A5074116919- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Ziziphus Jujuba Studies and Applications
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Aluminum Alloys Composites Properties
- Esophageal and GI Pathology
- Toxin Mechanisms and Immunotoxins
- Gastric Cancer Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Renal and related cancers
- RNA modifications and cancer
- Hydrogen Storage and Materials
- Ginseng Biological Effects and Applications
- Biomarkers in Disease Mechanisms
- Magnesium Alloys: Properties and Applications
- Immune cells in cancer
- ATP Synthase and ATPases Research
- Ginger and Zingiberaceae research
Fujian Medical University
2019-2025
Union Hospital
2019-2025
Beijing University of Chinese Medicine
2024
Jiangsu University
2015-2017
Neoadjuvant chemoimmunotherapy (nICT) has emerged as a novel and promising treatment model for esophageal squamous cell carcinoma (ESCC). However, the optimal interval to esophagectomy after nICT remains unclear. This study aimed explore impact of prolonged (7-10 weeks) on short- long-term outcomes compared standard (4-6 weeks). was multicenter retrospective cohort analysis, including three centers. Patients were diagnosed with locally advanced ESCC (cT3-4a or cN+) received radical resection...
Abstract Gastric cancer (GC) remains the fifth most common worldwide. Heat-shock protein 90 (HSP90) has become an attractive therapeutic target in treating cancers, because of its abnormally high expression cancers. Several successful cases HSP90 inhibitors capable inhibiting GC inspired us to try ganetespib, a clinically promising and actively investigated second-generation inhibitor treatment. In our study, we show that ganetespib markedly reduced growth MGC-803 also significantly...
The stem cell factor SALL4 (Sal-like protein 4) plays important roles in the development and progression of cancer. is critically involved tumour growth, metastasis therapy resistance. However, underlying mechanisms responsible for oncogenic have not been well characterized. In this study, we demonstrated that knockdown by short hairpin RNA greatly inhibited proliferation, migration invasion gastric cancer cells. We further confirmed inhibitory effects on cells using a tetracycline-inducible...
Abstract Objective The objective of the study was to explore whether Suanzaoren (Semen Ziziphi Spinosae, SZS) extract could improve insomnia by inhibiting p38 mitogen-activated protein kinase (p38MAPK)/nuclear factor-κB (NF-κB) signaling pathway. Methods Forty SPF-grade Sprague-Dawley (SD) rats were included in study, with 10 randomly selected serving as control group. remaining injected intraperitoneally p-chlorophenylalanine (PCPA) for 6 days establish an model. After successful modeling,...
In current work, the influences of hot extrusion and rolling treatments on microstructure texture developments, as well mechanical properties Mg–1.5Gd– 1.5Nd (wt.%) alloy were investigated. It was shown that underwent completely dynamic recrystallization during thermal-mechanical processing, resulting in fine equiaxial grain structure. Especially for treatment heavy deformation led to even smaller size alloy. Unlike strong basal textures obtained conventional Mg sheets, extruded rolled...
Abstract IL-1RA has been reported to function as tumor suppressor in a variety of tumors, but its and mechanism esophageal cancer remains largely unknown. Our previous studies have shown that is downregulated primary cancer(EC), this downregulation closely related TNM staging survival prognosis. In study, we observed over-expression inhibits proliferation, migration, growth cells(ESCC), the expression secretion VEGF, angiogenesis. Further overexpression transmission PI3K/NF-kappaB. Taken...