A5101589060- Drug Transport and Resistance Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Pneumonia and Respiratory Infections
- Lipoproteins and Cardiovascular Health
- Antibiotics Pharmacokinetics and Efficacy
- Paraquat toxicity studies and treatments
- MicroRNA in disease regulation
- Neonatal Health and Biochemistry
- Acute Lymphoblastic Leukemia research
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Virus-based gene therapy research
- Diabetic Foot Ulcer Assessment and Management
- Antibiotic Resistance in Bacteria
- Neurogenesis and neuroplasticity mechanisms
- Organ Transplantation Techniques and Outcomes
- Wound Healing and Treatments
- Effects of Radiation Exposure
- FOXO transcription factor regulation
- Pregnancy and Medication Impact
- Heat shock proteins research
- Tissue Engineering and Regenerative Medicine
Shanxi University
2024
Jiangnan University
2015-2024
Shandong University
2009-2024
Jining First People's Hospital
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Ministry of Education of the People's Republic of China
2024
Chengdu Military General Hospital
2024
Shanghai First Maternity and Infant Hospital
2022
Shanxi Agricultural University
2019
Jinan Central Hospital
2009-2018
Blood vessels in the tumor periphery have high pericyte coverage and are resistant to vascular disrupting agents (VDAs). VDA treatment resistance leads a viable peripheral rim that contributes failure disease recurrence. Here, we provide evidence support hypothesis shifting target of VDAs from vessel endothelial cells pericytes disrupts rim, circumventing resistance. Through chemical engineering, developed Z-GP-DAVLBH (from tubulin-binding desacetylvinblastine monohydrazide [DAVLBH]) as...
Subarachnoid hemorrhage (SAH) can induce apoptosis in many regions of the brain including cortex and hippocampus. However, few studies have focused on hypothalamus after SAH. Although some antiapoptotic strategies been developed for SAH, such as anti-tumor necrosis factor-alpha (TNF-α) antibody, molecular mechanisms underlying this condition yet to be elucidated. Therefore, purpose study was evaluate whether SAH could identify potential actions anti-TNF-α a therapeutic regimen, upon...
Endothelial cell injury is a critical component of atherosclerosis and hypertension. Vaccarin considered to be potential benefit in the treatment vascular diseases. The aim present study was evaluate possible effects vaccarin human EA·hy926 cells induced by high glucose, investigate its underlying mechanism prevention glucose‑induced injury. In study, were exposed 90, 180 270 mM glucose for 24 h, examined using sulforhodamine B assay. Following with it found that stimulated injury, resulting...
Background: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterized by chronic inflammation, insulin resistance, and islet cell damage. The prevention of T2DM its associated complications an urgent public health issue that affects hundreds millions people globally. Numerous studies suggest disturbances in gut metabolites are important driving forces for the pathogenesis diabetes. However, functions mechanisms action most commensal bacteria remain largely unknown. Methods:...
Radiotherapy is the main locoregional control modality for a number of types malignant tumors, including glioblastoma. However, radiotherapy fails to prevent recurrence in numerous patients due intrinsic radioresistance cancer cells. Cell senescence significant tumor suppressor mechanisms and closely associated with Bmi-1 has been proposed be an oncogene that can induce anti-senescence The present study investigated response U87 glioma cells radiation exposure role following radiotherapy....
Melanocytes are derived from neural crest stem cells in the embryonic stage. In mature melanocytes, a series of complex enzyme-catalyzed reactions leads to production melanins, which determine hair and skin colors animals. The process melanogenesis is can be regulated by mRNA, microRNAs (miRNAs) long noncoding RNAs (lncRNAs) genes. MiRNAs type endogenous RNA approximately 22 nt size that predominantly regulate gene expression inhibiting translation. miR-380-3p candidate miRNA potentially...
Chronic wound repair is a common complication in patients with diabetes mellitus, which causes heavy burden on social medical resources and the economy. Hypaphorine (HYP) has good anti-inflammatory effect, chitosan (CS) used treatment of wounds because its antibacterial effect. The purpose this research was to investigate role mechanism HYP-nano-microspheres for diabetic rats. morphology HYP-NPS observed by transmission electron microscopy (TEM). RAW 264.7 macrophages were assess...
Genes from Perilla frutescens and Ocimum basilicum were introduced into N. tabacum L. var. HHY via distant hybridization, the new-type tobacco varieties “Zisu” “Luole” developed, with noticeable differences in chemical composition. Smoking is leading cause of chronic obstructive pulmonary disease (COPD), its pathogenesis complex. In present study, 48 male Sprague-Dawley (SD) rats randomly divided four groups, namely, control, “HHY”, “Luole”, then exposed to fresh air/cigarette smoke (CS) for...
To evaluate the population pharmacokinetics of cefoperazone in children and establish an evidence-based dosing regimen using a developmental pharmacokinetic-pharmacodynamic approach order to optimize treatment.A model-based, open-label, opportunistic-sampling pharmacokinetic study was conducted China. Blood samples from 99 cefoperazone-treated were collected quantified by HPLC/MS. NONMEM software used for analysis. This registered at ClinicalTrials.gov (NCT03113344).A two-compartment model...
Objectives: Augmented renal clearance (ARC) of primarily renally eliminated antibacterial agents may result in subtherapeutic antibiotic concentrations and, as a consequence, worse clinical outcomes. Cefathiamidine is frequently used empirical antimicrobial therapy children with ARC, but pharmacokinetic studies infants are lacking. This population study ARC was conducted to determine optimal dosing regimens cefathiamidine. Methods: The pharmacokinetics 20 treated Plasma samples...
First dose prediction is challenging in neonates. Our objective this proof-of-concept study was to perform a pharmacokinetic (PK) bridging from juvenile mice neonates for drugs metabolized by CYP3A. We selected midazolam and clindamycin as model drugs. developed population PK models using NONMEM. The parameters of these two were used bridge different correction methods. results evaluated the fold-error 0.5- 1.5-fold. Simple allometry with without factor maximum lifespan potential could be...
Considering prior investigations on reductions of renal multidrug resistance-associated protein (MRP) 2 and 4 transporters in mice with acute lymphoblastic leukemia (ALL), we sought to characterize the underlying mechanisms responsible for IL-6/STAT3/PXR-mediated changes expression MRP2 MRP4 ALL.ALL xenograft models were established intravenously injected methotrexate (MTX) MRPs substrate NOD/SCID mice. Protein associated detected by Western blotting immunocytochemistry. Plasma...