A5101733887- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Hippo pathway signaling and YAP/TAZ
- Rice Cultivation and Yield Improvement
- Spine and Intervertebral Disc Pathology
- Brain Metastases and Treatment
- Multiple and Secondary Primary Cancers
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- DNA Repair Mechanisms
- Head and Neck Cancer Studies
- Soil Carbon and Nitrogen Dynamics
- Genomics and Chromatin Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Hedgehog Signaling Pathway Studies
Fujian University of Traditional Chinese Medicine
2020-2025
Qilu Hospital of Shandong University
2013-2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Shanghai Sixth People's Hospital
2023
Shanghai Jiao Tong University
2023
Sichuan University
2015-2023
West China Hospital of Sichuan University
2023
Fudan University
2006-2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism action, however, remains unclear. Here, we evaluated the efficacy FKB treatment human glioblastoma multiforme (GBM) as well molecular basis for its inhibitory effects Approximately 60% GBM cells became senescent after with assessed senescence-associated (SA)-GLB1/SA-β-galactosidase assay. cellular process autophagy potentially contributed to establishment senescence....
The main characteristic of glioma is recurrence, even after intensive multidisciplinary treatment. Studies show that enhanced invasive ability will increase the tumor cells to escape from primary mass, which a key factor contributing relapse and recurrence. In this study, we assessed expression MMP-2, MMP-9, two important matrix metallopeptidases glioma, their suppressors, TIMP-1, TIMP-2 in tissues recurrent patients by immunohistochemistry. Glioma nude mice were used for vitro vivo studies....
Abstract Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with Hippo signaling pathway, which is known to regulate biological properties, including proliferation, tissue regeneration, stem cell biology, as well tumorigenesis. Here we first show that ACTL6A upregulated human gliomas its glioma patient survival. promotes malignant behaviors cells vitro orthotopic xenograft model. In co-immunoprecipitation assays,...
Golgi Membrane Protein 1 (GOLM1), a protein involved in the trafficking of proteins through apparatus, has been shown to be oncogenic variety human cancers. Here, we examined role GOLM1 development glioma. qRT-PCR, immunohistochemistry, and western blot analysis were performed evaluate levels cell lines cohort primary glioma non-neoplastic brain tissue samples. Glioma modified with lentiviral constructs expressing short hairpin RNAs targeting or overexpressing assess function proliferation,...
Abstract Glioblastoma (GBM) is one of the most malignant primary brain tumors and its prognosis very poor. Lysosome‐dependent cell death mainly caused by lysosomal membrane permeabilization (LMP), a process in which lysosome loses integrity contents are released into cytosol. Lysosomotropic agent, kind compound that selectively accumulates lysosomes, important inducers LMP. As newly‐synthetic lysosomotropic Lys05 showed efficient autophagy inhibiting antitumor effect. But mechanisms not well...
Glioblastoma has been seen as the most common malignancy of brain tumor. Emerging reports claimed that SNHG29 (LRRC75A-AS1) was involved in several biological processes via modulation signaling pathway, and served an malignant facilitatorin osteosarcoma. However, specific role glioblastoma remains unknown.RT-qPCR microarray were operated to measure genes expression. Western blot performed examine protein CCK-8 colony formation assays used evaluate cell proliferation. Cell migration tested by...
Scoliosis is a prevalent condition among adolescents, and the spinal manipulation one of conservative treatment methods for scoliosis patients. Impairment in movement function stands out as typical characteristic cases scoliosis. This study utilized single-arm clinical trial design involving 35 patients aged 18 to 20 with idiopathic (IS) Cobb angles ranging from 10° 30°. The protocol consisted sessions three times week, each lasting 40 min, administered over span six weeks. Pre-...
Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although affected patients are usually treated with surgery combined radiotherapy and chemotherapy, median survival time for GBM still approximately 12‑14 months. Identifying key molecular mechanisms targets of development may therefore lead to improved therapies patients. In present study, clinical significance potential function epithelial membrane protein 1 (EMP1) in gliomas were investigated. Increased EMP1...
Background With the expanding population of colorectal cancer (CRC) survivors in United States, one concerning issue is risk developing second primary malignancies (SPMs) for these CRC survivors. The present study attempts to identify incidence characteristics SPMs after diagnosis first colon (CC) and rectal (RC). Methods 189,890 CC 83,802 RC cases were identified from Surveillance, Epidemiology End Results Program (SEER) database. We performed rate analysis on trend both RC. Expected rates...
Abstract It has recently been demonstrated that CXCL12 is absent in colonic carcinoma, and hypermethylation of contributes to CXCL12/CXCR4 signaling carcinoma metastasis. However, the role axis, especially CXCL12, regulation tumor invasiveness largely still unknown. Using real‐time quantitative RT‐PCR assays, we observed CXCR4 expression increased with increasing WHO grade astrocytoma, suggesting may be a marker aggressive biological behavior astrocytoma. Methylation was detected 34.2%...