A5100439182- Neural Networks Stability and Synchronization
- Nonlinear Dynamics and Pattern Formation
- Distributed Control Multi-Agent Systems
- Chaos control and synchronization
- Genomics, phytochemicals, and oxidative stress
- Caching and Content Delivery
- Epigenetics and DNA Methylation
- Network Traffic and Congestion Control
- stochastic dynamics and bifurcation
- Gene Regulatory Network Analysis
- Photosynthetic Processes and Mechanisms
- Mathematical and Theoretical Epidemiology and Ecology Models
- Mobile Agent-Based Network Management
- Plant Reproductive Biology
- Opportunistic and Delay-Tolerant Networks
- Plant Molecular Biology Research
- Light effects on plants
- Mobile Ad Hoc Networks
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Medicinal Plants and Bioactive Compounds
- Bioinformatics and Genomic Networks
- Animal Virus Infections Studies
- Neurological Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
Hunan Agricultural University
2019-2025
Guangdong University of Foreign Studies
2015-2025
Nanfang Hospital
2023-2025
Nanjing Institute of Vegetable Science
2020-2025
Southern University of Science and Technology
2025
Wenzhou Medical University
2019-2025
First Affiliated Hospital of Wenzhou Medical University
2025
Southern Medical University
2023-2025
Guangzhou Medical University
2019-2024
Nankai University
2024
An updated Lnc2Cancer 3.0 (http://www.bio-bigdata.net/lnc2cancer or http://bio-bigdata.hrbmu.edu.cn/lnc2cancer) database, which includes comprehensive data on experimentally supported long non-coding RNAs (lncRNAs) and circular (circRNAs) associated with human cancers. In addition, web tools for analyzing lncRNA expression by high-throughput RNA sequencing (RNA-seq) single-cell RNA-seq (scRNA-seq) are described. was several new features, including (i) Increased cancer-associated entries over...
Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an important role in epigenetic regulation of gene activation and repression. The up-regulated LSD1's expression has been reported several malignant tumors. In current study, we designed synthesized five series 1,2,3-triazole-dithiocarbamate hybrids screened their inhibitory activity toward LSD1. We found that some these compounds, especially compound 26, exhibited most robust inhibition Interestingly, 26...
Abstract Aging in mammals is accompanied by an imbalance of intestinal homeostasis and accumulation mitochondrial DNA (mtDNA) mutations. However, little known about how accumulated mtDNA mutations modulate homeostasis. We observe the small intestine aged male mice, suggesting association with physiological aging. Using polymerase gamma (POLG) mutator mice wild-type we generate progressive mutation burdens. Investigation utilizing organoid technology vivo stem cell labeling reveals decreased...
A size series of ligand-stabilized Ni nanoparticles (NPs) with diameters between 8-24 nm was prepared by solution chemistry, followed solution-phase oxidation atmospheric oxygen at 200 degrees C to form Ni(core)/NiO(shell) NPs shell thicknesses 2-3 nm. In comparison the Fe and Co NPs, require higher temperatures for significant conversion NiO. Transmission electron microscopy diffraction show polycrystalline cores predominantly amorphous shells. SQUID magnetometry measurements were performed...
Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several human cancers and recognized as a promising anticancer drug target. In the current study, we designed synthesized novel series of pyrimidine–thiourea hybrids evaluated their potential LSD1 inhibitory effect. One compounds, 6b, containing terminal alkyne appendage, shown most potent selective inhibitor vitro exhibited strong cytotoxicity against gastric cancer cells. Compound 6b also showed marked...
This paper studies the leader-following consensus problem for a class of strict-feedback multiagent systems with unknown nonlinearities and state time-delays under directed topology. By using backstepping technique, an adaptive control protocol is proposed, where neural networks are employed to neutralize uncertain nonlinearities. To eliminate effects time-delays, Lyapunov–Krasovskii functionals, Young's inequalities used in design process. It notable that computation burden dramatically...
Histone lysine specific demethylase 1 (LSD1) has been recognized as an important modulator in post-translational process epigenetics. Dysregulation of LSD1 implicated the development various cancers. Herein, we report discovery hit compound 8a (IC50 = 3.93 μmol/L) and further medicinal chemistry efforts, leading to generation 15u 49 nmol/L, Ki 16 nmol/L), which inhibited reversibly competitively with H3K4me2, was selective over MAO-A/B. Docking studies were performed rationalize potency 15u....
Abstract Previous studies have suggested that hypoxic responses are regulated by hypoxia-inducible factors (HIFs), which in turn promote the malignant progression of glioblastoma (GBM) inhibiting apoptosis and increasing proliferation; these events lead to a poor prognosis GBM patients. However, there still no HIF-targeted therapies for treatment GBM. We conducted series experiments discovered cells exhibit features indicative present environment. Knocking out HIF1α or HIF2α alone resulted...
Abstract Background Bistability, the capacity to achieve two distinct stable steady states in response a set of external stimuli, arises within biological systems ranging from λ phage switch bacteria cellular signal transduction pathways mammalian cells. On other hand, more and experimental evidence form bimodal population distribution has indicated that noise plays very important role switching bistable systems. However, physiological mechanism underling noise-induced behaviors remains be...
Fractional‐order financial system introduced by W.‐C. Chen (2008) displays chaotic motions at order less than 3. In this paper we have extended the nonlinear feedback control in ODE systems to fractional‐order systems, eliminate behavior. The results are proved analytically applying Lyapunov linearization method and stability condition for fractional system. Moreover numerical simulations shown verify effectiveness of proposed scheme.
// Sai-Qi Wang 1, * , Cong Li-Ming Chang 1 Kai-Rui Zhou Jun-Wei Yu Ke Dong-Xiao Yang Hong-Ge Shi Ran Xiao-Li Li-Ying Ma Hong-Min Liu School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, P.R. China These authors contributed equally to this work Correspondence to: Liu, email: liuhm@zzu.edu.cn Keywords: gastric cancer, paclitaxel resistance, oridonin, synergism, PI3K/Akt pathway Received: April 12, 2016 Accepted: September 02, Published: 21, ABSTRACT Paclitaxel, a taxane,...
Increasing evidence suggests that microRNAs (miRNAs) play important roles in impaired endothelial cell (EC) angiogenesis during aging. However, their exact the aging process remain unclear. We aimed to determine whether miRNAs cause defects ECs and uncover underlying mechanisms. To study miRNA-induced changes aging, we performed microarray analyses on arterial collected from young mice. Using qRT–PCR, showed microRNA-125a-5p (mir-125a-5p) expression was approximately 2.9 times higher old...
CTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order architecture of mammalian genomes. Previous studies have mainly focused on canonical isoform. Here, we explore functions an alternatively spliced human isoform which exons 3 4 are skipped, producing a shorter (CTCF-s). Functionally, find that CTCF-s competes with genome binding binds similar DNA sequence. disrupts CTCF/cohesin binding, alters CTCF-mediated...
Hematopoietic stem cells (HSCs)/progenitor (HPCs) are generated from hemogenic endothelial (HECs) during the endothelial-to-hematopoietic transition (EHT); however, underlying mechanism remains poorly understood. Here, using an array of approaches, including CRSPR/Cas9 gene knockouts, RNA-Seq, ChIP-Seq, ATAC-Seq etc., we report that vitamin C (Vc) is essential in HPC generation human pluripotent cell (hPSC) differentiation defined culture conditions. Mechanistically, found absence Vc fail to...
Broccoli (Brassica oleracea var. italica Plenck) is an important vegetable crop, as it rich in health-beneficial glucosinolates (GSLs). However, the genetic basis of GSL diversity Brassicaceae remains unclear. Here we report a chromosome-level genome assembly broccoli generated using PacBio HiFi reads and Hi-C technology. The final 613.79 Mb size, with contig N50 14.70 Mb. profile content analysis different B. varieties, combined phylogenetic tree analysis, sequence alignment, construction...
Abstract The last decade has witnessed significant progress in organic electrochemical transistors (OECTs) due to their enormous potential applications various bioelectronic devices, such as artificial synapses, biological interfaces, and biosensors. remarkable advance this field is highly powered by the development of novel mixed ionic/electronic conductors (OMIECs). π‐Conjugated polymers (CPs), which are widely used optoelectronics, emerging key channel materials for OECTs. In review,...
Abstract Sulforaphane (SF) is a sulfur (S)‐containing isothiocyanate found in cruciferous vegetables and known for its potent anticancer properties. Broccoli sprouts, particular, are considered safe healthy dietary choices due to their high SF content other beneficial biological activities, such as enhanced metabolite ingestion. The application of selenium (Se) an excellent approach enhance the abundance SF. Previous studies have often focused on gene expression changes synthetic substrates...
This paper studies the distributed state estimation problem for a linear system that is jointly observable with consideration of communication noises and Markovian switching topologies. To address this issue, network observers proposed, where each observer only measures partial output, which may not be sufficient to observe complete system. Subsequently, all within collaborate by sharing their estimated states neighbours through network, facilitating cooperative reconstruction entire at...