A5015736911- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Immune cells in cancer
- Neonatal Respiratory Health Research
- NF-κB Signaling Pathways
- Paraquat toxicity studies and treatments
- Biofuel production and bioconversion
- Ferroptosis and cancer prognosis
- Lipoproteins and Cardiovascular Health
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Anesthesia and Sedative Agents
- Circular RNAs in diseases
- Caveolin-1 and cellular processes
- Microbial Metabolic Engineering and Bioproduction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sulfur Compounds in Biology
- Effects of Radiation Exposure
- Curcumin's Biomedical Applications
Jiangnan University
2016-2025
Wuxi Fourth People's Hospital
2024
Xuzhou Medical College
2004-2012
Nanjing Medical University
2002-2008
Xiaomi (China)
2003
Abstract Background Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which caused by severe oxidative stress injury, has been major cause accidental worldwide. The latest evidences indicate nuclear factor (erythroid-derived 2)-like 2 (Nrf2) suppress ferroptosis and maintain cellular redox balance. Here, we test the hypothesis activation Nrf2 pathway attenuates...
Photodynamic therapy (PDT) has attracted wide attention due to its distinct advantages in cancer treatment. Herein, a kind of red emissive carbon dots (R-CDs) was synthesized from methylene blue (MB) and phosphate through hydrothermal method. The resultant R-CDs display good biocompatibility, photostability, high singlet oxygen (1O2) yield (0.91); thus, they have been successfully applied the PDT study vitro. More importantly, show noninfective property DNA, which is substantially different...
Fabricated Ag@Au core–shell nanoparticle (CS NP) assemblies exhibit pronounced and reverse chiral bisignate plasmonic signals spanning 400 to 580 nm, in comparison Ag NP assemblies. The time-dependent chiro-optical response of that shift with shell deposition is systematically recorded. Chiral CS first achieve the special discrimination circulating tumor cells HER2 overexpression. As a service our authors readers, this journal provides supporting information supplied by authors. Such...
Dehydrocostus lactone (DHL), a natural sesquiterpene isolated from the traditional Chinese herbs Saussurea lappa and Inula helenium L., has important anti-inflammatory properties used for treating colitis, fibrosis, Gram-negative bacteria-induced acute lung injury (ALI). However, effects of DHL on Gram-positive macrophage activation ALI remains unclear. In this study, we found that inhibited phosphorylation p38 MAPK, degradation IκBα, nuclear translocation NF-κB p65, but enhanced...
Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. Studies performed with activators indicated that it protects cells from ischemia/ reperfusion (I/R) injury. The protective effects of H2S against I/R injury also have been recognized. Hence, the present study was designed to explore whether Sirt1/PGC-1α participates protection exogenous postconditioning isolated rat hearts. Isolated hearts were...
Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c has demonstrated protective effects against various diseases by mitigating injury. C57BL/6 mice were exposed 20 Gy irradiation (IR) received daily intraperitoneal injections for 2 weeks. significantly ameliorated tissue damage, inflammation,...
Radiation-induced lung injury (RILI) is a prevalent complication of thoracic tumor radiotherapy and accidental radiation exposure. Pyrroloquinoline quinone (PQQ), novel vitamin B, plays crucial role in delaying aging, antioxidation, anti-inflammation, antiapoptosis. This study aims to investigate the protective effect mechanisms PQQ against RILI. C57BL/6 mice were exposed 20 Gy dose X-ray on entire thorax with or without daily oral administration for 2 weeks. effectively mitigated...
Short-chain fatty acids (SCFAs), especially propionate, originate from the fermentation of dietary fiber in gut and play a key role inhibiting pulmonary inflammation. Chronic inflammation may induce an epithelial–mesenchymal transition (EMT) alveolar epithelial cells result fibrotic disorders. This study was designed to investigate beneficial effect sodium propionate (SP) on lipopolysaccharide (LPS)-induced EMT. In cultured BEAS-2B cells, protein expression levels E-cadherin, α-smooth muscle...
Alveolar arrest and the impaired angiogenesis caused by chronic inflammation oxidative stress are two main factors in bronchopulmonary dysplasia (BPD). Short-chain fatty acids (SCFAs), especially propionate, possess anti-oxidant anti-inflammatory effects. The present study was designed to examine roles of sodium propionate (SP) on lipopolysaccharide (LPS)-challenged BPD its potential mechanisms.WT, Nrf2-/- mice pulmonary microvascular endothelial cells (HPMECs) were used this study. LPS...
Methicillin-resistant Staphylococcus aureus (MRSA) are a critical predisposing factor of sepsis in the clinic. As product human energy metabolism and immune response, itaconate can effectively reduce inflammation body. This research employed 4-octyl (4-OI) to illustrate that exerted anti-inflammatory effects protect body from acute lung injury (ALI) induced by MRSA.HE staining immunohistochemistry used evaluate MRSA-induced ALI mice. WB qPCR were verify effect 4-OI on oxidative stress caused...
Intrauterine growth restriction (IUGR), one of the major complications pregnancy, is characterized by low birth weight and results in higher risks for long-term problems including developing metabolic cardiovascular diseases. Short-chain fatty acids (SCFAs), especially propionate, have been reported to correct glucose lipid disorders We hypothesized that maternal propionate supplementation could prevent disturbance hypoxia-induced IUGR. Here, our study, hypoxia was induced from gestational...
The malfunction of vascular smooth muscle cells (VSMCs) is an initiating factor in the pathogenesis pathological remodeling, including hypertension-related lesions. MicroRNAs (miRNAs) have been implicated VSMC proliferation and migration numerous cases cardiovascular remodeling. evidence for regulatory role miR-155-5p development system has emerging. However, it was previously unclear whether participated VSMCs under hypertensive conditions. Thus, we aimed to define exact action by...