A5100758327- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Organic Chemistry Cycloaddition Reactions
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Cyclopropane Reaction Mechanisms
- Chemical Reaction Mechanisms
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Chemical Synthesis and Analysis
- DNA and Nucleic Acid Chemistry
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Advanced biosensing and bioanalysis techniques
- Photochemistry and Electron Transfer Studies
- Synthesis and Biological Evaluation
- Advanced Chemical Physics Studies
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Free Radicals and Antioxidants
- Analytical Chemistry and Sensors
- Advanced Photocatalysis Techniques
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
Shanxi University of Traditional Chinese Medicine
2023
Anhui Medical University
2023
Zhengzhou University
2014-2023
Shandong Jianzhu University
2018-2023
Henan Provincial People's Hospital
2018-2023
Jiang Xi Institute for Drug Control
2023
National Medical Products Administration
2023
Jiangxi University of Traditional Chinese Medicine
2023
Henan Institute of Geological Survey
2023
Henan University
2019-2022
Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an important role in epigenetic regulation of gene activation and repression. The up-regulated LSD1's expression has been reported several malignant tumors. In current study, we designed synthesized five series 1,2,3-triazole-dithiocarbamate hybrids screened their inhibitory activity toward LSD1. We found that some these compounds, especially compound 26, exhibited most robust inhibition Interestingly, 26...
Abstract The host–guest chemistry of metal–organic frameworks (MOFs) has enabled the derivation numerous new functionalities. However, intrinsically chiral MOFs (CMOFs) with helical channels have not been used to realize crystalline circularly polarized luminescence (CPL) materials. Herein, enantiomeric pairs MOF crystals are reported, where achiral fluorophores adhere inner surface via biology‐like H‐bonds and hence inherit helicity host MOFs, eventually amplifying dissymmetry factor ( g...
A C(3)-symmetric Schiff-base example of the new simple, low cost, highly water soluble, and sensitive turn-on fluorescent Zn(2+) chemosensor is described. The sensor was successfully applied to detection intracellular Zn(2+). Moreover, could also serve as a potential recyclable component in sensing materials. Notably, color change so obvious that all recycling process can be seen clearly by naked eye.
Four novel complexes, {[Ni4(HEIDC)4(H2O)8]·2H2O} (1), {[Mn(HEIDC)(4,4′-bipy)0.5(H2O)]·H2O}n (2), [Mn6(EIDC)4(py)(H2O)4]n (3), and {[Cd2(EIDC)(H2EIDC)(4,4′-bipy)1.5]·H2O}n (4) (H3EIDC = 2-ethyl-1H-imidazole-4,5-dicarboxylic acid, 4,4′-bipy 4,4′-bipyridine, py pyridine) have been hydro(solvo)thermally synthesized by fine control over synthetic conditions, such as solvent pH value, structurally characterized. It is shown through single-crystal X-ray diffractions that the ligands H3EIDC can be...
A polar homochiral 3D MOF [{Co2(L)(bpe)(H2O)}·5H2O]n constructed with cobalt(II) and a new ligand N-(1,3-dicarboxy-5-benzyl)-carboxymethylglycine (H4L) accommodates ordered helical water streams in its grooves. It provides the first example of switchable ferroelectric optical behavior through two-step reversible single-crystal to transformation (SCSC) upon desorption/adsorption spirals coordinated molecules, respectively.
Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. With the method RNA sequencing, we found that irradiation (IR) markedly increased expression promotive genes, whereas reduced suppressive genes in murine intestine tissues, when compared with those liver and lung tissues. By using inducer RSL-3 inhibitor liproxstatin-1, essential for IR-induced intestinal injury. Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) an important component execution,...
A water-soluble rhodamine-based derivative (L) has been rationally designed for selective recognition of Al3+ in aqueous medium with good sensitivity. The addition to the solution L induces a remarkable fluorescence enhancement along obvious color change detected by naked eye, due ring-opening mechanism rhodamine spirolactam, which proved single crystal diffraction analyses directly. recognizing behavior investigated both experimentally and computationally. Furthermore, fluorescent probe can...
Two chiral three-dimensional (3-D) coordination polymers, [Cd4(μ3-HPhIDC)2(μ4-HPhIDC)2(H2O)] (1) and two achiral 3-D [Mn1.5(μ3-PhIDC)(H2O)3] (2) [Mn(μ3-HPhIDC)(H2O)]2} (3), have been synthesized by hydro(solvo)thermal reaction, employing 2-phenyl-1H-imidazole-4,5-dicarboxylic acid (H3PhIDC) as organic ligand, characterized single-crystal X-ray diffraction, elemental analyses, IR spectra. Polymer 1 crystallizes in the orthorhombic space group P2(1)2(1)2(1) exhibits a framework, which...
Density functional theory (DFT) calculations have been performed to provide the first detailed computational study on mechanism and enantioselectivity for [4 + 2] cycloaddition reaction of ketenes with N-benzoyldiazenes catalyzed by N-heterocyclic carbenes (NHCs). Two possible mechanisms studied: is "ketene-first" (mechanism A), second novel "diazene-first" B). The calculated results reveal that B more favorable than A because it not only lower energy barrier but also consistent provided...
A highly fluorescent chemosensor based on 1,8-naphthyridine with high sensitivity and selectivity toward Ni2+/Cu2+ over other cations both in aqueous solution a wide pH range (4–10) cellular environments was developed. Counteranions such as acetate, sulfate, nitrate, perchlorate have no influence the detection of metal ions. Ethylenediamine showed situ-prepared Cu2+ complex Ni2+ complex, which can be applied to distinguish Cu2+. The Ni2+-induced fluorescence on–off mechanism revealed...
Herein, a mechanism of stepwise metal-center exchange for specific metal-organic framework, namely, [Zn4 (dcpp)2 (DMF)3 (H2 O)2 ]n (H4 dcpp=4,5-bis(4'-carboxylphenyl)phthalic acid), is disclosed the first time. The coordination stabilities between central metal atoms and ligands as well geometry are considered to be dominant factors in this mechanism. A new magnetic analytical method theoretical model confirmed that reasonable. When metathesis reaction occurs Cu(II) ions framework Zn(II)...
The possible reaction mechanisms of stereoselective [4 + 2] cycloaddition enals and chalcones catalyzed by N-heterocyclic carbene (NHC) have been investigated using density functional theory (DFT). calculated results indicate that the most favorable channel occurs through five steps. first step is nucleophilic attack on enal NHC. Then, there are two consecutive acid (AcOH)-assisted proton-transfer Subsequently, fourth process associated with formation chiral centers, followed dissociation...
The detailed mechanisms and diastereoselectivities of Lewis acid-promoted ketene-alkene [2 + 2] cycloaddition reactions have been studied by density functional theory (DFT). Four possible reaction channels, including two noncatalyzed diastereomeric channels (channels A B) acid (LA) ethylaluminum dichloride (EtAlCl2) catalyzed C D), investigated in this work. calculated results indicate that channel (associated with product R-configurational cycloputanone) is more energy favorable than B the...
In this paper, two possible mechanisms (mechanisms A and B) on the stereoselective [2 + 2] cycloaddition of aryl(alkyl)ketenes electron-deficient benzaldehydes catalyzed by N-heterocyclic carbenes (NHCs) have been investigated using density functional theory (DFT). Our calculated results indicate that favorable mechanism (mechanism A) includes three processes: first step is nucleophilic attack arylalkylketene NHC catalyst to form an intermediate, second intermediate benzaldehyde for...
In this study, a density functional theory (DFT) study has been carried out to investigate the mechanisms of Rh(I)-catalyzed carbenoid carbon insertion into C-C bond reaction between benzocyclobutenol (R1) and diazoester (R2). The calculated results indicate that proceeds through five stages: deprotonation R1, cleavage bond, insertion, intramolecular aldol reaction, protonation alkoxyl-Rh(I) intermediate. We have suggested studied two possible pathways according different coordination...
2-Carboxylphenyl, 3-carboxylphenyl and 4-carboxylphenyl groups were introduced into the 2-position of imidazole-4,5-dicarboxylate system, respectively, obtaining three multi-functional ligands 2-(2-carboxylphenyl)-1H-imidazole-4,5-dicarboxylic acid (o-CPhH4IDC), 2-(3-carboxylphenyl)-1H-imidazole-4,5-dicarboxylic (m-CPhH4IDC) 2-(4-carboxylphenyl)-1H-imidazole-4,5-dicarboxylic (p-CPhH4IDC). Then organic are employed to react with Sr(II) Cd(II) ions. Subsequently, five 3D or 2D polymers,...
The reaction of 2-hydroxybenzophenone derivatives with europium ions has afforded a new family luminescent nonanuclear Eu(III) clusters. Crystal structure analysis the clusters reveals that metal core comprises two vertex-sharing square pyramidal units. Most these complexes show emissions typical Eu3+ ion under visible light excitation (400–420 nm) at room temperature. Photophysical characterization and DFT study reveal correlation between efficiencies electronic features ligands, which can...
The reactions between 1,3-dialkynes and ammonia derivatives (such as hydrazine hydroxylamine) for the formation of five-membered N-heterocycles (i.e. 3,5-disubstituted pyrazole isoxazole) have been investigated using density functional theory (DFT) method. calculated results indicate that favorable mechanism this kind reaction generally contains four processes: (1) Cope-type hydroamination reactants coupled with hydrazine/hydroxylamine-assisted proton transfer process or trimolecular via a...
By hydrothermal reactions of metal salts with two kinds 2-position substituted imidazole- dicarboxylate ligands, 2-(3-methoxyphenyl)-1H-imidazole-4,5-dicarboxylic acid (m-H3MOPhIDC) and 2-(3,4-dimethoxyphenyl)-1H-imidazole-4,5-dicarboxylic (3,4-H3DMOPhIDC), three 3D polymers {[Mn3(m-MOPhIDC)2(H2O)6]·4H2O}n (1), {[Zn3(m-MOPhIDC)2(H2O)6]·4H2O}n (2) [Sr(3,4-H2DMOPhIDC)2]n (3), 1D [Cd2(3,4-HDMOPhIDC)2(H2O)4]n (4) [Zn(3,4-HDMOPhIDC)(phen)]n (5) (phen = 1,10-phenanthroline) have been afforded...
Recently, Smith and co-workers reported an interesting work that provides a facile approach to access substituted trifluoromethyl dihydropyranones with two contiguous stereocenters by utilizing the α,β-unsaturated ketones as substrate for NHC-catalyzed [4 + 2] cycloadditions. The most significant point of this reaction lies in capability introducing substituents C(5) position dihydropyranones. In present study, we performed detailed DFT investigations toward catalytic mechanism reaction,...