A5100408980- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Retinal Diseases and Treatments
- Neural dynamics and brain function
- Autophagy in Disease and Therapy
- Neuroendocrine regulation and behavior
- Plant-based Medicinal Research
- Neurobiology of Language and Bilingualism
- Stress Responses and Cortisol
- Axon Guidance and Neuronal Signaling
- Face Recognition and Perception
- Advanced Memory and Neural Computing
- Autism Spectrum Disorder Research
- Hedgehog Signaling Pathway Studies
- Surgical site infection prevention
- Microbial infections and disease research
- Inflammasome and immune disorders
- Traditional Chinese Medicine Analysis
- Spinal Cord Injury Research
- Hereditary Neurological Disorders
- Salivary Gland Disorders and Functions
- Neural Networks and Applications
Lanzhou University
2024
Changzhou University
2017-2024
Shanghai University
2018-2023
Qilu Hospital of Shandong University
2019-2021
Third Xiangya Hospital
2019-2021
Central South University
2019-2021
Tianjin Medical University General Hospital
2020-2021
Ningbo First Hospital
2021
Huazhong Agricultural University
2021
Wenzhou Medical University
2020
Pb is a potential risk factor for cognition, mainly mediated by enhanced oxidative stress. Resveratrol, natural polyphenol with crucial anti-oxidative property, recently implicated in preventing cognitive deficits normal aging and neurodegenerative disorders. Its beneficial effects have been linked to sirtuin 1(SIRT1) activation. The aim of this work investigate the possible linkage between alterations Pb-induced damage impairment prolonged treatment resveratrol. Male C57BL/6 mice were given...
'Metabolic memory' of early hyperglycaemic environment has been frequently suggested in the progression diabetic retinopathy (DR). Retinal pigment epithelial (RPE) cells are crucial targets for DR initiation following hyperglycaemia. Astragalus polysaccharides (APS) long used as a traditional Chinese medicine treating diabetes. In present study, preventive effects and mechanisms APS on metabolic memory-induced RPE cell death were investigated.The expressions miR-204 SIRT1 determined by...
Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although affected patients are usually treated with surgery combined radiotherapy and chemotherapy, median survival time for GBM still approximately 12‑14 months. Identifying key molecular mechanisms targets of development may therefore lead to improved therapies patients. In present study, clinical significance potential function epithelial membrane protein 1 (EMP1) in gliomas were investigated. Increased EMP1...
Objective Parkinson’s disease (PD) is a degenerative disorder characterized by steady motor function loss. PD pathogenesis remains inconclusive, but aberrant immune responses might play important roles. We hypothesized that imbalance between T helper (Th) 1 and regulatory (Treg) cells was essential in experimental PD. Methods Th1 Treg from the blood of patients with healthy volunteer were measured flow cytometry. Experimental induced mice peritoneal injection...
Metabolic memory is one of the causes diabetic retinopathy, and astragalus polysaccharide (APS) has great advantages in treatment diabetes. However, effect APS on metabolic remains to be investigated.Retinal pigment epithelial cell line ARPE-19 primary retinal cells were used verify mitochondria damage apoptosis induced by high glucose-induced memory. The relationship between miR-182 Bcl-2 was confirmed a luciferase activity assay. Western blotting quantitative reverse-transcriptase...
Parkinson's disease is recognized as the second most common neurodegenerative disorder after Alzheimer's disease, characterized by loss of dopominergic neurons in substantia nigra pars compacta and can be experimentally mimicked use neurotoxin, 1‑methyl‑4‑phenylpyridinium ion (MPP+), vitro models. In this study, we investigated potential protective effects apigenin (AP), galangin genkwanin, naturally occurring plant flavonoids, on MPP+‑induced cytotoxicity cultured rat adrenal...
Metabolic memory contributes to the development of diabetic retinopathy (DR), which is complication diabetes. But it's still unknown how prevent metabolic treat DR. In our study, we want examine function Astragalus polysaccharides (APS) in retinal pigment epithelium (RPE) pretreated with high glucose (HG).ARPE-19 and PRPE cells were exposed HG followed by normal (NG) treatment or without APS. QPCR was used levels miR-195 Bcl-2. MDA SOD detection assays oxidative stress level. Western...
Combination of electroencephalogram (EEG) recording and functional magnetic resonance imaging (fMRI) plays a potential role in neuroimaging due to its high spatial temporal resolution. However, EEG is easily influenced by ballistocardiogram (BCG) artifacts may cause false identification the related features, such as epileptic spikes. There are many methods remove them, however, they do not consider time-varying features BCG artifacts. In this paper, novel method using clustering algorithm...
Random flaps can be used to repair wounds and improve shape functional reconstruction, but inflammation necrosis limit their application. Modified McFarlane flap models were constructed on the backs of rats. We hypothesized that dexmedetomidine (DEX) could survival rate ischemic random flaps. Sixty rats randomly divided into three groups: a low-dose DEX group (DEX-L group, 10 μg/kg/D), high-dose (DEX-H 20 μg/kg/D) control (0.9 % saline equivalent). On day 7 after construction, percentage...
Abstract Background Executive function refers to conscious control in psychological process which relates thinking and action. Emotional decision is a part of hot executive contains emotion logic elements. As kind important social adaptation ability, more attention has been paid recent years. Objective Gambling task can be well performed the study emotional decision. fMRI researches focused on gambling show not completely consistent brain activation regions, this adopted EEG ‐ fusion...
Uveal melanoma (UM) is the most prevalent type of primary intraocular malignancy and prone to metastasize, particularly liver. However, due poor understanding pathogenesis UM, effective therapeutic approaches are lacking. As a phenolic compound extracted from grapes, piceatannol (PIC) exhibits anti‑cancer properties. To best our knowledge, however, effects PIC on UM have not been well investigated. Therefore, in present study, considering impact pyroptosis modulating cell viability,...
Abstract Proteolipid protein 2 (PLP2) is an integral ion channel membrane of the endoplasmic reticulum. The has been shown to be highly expressed in many cancer types, but its importance glioma progression poorly understood. Using publicly available datasets (Rembrandt, TCGA and CGGA), we found that expression PLP2 was significantly higher high‐grade gliomas than low‐grade gliomas. We confirmed these results at level through IHC staining (n = 56) biopsies 16). Kaplan‐Meier analysis...
Diabetic retinopathy (DR) is a diabetic complication and the primary cause of blindness in world. However, treatments DR are challenging given its complicated pathogenesis. Here, we investigated molecular mechanisms by focusing on function E2F1/miR-423-5p/HIPK2/HIF1α/VEGF axis.Cultured retinal endothelial cells (hRMECs, hRECs) were treated with 25 mM glucose to mimic high glucose-induced vitro. Streptozotocin (STZ) was injected into mice induce mice. qRT-PCR, western blotting,...
Siglecs are sialic acid-binding immunoglobulin-like lectins that play an important role in tissue homeostasis, immune response, and pathogen infection. Bacterial sialidases act on natural ligands of Siglecs, interfering with the Siglec-mediated response. Glaesserella parasuis is a porcine bacterial secretes sialidase.
Semaphorin 3A (Sema3A), a member of the Sema family proteins, appears to serve an important role in sepsis and sepsis‑induced immunosuppression has been regarded as crucial regulator involved cellular immune response. However, Sema3A CD4<sup>+</sup> T cell anergy during remains be elucidated. In present study, cecal ligation perforation model lipopolysaccharide (LPS) were used simulate was investigated <em>in vivo</em> vitro</em>. <em>In vivo</em>, serum concentration enhanced exacerbated...
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Individual and collective self are two fundamental self-representations important to human experience. The present study aimed investigate whether individual have essential difference in neural mechanism.Event-related potentials were recorded explore the electrophysiological correlates of a self-referential task which participants asked evaluate trait adjectives suitable describe themselves (individual processing), famous person non-self-referential Chinese (collective processing) or...