A5023591621- Cardiac electrophysiology and arrhythmias
- Liver Disease Diagnosis and Treatment
- Ion channel regulation and function
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Hepatitis B Virus Studies
- Retinal Imaging and Analysis
- Metabolism, Diabetes, and Cancer
- Cardiac Arrest and Resuscitation
- Diabetes Treatment and Management
- Glaucoma and retinal disorders
- Folate and B Vitamins Research
- Retinal and Optic Conditions
- Heart Failure Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Arrhythmias and Treatments
- Retinal Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Thermal Analysis in Power Transmission
- Esophageal Cancer Research and Treatment
- Cardiovascular Issues in Pregnancy
- Thallium and Germanium Studies
- HIV/AIDS drug development and treatment
Capital Medical University
2004-2025
Peking University
2013-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Sun Yat-sen University
2022-2025
Rush University
2025
Beijing Jishuitan Hospital
2013-2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
First Affiliated Hospital of Xi'an Jiaotong University
2015-2020
Beijing Anzhen Hospital
2020
Background: Previous studies have verified that metabolic dysfunction-associated steatotic liver disease (MASLD) confered higher risk of coronary atherosclerosis development. However, whether MASLD influence prognosis after drug-eluting stent (DES) implantation treatment remain not known. Methods: In this retrospective observational study, 301 included cardiovascular (CVD) patients who underwent re-coronary angiography the first successful DES-based percutaneous intervention. All received...
Whether the weight-loss plateau and its values differ in obesity with or without metabolic dysfunction-associated steatotic liver disease (MASLD) undergoing continuous lifestyle intervention remains unknown. We aimed to investigate this problem. This prospective observational cohort study included 305 patients MASLD 103 matched individuals non-MASLD from January 2015 April 2023, a 12-month follow-up monitor weight changes. Liver biochemistry, fat content MRI-PDFF, stiffness measurement via...
Background: Bedside ultrasound is widely utilized for critically ill patients, yet there no standardized approach teaching lung to medical staff, particularly respiratory therapists (RTs), in the United States. Thus, we aimed evaluate efficacy of a training program designed RTs. Methods: With approval from ethics committee, recruited RTs with over 3 months experience at Rush University Medical Center participate our program. The comprised 1-h didactic lecture followed by hands-on practice on...
Reductions in voltage-gated sodium channel (Nav1.5) function/expression provide a slowed-conduction substrate for cardiac arrhythmias. Nedd4-2, which is activated by calcium, post-translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca2+ ]i ) reduces Nav1.5 through Nedd4-2 and its role heart failure (HF).Using combination of biochemical, electrophysiological, cellular vivo methods, we tested the effect mechanism on turn Nav1.5.Increased [Ca2+ ,...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to arrhythmia due altered Ca(2+) homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established that homozygotic murine RyR2-P2328S (RyR2 (S/S)) hearts show an atrial arrhythmic phenotype associated with reduced action potential (AP) conduction velocity sodium channel (Nav1.5) expression. We now relate arrhythmogenicity slowed AP in RyR2 (S/S) connexin-43 (Cx43)...
Ultrasound is a convenient tool to evaluate cardiac and diaphragm function. The ratio (E/Ea) of mitral Doppler inflow velocity annular tissue wave by transthoracic echocardiography (TTE) diaphragmatic excursion (DE) ultrasound have been confirmed in predicting extubation outcomes independently, however their different roles the weaning process not determined until now. We designed cohort study preform TTE before after spontaneous breathing trial (SBT) difficult-to-wean patients. Patients...
Abstract Aims Pathogenic variants of the SCN5A gene can cause Brugada syndrome (BrS) and long QT (LQTS), which predispose individuals to potentially fatal ventricular arrhythmias sudden cardiac death. encodes Na V 1.5 protein, pore forming α‐subunit voltage‐dependent + channel. Using a WW domain, E3 ubiquitin ligase Nedd4‐2 binds PY‐motif ([L/P]PxY) within C‐terminus 1.5, results in decreased protein expression current through ubiquitination. Here, we investigate role Nedd4‐2‐mediated...
The health influence of air pollution has been an international public concern. Increasing evidence suggested that associated with decreased sperm quality. However, the underlying molecular mechanisms are still not fully elucidated. We aimed to verify whether gasoline exhaust leads reproductive impairment by injuring spermatogonial stem cells and explore its mechanism. Twenty male Sprague-Dawley rats were randomly divided into two groups: exposure group (n = 10) control 10). After 6-month...
Abstract Aims Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while longitudinal data are scarce. We aimed to explore impact changes in relative on MAFLD treatment response. Methods patients undergoing magnetic resonance imaging-based proton density fat fraction for content (LFC) assessments and bioelectrical impedance analysis before after (orlistat, meal replacement, lifestyle modifications) were...
Clenbuterol, a β2-selective adrenergic receptor agonist, is illicitly used in weight loss and performance enhancement animal production. Increasing evidence demonstrates that clenbuterol induces various kinds of arrhythmias QTc interval prolongation. However, little known about the underlying mechanism. Most drugs are associated with prolongation through interfering human ether-a-go-go-related gene (hERG) K + channels. The present study aims to investigate effects mechanisms on hERG channel....
To explore the relationship between Helicobacter pylori (H.pylori) infection and gastric mucosa change blood-lipid in people undergoing physical examination Changsha.A total of 2 264 were divided into an H. pyloripositive group (n=1 068) pylori-negative 196). Gastric was diagnosed by gastroscopy, blood sugar detected, statistical analysis performed.The incidence rate H.pylori 47.2%. The mucosal erosion, ulcer, duodenal atrophy, polyp, dyslipidemia, increase triglyceride (TG) decrease high...
Abstract Background The ratio (E/Ea) of mitral Doppler inflow velocity to annular tissue wave by transthoracic echocardiography and diaphragmatic excursion (DE) diaphragm ultrasound have been confirmed predict extubation outcomes. However, few studies focused on the predicting value E/Ea DE at different positions during a spontaneous breathing trial (SBT), as well effects △E/Ea △DE (changes in SBT). Methods This study was reanalysis data 60 difficult-to-wean patients previous published 2017....
To the Editor: Tuberculosis (TB) is leading cause of death in people living with HIV (PLWH) globally. Given increased risk TB infection, preventive therapy (TPT) recommended for PLWH to prevent activation and reduce relevant mortality. However, implementation TPT remains weak only 21% eligible initiated on globally 2021,[1] primarily due challenges developing countries. The low completion rate may be attributed various reasons, including socio-economic factors, individual behaviors...
<title>Abstract</title> Background Successful antiviral therapy significantly decreases the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Alpha-fetoprotein (AFP) serum is a valuable early indicator HCC. However, it unclear whether different medications have varying effects on AFP levels. The purpose this study was to evaluate issue those treated entecavir (ETV) versus tenofovir disoproxil fumarate (TDF). Methods We prospectively enrolled...