A5004465845- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- RNA Research and Splicing
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Lipid metabolism and disorders
- Kruppel-like factors research
- Environmental and Analytical Chemistry Studies
- Blood properties and coagulation
- Hemoglobin structure and function
- Lung Cancer Treatments and Mutations
- Erythropoietin and Anemia Treatment
- Flavonoids in Medical Research
- Cancer, Stress, Anesthesia, and Immune Response
Shandong Provincial QianFoShan Hospital
2013-2025
Shandong University
2012-2025
Shandong First Medical University
2009-2024
Abstract We conducted a prospective, multicenter, randomized, controlled clinical trial to compare the efficacy and safety of high‐dose dexamethasone (HD‐DXM) plus recombinant human thrombopoietin (rhTPO), vs HD‐DXM alone in newly diagnosed adult immune thrombocytopenia (ITP) patients. Enrolled patients were randomly assigned receive DXM rhTPO or monotherapy. Another 4‐day course was repeated if response not achieved by day 10 both arms. One hundred arm 96 monotherapy included full analysis...
CircRNA circ_POLA2 has been reported as an oncogene in lung cancer, while its role other malignancies is unknown. This study aimed to explore the of acute myeloid leukemia (AML).The expression levels circ_POLA2, mature miR-34a and precursor bone marrow mononuclear cells (BMMNCs) from AML patients (n = 50) healthy controls were determined by RT-qPCR. Correlations among them analyzed Pearson's correlation coefficient. Overexpression was achieved cell lines, followed measurement precursor. The...
// Guanhua Song 1 , Lulu Shi Yuqi Guo Linchang Yu Lin Wang 2 Xiaoyu Zhang Lianlian Li Yang Han Xia Ren Qiang Kehong Bi 3 Guosheng Jiang Department of Hemato-Oncology, Institute Basic Medicine, Shandong Academy Medical Sciences, Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Shandong, Jinan, China Research Center Medicinal Biotechnology, Qianfoshan Hospital Correspondence to: Bi, e-mail: kehongbi@126.com Jiang, jiangguosh@163.com Keywords: PADI4, methylation,...
Purpose Immune dysregulation plays a key role in acute myeloid leukemia (AML). We aimed to explore the correlation between T helper cell 17 (Th17) and regulatory cells (Tregs) peripheral blood of patients with newly diagnosed (ND) AML bone marrow blast cells, as well minimal residual disease (MRD) before after treatment.
Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as alternative to genetic defects in the inactivation tumor suppressor genes human cancers. The demethylating, dose-dependent effect arsenic trioxide (As2O3) on several tumor-related has already been postulated. However, whether such a demethylating also applies TMS1 gene chronic myeloid leukemia cell line K562 cells not studied so far. aim present study was...
Abstract Affected by differences in the pharmacokinetics (PK) of lenalidomide, toxicity lenalidomide varies among different patients, with serious leading to dose reduction or discontinuation. The PK may be related factors such as patients’ physiological characteristics, pathological characteristics and gene polymorphisms etc., which also affect its toxicity. aim this study is establish a population pharmacokinetic (PPK) model explore associated adverse events (AEs) from perspective. Blood...
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy, and allogeneic transplantation (allo-HSCT) the only curable treatment. The outcomes after transplant are influenced by both disease characteristics patient comorbidities. To develop novel prognostic model to predict post-transplant survival of CMML patients, we identified risk factors applying univariable multivariable Cox proportional hazards regression derivation cohort. In analysis, advanced age (hazard...
The aim of the present study was to investigate demethylation effect arsenic trioxide (As2O3) on secreted frizzled-related protein 1 (SFRP1) gene and its ability inhibit Wingless‑type MMTV integration site family (WNT) pathway in Jurkat cells. Methylation-specific polymerase chain reaction used examine CpG island methylation status SFRP1 leukemia cell lines. In addition, effects cells treatment with different concentrations As2O3 for 48 h were investigated. Reverse transcription‑quantitative...
Objectives：MiR-140 and DNAJC3-AS1 have been proven to play critical roles in cancer biology, while their participations acute myeloid leukemia (AML) are unclear. This study aimed explore the role of miR-140 AML.
 Methods：Analysis expression was done with RT-qPCR. The each other explored overexpression assay. direct interaction between analyzed RNA pull-down subcellular location cellular fractionation Cell proliferation analysis BrdU assay.
 Results：AML patients showed increased...
Abstract Background Endoplasmic reticulum (ER) stress is closely related with the pathological progression of rheumatoid arthritis (RA), and fibroblast-like synoviocytes (FLSs) are known as its resistance against ER stress-induced apoptosis. Studies on overcoming such would provide a novel treatment strategy for RA in clinical setting. Methods IL13Rα1 expression was assessed synovial tissue by RT-qPCR, immunohistology, Western blot. Gain or loss functional analysis applied to evaluate...
To compare the efficacy and toxicity of chemotherapeutic regimen containing pirarubicin mitoxantrone on treatment relapsed or refractory acute myeloid leukemia (AML) in adults.In this open prospective multicentre study, we randomly assigned patients with AML to receive TAE (pirarubicin+cytarabine+etoposide) versus MAE (mitoxantrone + cytarabine etoposide). The were compared between two groups.56 entered clinical trial. complete remission (CR) rate arm was 79.0% 55.6% overall response (OR)...
MicroRNA-129 (miR-129) is known to promote chemosensitivity of many types cancer cells. However, the role miR-129 in acute myeloid leukaemia (AML) unclear. We predicted that premature might interact with circEHBP1, a well-characterized oncogene bladder cancer, and analyzed interaction between circEHBP1 AML.Expression AML patients before after adriamycin (ADR) treatment was determined by RT-qPCR. CircEHBP1 distribution nuclear cytoplasm fractions cells using cellular fractionation assay. The...
Abstract Although it has been shown that abnormal expression of Wilm’s tumor gene 1 (WT1) is associated with the occurrence leukemia, specific mechanism via which induces leukemia cells to differentiate into macrophages remains poorly understood. Based on prediction microRNA miRNA-132-3p miRNA possibly lies upstream WT1 gene, we hypothesized may participate in polarization process through regulating gene. The focus present study was therefore investigate role miRNA-132-3p/WT1 signaling axis...