A5021855673- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Immune cells in cancer
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Gut microbiota and health
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Pancreatic and Hepatic Oncology Research
- Laser Material Processing Techniques
- Lung Cancer Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Plant Molecular Biology Research
Jiangsu University
2014-2025
Affiliated Hospital of Jiangsu University
2021-2025
First Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Xi'an Jiaotong University
2025
Sichuan University
2025
First Affiliated Hospital of Xiamen University
2024-2025
Xiamen University
2011-2025
West China Hospital of Sichuan University
2025
Zunyi Medical University
2025
First Affiliated Hospital of Soochow University
2016-2024
Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes neutrophil regulation remains unclear. We investigated the effects gastric cancer cell-derived (GC-Ex) on activation neutrophils elucidated underlying mechanisms. GC-Ex prolonged survival induced expression inflammatory factors neutrophils. GC-Ex-activated neutrophils, turn, promoted cell...
Mesenchymal stem cells (MSCs) play an important role in chemoresistance. Exosomes have been reported to modify cellular phenotype and function by mediating cell-cell communication. In this study, we aimed investigate whether exosomes derived from MSCs (MSC-exosomes) are involved the resistance chemotherapy gastric cancer explore underlying molecular mechanism. We found that MSC-exosomes significantly induced of 5-fluorouracil both vivo ex vivo. antagonized 5-fluorouracil-induced apoptosis...
Abstract Implantable medical devices have played an important role in human medicine recent decades. However, traditional implanted require battery replacement and a second surgery for device removal, which can cause pain to the patient. This work presents biodegradable triboelectric nanogenerator (BI-TENG) made from both natural synthetic materials that is utilized collect mechanical energy vivo transduce it into electricity. Reed film polylactic acid were chosen among different as layers...
Exosomes are nano-sized membrane vesicles secreted by both normal and cancer cells. Emerging evidence indicates that cells derived exosomes contribute to progression through the modulation of tumor microenvironment. However, effects from gastric on macrophages not well understood. In this study, we investigated biological role in activation macrophages. We demonstrated activated express increased levels proinflammatory factors, which turn promoted cell proliferation migration. addition,...
Emerging evidence indicate that mesenchymal stem cells (MSCs) affect tumor progression by reshaping the microenvironment. Neutrophils are essential component of microenvironment and critically involved in cancer progression. Whether phenotype function neutrophils is influenced MSCs not well understood. Herein, we investigated interaction between gastric cancer-derived (GC-MSCs) explored biological role this interaction. We found GC-MSCs induced chemotaxis protected them from spontaneous...
Emerging evidence indicates that inappropriate cell-cell fusion might contribute to cancer progression. Similarly, mesenchymal stem cells (MSCs) can also fuse with other spontaneously and capable of adopting the phenotype cells. The aim our study was investigate role MSCs participated cell in tumorigenesis gastric cancer. We fused human umbilical cord (hucMSCs) vitro by polyethylene glycol (PEG), hybrid were sorted flow cytometer. growth migration hybrids assessed counting、cell colony...
Epithelial-mesenchymal transition (EMT) is closely associated with tumor invasion and metastasis.However, key regulators of EMT in pancreatic ductal adenocarcinoma (PDAC) need to be further studied.Bioinformatics analyses cancer public datasets showed that glycogen phosphorylase L (PYGL) expression elevated quasimesenchymal PDAC (QM-PDAC) positively EMT.In vitro cellular experiments confirm PYGL as a crucial regulator cells.Functionally, overexpression promotes cell migration facilitates...
The stem cell factor SALL4 (Sal-like protein 4) plays important roles in the development and progression of cancer. is critically involved tumour growth, metastasis therapy resistance. However, underlying mechanisms responsible for oncogenic have not been well characterized. In this study, we demonstrated that knockdown by short hairpin RNA greatly inhibited proliferation, migration invasion gastric cancer cells. We further confirmed inhibitory effects on cells using a tetracycline-inducible...
The contact between the dialysis membrane and blood can induce oxidative stress thrombosis, causing organ damage impaired toxin clearance. To date, selection of anticoagulants has focused on mechanisms inhibiting white, but not red (erythrocytes) thrombus formation. In present study, polyethersulfone (PES) membranes are modified with antioxidant drug tiopronin; physicochemical properties performance Tio-PES evaluated. effects erythrocyte thrombosis evaluated in terms morphology,...
To achieve the entangling gate fidelity above quantum error correction threshold, it is critical to suppress errors due experimental imperfection. We consider M\o lmer-S\o rensen gates in trapped-ion systems, and develop a general approach family of noise sources that appeared as either symmetric or asymmetric errors. Using time-average displacement minimization technique, both displacement-dependent part are eliminated. Then, by analyzing tangent space displacement-independent errors, we...