A5039839674- Ion channel regulation and function
- Lipid Membrane Structure and Behavior
- Osteoarthritis Treatment and Mechanisms
- Protein Structure and Dynamics
- Ion Channels and Receptors
- Anesthesia and Pain Management
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Nuclear reactor physics and engineering
- Nuclear and radioactivity studies
- Radioactive contamination and transfer
- Neuroscience and Neuropharmacology Research
- Nuclear Physics and Applications
- Anesthesia and Sedative Agents
- Microfluidic and Bio-sensing Technologies
- Bone Tissue Engineering Materials
- Spectroscopy and Quantum Chemical Studies
- Particle accelerators and beam dynamics
- Hemodynamic Monitoring and Therapy
- Healthcare and Venom Research
- Surfactants and Colloidal Systems
- 3D Printing in Biomedical Research
- Lipid metabolism and biosynthesis
- thermodynamics and calorimetric analyses
- Ion Transport and Channel Regulation
University of Surrey
2016-2025
Leverhulme Trust
2024
Guildford Hospital
2017
University of North Carolina at Charlotte
2017
Gaston Memorial Hospital
2017
East Carolina University
2017
Sigma Theta Tau International
2017
Savannah River National Laboratory
2016
Gordon Center for Medical Imaging
2015
Massachusetts General Hospital
2013-2015
Understanding the rules of life is one most important scientific endeavours and has revolutionised both biology biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range complex dynamic biological processes which living systems could exploit quantum behaviour enhance regulate functions. Recent evidence suggests that these non-trivial mechanical effects may play crucial role maintaining non-equilibrium state biomolecular systems. Quantum study such...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermotropic phase behavior of model membranes composed phosphatidylcholines containing cis-monounsaturated acyl chain homologs oleic acid: differential scanning calorimetric and phosphorus-31 NMR spectroscopic studiesRuthven N. A. H. Lewis, Brian D. Sykes, Ronald McElhaneyCite this: Biochemistry 1988, 27, 3, 880–887Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February...
Chondrocytes are the resident cells of articular cartilage and responsible for synthesising a range collagenous non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in tissue (1-10% total volume mature cartilage) they extremely active capable responding to mechanical biochemical stimuli. These responses necessary maintenance viable may be compromised inflammatory diseases such as arthritis. Although non-excitable their plasma membrane contains rich...
Abstract Many cell types have significant negative resting membrane potentials (RMPs) resulting from the activity of potassium‐selective and chloride‐selective ion channels. In excitable cells, such as neurones, rapid changes in permeability underlie generation action potentials. Chondrocytes less RMPs role RMP is not clear. Here we examine basis chondrocyte possible physiological benefits. We demonstrate that maintenance involves gadolinium‐sensitive cation Pharmacological inhibition these...
Polarized attenuated total internal reflectance techniques were applied to study the infrared dichroism of amide I transition moment in two membrane-bound peptides that are known form oriented transmembrane helices: gramicidin A a supported phospholipid monolayer and Ac-Lys2-Leu24-Lys2-amide (L24) multibilayers. These studies performed test ability these determine orientation peptides, verify value optical parameters used calculate electric field strengths, examine common assumptions...
Abstract Chondrocytes possess the capacity to transduce load‐induced mechanical stimuli into electrochemical signals. The aim of this study was functionally characterize an ion channel activated in response membrane stretch isolated primary equine chondrocytes. We used patch‐clamp electrophysiology and immunohistochemistry examine its distribution articular cartilage. In cell‐attached patch experiments, application negative pressures pipette (in range 20–200 mmHg) currents six seven patches....
Transient receptor potential vanilloid type 4 (TRPV4) and calcium-activated potassium channels (KCa ) mediate osmosensing in many tissues. Both TRPV4 KCa are found the paraventricular nucleus (PVN) of hypothalamus, an area critical for sympathetic control cardiovascular renal function. Here, we have investigated whether functionally couple to PVN parvocellular neurones characterized, pharmacologically, subtype channel involved.
We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access previously underutilized reduction protecting group chemistries for PET imaging applications. The rapid removal an O-benzyl prepare 2-[18F]fluoroquinolin-8-ol a nitro in synthesis 4-[18F]fluoroaniline were achieved within 3 minutes.
In many growing tissues, slowly dividing stem cells give rise to rapidly proliferating progenitors that eventually exit the cell cycle and differentiate. Growth rates are limited by nutrient availability, but it is unclear which steps of proliferation-differentiation programme particularly sensitive fuel supplies. We examined how deprivation (ND) affects progenitor in ciliary marginal zone (CMZ) amphibian retina, a well-characterised neurogenic niche. show ND specifically blocks...