A5090301206- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Supercapacitor Materials and Fabrication
- Bone and Dental Protein Studies
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Inflammation biomarkers and pathways
- Periodontal Regeneration and Treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Advanced Battery Materials and Technologies
- Cancer Cells and Metastasis
- Adenosine and Purinergic Signaling
- Advancements in Battery Materials
- Inflammatory Bowel Disease
Jiangsu University
2021-2024
Affiliated Hospital of Jiangsu University
2021-2024
Central South University
2024
Abstract Implantable medical devices have played an important role in human medicine recent decades. However, traditional implanted require battery replacement and a second surgery for device removal, which can cause pain to the patient. This work presents biodegradable triboelectric nanogenerator (BI-TENG) made from both natural synthetic materials that is utilized collect mechanical energy vivo transduce it into electricity. Reed film polylactic acid were chosen among different as layers...
Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. With the method RNA sequencing, we found that irradiation (IR) markedly increased expression promotive genes, whereas reduced suppressive genes in murine intestine tissues, when compared with those liver and lung tissues. By using inducer RSL-3 inhibitor liproxstatin-1, essential for IR-induced intestinal injury. Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) an important component execution,...
Epithelial-mesenchymal transition (EMT) is closely associated with tumor invasion and metastasis.However, key regulators of EMT in pancreatic ductal adenocarcinoma (PDAC) need to be further studied.Bioinformatics analyses cancer public datasets showed that glycogen phosphorylase L (PYGL) expression elevated quasimesenchymal PDAC (QM-PDAC) positively EMT.In vitro cellular experiments confirm PYGL as a crucial regulator cells.Functionally, overexpression promotes cell migration facilitates...
Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target inflammation-associated diseases. However, little is known about specific roles purinergic receptors in IBD. In present study, expression profile was screened public Gene Expression Omnibus (GEO) datasets, and we found that P2RX1 significantly upregulated inflamed colon tissues. Then, receptor genetically ablated background...
Abstract Na 4 Fe 3 (PO ) 2 P O 7 cathode exhibits extensive potential for high‐power applications, owing to its large sodium ion diffusion channels, low cost, and suitable operating voltage. However, it suffers significant capacity degradation due the inevitable NaFePO impurity. Herein, a synergistic strategy is proposed that integrates high entropy doping with vacancy engineering, which not only preserves phase purity but also provides additional active sites further stabilizes crystal...
Excessive neutrophil extracellular trap (NET) formation is an important contributor to sepsis-induced acute lung injury (ALI). Recent reports indicate that platelets can induce formation. However, the specific mechanism remains unclear. Tph1 gene, which encodes rate-limiting enzyme for peripheral 5-hydroxytryptophan (5-HT) synthesis, was knocked out in mice simulate 5-HT deficiency. Cecal ligation and puncture (CLP) surgery performed sepsis. We found deficiency reduced NET tissues,...
The combination of immune checkpoint inhibitors (ICIs) and radiotherapy has shown promise in the treatment metastatic non‑small cell lung cancer (NSCLC). present meta‑analysis aimed to determine efficacy safety combining (RT) ICIs for NSCLC. PubMed, Google Scholar, Cochrane Library Web Science databases were searched relevant articles up February 1, 2023. Post‑therapy outcomes such as progression‑free survival (PFS), complete response, partial response (PR), progressive disease (PD), stable...
To observe the effect of peripheral 5-hydroxytryptophan (5-HT)-induced neutrophil extracellular trap (NET) on lung injury in septic mice.Wild-type (WT type) and Tph1 knockout (KO) C57 mice (6-8 weeks) were selected divided into WT sham group, sepsis Tph1KO group according to random number table method. Mice received surgery (only open abdominal cavity flip cecum without ligation puncture, then close cavity); cecal perforature (CLP) establish model. The sacrificed 12 hours after operation,...
Abstract Immunotherapy has brought great benefits to tumor patients. However, due the relatively low response rate, its further application is limited. Single-cell RNA sequencing (scRNA-seq) a powerful tool for characterizing transcriptome at single-cell resolution, and of scRNA-seq revolutionized knowledge immune microenvironment heterogeneity. It can accurately measure individual cells in find fine differences cell subsets, offer new candidate which have potential be therapeutics targets....