A5074565083- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Neuroscience and Neural Engineering
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Veterinary Practice and Education Studies
- Receptor Mechanisms and Signaling
- Heart Rate Variability and Autonomic Control
- Innovations in Medical Education
- Neuroscience and Neuropharmacology Research
- Cardiomyopathy and Myosin Studies
- Problem and Project Based Learning
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diversity and Career in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Medical Education and Admissions
- Health and Medical Research Impacts
- Diverse Educational Innovations Studies
- Social Media in Health Education
- Fuel Cells and Related Materials
University of Surrey
2016-2025
Leverhulme Trust
2024
Medway School of Pharmacy
2023
Kent and Medway Medical School
2023
Physiological Society
2010-2022
University of Cambridge
2010-2022
Perdana University
2012-2019
Royal College of Surgeons in Ireland
2012-2019
Royal College of Surgeons of England
2019
International Medical University
2010
Understanding the rules of life is one most important scientific endeavours and has revolutionised both biology biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range complex dynamic biological processes which living systems could exploit quantum behaviour enhance regulate functions. Recent evidence suggests that these non-trivial mechanical effects may play crucial role maintaining non-equilibrium state biomolecular systems. Quantum study such...
To compare the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2Is) and dipeptidyl peptidase-4 (DPP4Is) on adverse outcomes in diabetic patients Hong Kong.This was a retrospective population-based cohort study type diabetes mellitus (n = 72,746) treated with SGLT2I or DPP4I between January 1, 2015, December 31, 2020, Kong. Patients exposure to both therapy, without complete demographics mortality data, who had prior atrial fibrillation (AF) were excluded. The new-onset AF,...
Objectives Brugada syndrome (BrS) is an ion channelopathy that predisposes affected patients to spontaneous ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death. The aim of this study examine the predictive factors VT/VF. Methods This was a territory-wide retrospective cohort diagnosed with BrS between 1997 2019. primary outcome Cox regression used identify significant risk predictors. Non-linear interactions variables (latent patterns) were extracted using non-negative...
Objectives Feline infectious peritonitis (FIP) is a serious disease that arises due to feline coronavirus infection. The nucleoside analogues remdesivir and GS-441524 can be effective in its treatment, but most studies have used unregulated products of unknown composition. aim the present study was describe treatment FIP using legally sourced veterinary-prescribed regulated veterinary compounded containing known amounts (injectable) or (oral tablets). Methods Cats were recruited via email...
The present study evaluated the application of incorporating non-linear J/U-shaped relationships between mean HbA1c and cholesterol levels into risk scores for predicting acute myocardial infarction (AMI) non-AMI-related sudden cardiac death (SCD) respectively, amongst patients with type 2 diabetes mellitus.This was a territory-wide cohort mellitus above age 40 free from prior AMI SCD, or without prescriptions anti-diabetic agents January 1st, 2009 to December 31st, at government-funded...
Congenital long QT syndrome (LQTS) is a cardiac ion channelopathy that predisposes affected individuals to spontaneous ventricular tachycardia/fibrillation (VT/VF) and sudden death (SCD). The main aims of the study were to: (1) provide description local epidemiology LQTS, (2) identify significant risk factors arrhythmias in this cohort, (3) compare performance traditional Cox regression with random survival forests.
Abstract Aims Frailty may be found in heart failure patients especially the elderly and is associated with a poor prognosis. However, assessment of frailty status time‐consuming, electronic indices developed using health records have served as useful surrogates. We hypothesized that an index machine learning can improve short‐term mortality prediction failure. Methods results This was retrospective observational study included admitted to nine public hospitals for from Hong Kong between 2013...
Abstract Cardiac dysautonomia plays an important role in understanding Parkinson's disease (PD), with recent studies highlighting the presence of α‐synuclein cardiac tissue. We hypothesise that sympathetic dysregulation observed PD may involve pathological changes caused by stellate ganglia (SG). This study aimed to investigate α‐synucleinopathy SG genetic murine animal model. Mice overexpressing Ala30Pro (A30P) mutant were used. here demonstrate a technique for meticulously dissecting SG....
Abstract Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose myocardial conducting system arrhythmias. However, little is known about age‐related changes in electrophysiology of murine SG. We investigated alterations electrophysiological properties SG with aging. The loose patch clamp technique was adapted tissue investigate voltage‐gated ionic currents its neuronal cells. compared ventricular cells from young (4 months) aged (13 C57BL/6J mice explore their...
Recent studies reported slowed conduction velocity (CV) in murine hearts homozygous for the gain-of-function RyR2-P2328S mutation (RyR2S/S) and associated this with an increased incidence of atrial ventricular arrhythmias. The present experiments determined mechanisms contributing to reduced CV. determinants CV were investigated RyR2S/S compared those wild-type (WT) slow-conducting Scn5a+/− hearts. Picrosirius red staining demonstrated fibrosis only Immunoblot assays showed similar...
Introduction Patients with diabetes mellitus are risk of premature death. In this study, we developed a machine learning-driven predictive model for all-cause mortality among patients type 2 using multiparametric approach data from different domains. Research design and methods This study used territory-wide attending public hospitals or their associated ambulatory/outpatient facilities in Hong Kong between January 1, 2009 December 31, 2009. The primary outcome is mortality. association...
Metabolic abnormalities may exacerbate the risk of adverse outcomes in patients with type 2 diabetes mellitus. The present study aims to assess predictive value HbA1c and lipid variability on risks sudden cardiac death (SCD) incident atrial fibrillation (AF).The retrospective observational consists diabetic prescribed insulin, who went publicly funded clinics hospitals Hong Kong between January 1, 2009 December 31, 2009. Variability total cholesterol, low-density lipoprotein-cholesterol...
Conduction Changes in RyR2‐P2328S Hearts . Introduction: The familial condition catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic bidirectional (BVT), (PVT), and fibrillation following adrenergic challenge. It associated with mutations involving the cardiac ryanodine receptor ( RyR2 ). Methods Results: We explored for a slowing of myocardial conduction that could potentially result substrate spontaneous arrhythmogenesis was observed introduction...