rapidly (I<sub>Kr</sub>) and slowly (I<sub>Ks</sub>) activating delayed rectifier potassium channels. The human ether-a-go-go-related gene (<i>hERG</i>) encodes I<sub>Kr</sub>, whereas KCNQ1 KCNE1 together encode I<sub>Ks</sub>. Decreases in I<sub>Kr</sub> or I<sub>Ks</sub> cause long QT syndrome (LQTS), a cardiac disorder with high risk of sudden death. A reduction extracellular K<sup>+</sup> concentration ([K<sup>+</sup>]<i><sub>o</sub></i>)...
As the most prevalent and lethal type of brain tumours, gliomas, especially malignant ones, are relatively resistant to conventional therapies. Gremlin 1 (GREM1) is a secreted glycoprotein that implicated in maintenance cancer stem cells tumour hierarchy. In current study, role GREM1 carcinogenesis glioma was studied using knockdown approach. We first examined expression level clinical samples, then evaluated effect on viability colony formation capacity U87-MG cells. Moreover, migration...
Clinical indicators do not adequately predict the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). The low-density lipoprotein (LDL)/high-density (HDL) ratio is expected to be a reliable predictor these patients. This study aimed explore correlation between LDL/HDL and in STEMI undergoing PCI. Patients confirmed who underwent PCI 7 hospitals China from January 2009 December 2011 were enrolled....
An enantioselective route to the marine toxin (+)-acetoxycrenulide is described. The early stages of synthesis feature conversion (R)-citronellol into a butenolide whose sole stereogenic center provided by terpenic alcohol. Three contiguous chiral carbon atoms are subsequently set in requisite absolute configuration conjugate addition an enantiopure allylphosphonamide reagent. resulting product transformed during several steps primary selenoxide thermal activation dimethylacetamide at 220 °C...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of the Cembranoid Diterpene Lactone (+)-Cleomeolide. Some Remarkable Conformational Features Nine-Membered Belts Linked in 2,6-Fashion to a Methylenecyclohexane CoreLeo A. Paquette, Ting-Zhong Wang, Christophe M. G. Philippo, and Shaopeng WangCite this: J. Am. Chem. Soc. 1994, 116, 8, 3367–3374Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April...