A5101831174- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Lipid metabolism and disorders
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Memory and Neural Mechanisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Peroxisome Proliferator-Activated Receptors
- Pomegranate: compositions and health benefits
- Liver Diseases and Immunity
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- Cancer Treatment and Pharmacology
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Inflammatory Bowel Disease
- Cholesterol and Lipid Metabolism
Guangdong Academy of Medical Sciences
2022-2025
Guangdong Provincial People's Hospital
2022-2025
Sun Yat-sen University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Southern Medical University
2017-2025
Soochow University
2025
Second Affiliated Hospital of Soochow University
2025
State Key Laboratory of Genetic Engineering
2023-2024
Fudan University
2013-2024
Minzu University of China
2022-2024
Hawthorn ( Crataegus pinnatifida Bunge. var. major ) is an edible and medicinal fruit that very common in food traditional Chinese medicine. Corosolic acid (CA), a pentacyclic triterpenoid, which active component of hawthorn ), has been exhibiting various pharmacological activities such as antidiabetic, antibacterial, anticancer, antiinflammatory, antioxidant effects. The study aimed to evaluate the effect CA on non‐alcoholic steatohepatitis (NASH) mice induced by 60 kcal% high‐fat diet...
PPPs, PC and PEA in different concentrations were found to decrease the total cholesterol (TC) content increase bile acid (TBA) of a human hepatic cell model, so possess lipid-lowering effect.
Abstract Background Kidney renal clear cell carcinoma (KIRC) is the most common subtype of tumor. However, molecular mechanisms KIRC pathogenesis remain little known. The purpose our study was to identify potential key genes related occurrence and prognosis KIRC, which could serve as novel diagnostic prognostic biomarkers for KIRC. Methods Three gene expression profiles from omnibus database were integrated differential expressed (DEGs) using limma package. Enrichment analysis PPI...
Objectives To study the anti-oxidant effects of traditional Mongolian medicine Zha-Chong-Shi-San-Pill ethanol extract (EEZC) on cerebral stroke for future clinical use. Materials and Methods Active components mechanisms EEZC against were predicted analyzed via ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS), network pharmacology, molecular docking. Next, an oxidative damage model was established in bEnd.3 cells using H 2 O to simulate...
Objective. miR-122 is highly abundant in liver and a hepato-specific microRNA. There evidence to show that expression down-regulated human hepatocellular carcinoma (HCC). It not known whether affects the cellular behavior of hepatoma cells. The aim this study was investigate effects on viability apoptosis Material methods. Huh-7 HepG2 cells treated with or antisense RNA (anti-miR-122) were analyzed by adenosine triphosphate (ATP)-based luminescent assay, annexin V-based flow cytometry,...
Polysaccharide of Spirulina platensis (PSP) is a kind water-soluble polysaccharide extracted from platensis. It has been proved to have antitumor, antioxidation, antiaging, and antivirus properties. And it promising prospect for wide application.This study aims identify an extraction process high-purity in through series optimization methods then evaluates its initial antiaging activities.Four kinds methods-hot-water extraction, alkali ultrasonic-assisted freeze-thaw extraction-were compared...
An important reasons for drug relapse is the retrieval of withdrawal memory induced by conditioned context. Previous studies have suggested that basolateral amygdala (BLA) plays an role in context-induced morphine memory. However, downstream neuronal circuits activation BLA remain unknown. Using retrograde labeling, immunohistochemical, and optogenetic approaches, we found that, although neurons projecting to prelimbic cortex (PrL) played memory, they do not exhibit increased expression...
Circular RNAs (circRNAs) play an important role in many neurological diseases and can serve as biomarkers for these diseases. However, the information about circRNAs Parkinson disease (PD) remained limited. In this study, we aimed to determine expression profile PD patients discuss significance of diagnosis PD.Using RNA-sequencing peripheral blood RNAs, showed that a significant number mRNAs or were differentially expressed between normal controls (NCs), which included 273 up-regulated 493...
Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study morphine-induced adaptation in and its functional significance importance to understand mechanism morphine addiction. Previous studies have found number adaptive changes at molecular levels brain. A from our lab showed that increases expression D1 receptors presynaptic terminals coming other structures basolateral amygdala (BLA) played an important role environmental cue-induced retrieval...
Identification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis Qiong Wu,1,2 Bo Zhang,1,2 Yidan Sun,3 Ran Xu,1 Xinyi Hu,4 Shiqi Ren,4 Qianqian Ma,5 Chen Chen,6 Jian Shu,7 Fuwei Qi,7 Ting He,7 Wei Wang,2 Ziheng Wang21Medical School Nantong University, 226001, People's Republic China; 2The Hand Surgery Research Center, Department Surgery, Affiliated Hospital 3Department Oncology, First Teaching Tianjin University Traditional...
Objective Parkinson’s disease (PD) is a degenerative disorder characterized by steady motor function loss. PD pathogenesis remains inconclusive, but aberrant immune responses might play important roles. We hypothesized that imbalance between T helper (Th) 1 and regulatory (Treg) cells was essential in experimental PD. Methods Th1 Treg from the blood of patients with healthy volunteer were measured flow cytometry. Experimental induced mice peritoneal injection...
Background: The clinical burden and natural history of non-alcoholic fatty liver disease (NAFLD) vary globally. We aimed to investigate NAFLD-related mortality profiles in hospitalized patients southern China. Methods: A multicenter retrospective investigation with a 10-year study period (2009–2018) analyzed 10,071 deaths during hospitalization (NAFLD: 2,015; other diseases: 1,140; without 6,916) was performed using multiple cause death analysis. Medical histories biochemistry imaging...
Flavonoids have been demonstrated to cytotoxic activities toward numerous human cancer cells, whereas they little or no effect on normal cells. The flavonoids in traditional Chinese herbs may be promising candidates for the development of novel anti-cancer drugs. Our previous study that CH2Cl2 and 95% ethanol eluate (EE) fractions strongest against cell lines 9 separated from Artemisia sacrorum Ledeb., which is widely used prevent treat diverse diseases Northeast China. In present study, 8...
Nonalcoholic fatty liver disease (NAFLD) is a metabolic mainly on account of hypercholesterolemia and may progress to cirrhosis hepatocellular carcinoma. The discovery effective therapy for NAFLD an essential unmet need. Angiopoietin-like protein 3 (ANGPTL3), critical lipid metabolism regulator, resulted in increased blood lipids was elevated NAFLD. Here, we developed nanobody-heavy chain antibody (VHH-Fc) inhibit ANGPTL3 treatment.In this study, retrieved anti-ANGPTL3 VHH Fc fusion protein,...