A5100443985- Advanced Sensor and Energy Harvesting Materials
- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Conducting polymers and applications
- Ovarian function and disorders
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Ovarian cancer diagnosis and treatment
- Advancements in Transdermal Drug Delivery
- Supercapacitor Materials and Fabrication
- Skin Protection and Aging
- Reproductive System and Pregnancy
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Sepsis Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- NF-κB Signaling Pathways
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
Chinese People's Liberation Army
2024-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Huazhong University of Science and Technology
2005-2025
Central Hospital of Wuhan
2019-2025
Chengdu Military General Hospital
2025
Jinan University
2022-2024
Northwest University
2024
Tongji Hospital
2019-2024
Ministry of Education of the People's Republic of China
2022-2023
Hunan University of Science and Engineering
2023
PINK1 and Parkin mediate mitophagy, the cellular process that clears dysfunctional mitochondria. Mitophagy is regulated by mitochondrial dynamics, but molecules linking these two processes remain poorly understood. Here, we show Sam50, core component of sorting assembly machinery (SAM), a critical regulator dynamics PINK1-Parkin-mediated mitophagy. In response to Sam50 depletion, normal tubular mitochondria are first fragmented subsequently merged into large spheres. interacts with...
Background Oxidative injury to retinal pigment epithelium (RPE) and photoreceptors has been linked a number of diseases, including age-related macular degeneration (AMD). Reactive oxygen species (ROS)-mediated gene expression extensively studied at transcriptional levels. Also, the post-transcriptional control level translational regulation recently reported. However, microRNA (miRNA/miR)-mediated in human RPE cells not thoroughly looked at. Increasing evidence points potential role miRNAs...
Chemotherapy-induced ovarian aging not only increases the risk for early menopause-related complications but also results in infertility young female cancer survivors. Oogonial stem cells have ability to generate new oocytes and thus provide opportunities treating infertility. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol derived from plants, that has been shown positive effects on longevity redox flow lipid metabolism preventive function against certain tumors. To...
The demand for flexible, efficient, and self-powered cochlear implants applied to remedy sensorineural hearing loss caused by dysfunctional hair cells remains urgent. Herein, we report an acoustic core–shell resonance harvester the application of artificial cochleae based on piezo-triboelectric effect. Integrating dispersed BaTiO3 particles as cores porous PVDF-TrFE shells, harvest devices with ingenious structures exhibit outstanding properties (Voc = 15.24 V, DAsc 9.22 mA/m2). principle...
Herein, we report a remotely controlled soft robot employing photoresponsive nanocomposite synthesized from liquid crystal elastomers (LCEs), high elastic form-stable phase change polymer (HEPCP), and multiwalled carbon nanotubes (MWCNTs). Possessing two-stage deformation upon exposure to near-infrared (NIR) light, the LCE/HEPCP/MWCNT (LHM) allows exhibit an obvious, fast, reversible shape with low detection limitations. In addition bending of LCE molecular chains itself, HEPCP in composite...
Due to the stratum corneum barrier, resveratrol is difficult be absorbed transdermally, limiting its anti-aging and skin-brightening effects. Furthermore, there a lack of systematic studies on efficacy in human skin, especially three-dimensional skin models clinical trials. To overcome low transdermal delivery issue, we encapsulated into nanoliposomes using high-pressure homogenization method develop an efficient drug system, systematically evaluated via cell line models, model skin. The...
Location is a critical determinant in dictating the cellular function of protein kinase C (PKC). Scaffold proteins contribute to localization by poising PKC at specific intracellular sites. Using yeast two-hybrid screen, we identified centrosomal pericentrin as scaffold that tethers betaII centrosomes. Co-immunoprecipitation studies reveal native interact cells. Co-overexpression show interaction mediated C1A domain and segment within residues 494-593. Immunofluorescence analysis reveals...
Dehydrocostus lactone (DHL), a natural sesquiterpene isolated from the traditional Chinese herbs Saussurea lappa and Inula helenium L., has important anti-inflammatory properties used for treating colitis, fibrosis, Gram-negative bacteria-induced acute lung injury (ALI). However, effects of DHL on Gram-positive macrophage activation ALI remains unclear. In this study, we found that inhibited phosphorylation p38 MAPK, degradation IκBα, nuclear translocation NF-κB p65, but enhanced...
Abstract High‐performance damping materials are significant toward reducing vibration and maintaining stability for industrial applications. Herein, a yolk–shell piezoelectric mechanism is reported, which can enhance mechanical energy dissipation improve capability. With the addition of particles carbon nanotube (CNT) conductive network, properties various resin matrices enhanced with path to electrical heat energy. Particularly, peak loss factor epoxy composites reaches 1.91 tan δ area...
Face masks, which serve as personal protection equipment, have become ubiquitous for combating the ongoing COVID-19. However, conventional electrostatic-based mask filters are disposable and short-term effective with high breathing resistance, causing respiratory ailments massive consumption (129 billion monthly), intensifying global environmental pollution. In an effort to address these challenges, introduction of a piezoelectric polymer was adopted realize charge-laden melt-blown via...
Tat stimulation of HIV-1 transcriptional elongation is species-specific and believed to require a specific cellular cofactor present in many human primate cells but not nonpermissive rodent cells. Human P-TEFb, composed Cdk9 cyclin T1, general transcription factor that phosphorylates the C-terminal domain RNA polymerase II. Previous studies have also implicated P-TEFb as Tat-specific and, particular, T1 responsible for activation. To obtain functional evidence support these hypotheses, we...
Abstract Objectives Luteolin is a naturally occurring flavonoid found in many vegetables, fruits and medicinal plants. The migration proliferation of vascular smooth muscle cells (VSMCs) are the critical pathological processes various cardiovascular diseases, such as atherosclerosis. In this study, we investigated effect luteolin its latent mechanism on VSMCs stimulated by hydrogen peroxide (H2O2). Methods VSMC cell viability was assayed using...
The centralspindlin complex, which is composed of MKLP1 and MgcRacGAP, one the crucial factors involved in cytokinesis initiation. Centralspindlin localized at middle central spindle during anaphase then concentrates midbody to control abscission. A number proteins that associate with have been identified. These associating regulate furrowing abscission coordination centralspindlin. recent study identified a novel partner, called Nessun Dorma, essential for germ cell Drosophila melanogaster....
： Introduction: Many reports indicate that the occurrence of multiple myeloma (MM) is closely related to inflammation and immunity. Although survival rates have been gradually improving in recent years, cure rate still not optimistic enough. Therefore, it necessary continue exploring causes MM. Method: This study utilizes Mendelian randomization (MR) analysis establish connection between inflammatory factors, immune cells, Results: In studies, a significant correlation was observed...
<title>Abstract</title> Tenosynovial giant cell tumor (TGCT) is a rare neoplasm closely associated with dysregulation of the colony-stimulating factor 1(CSF1)/CSF1R signaling pathway, faces high recurrence rates despite surgical intervention, prompting exploration CSF1R inhibitors like pexidartinib. This retrospective pharmacovigilance study analyzed pexidartinib-associated adverse events (AEs) from FDA Adverse Event Reporting System (FAERS) data (Q4 2019–Q3 2024), employing...
This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) investigating potential prognostic value of serum in adult patients with COVID-19. 481 COVID-19 were consecutively included this from January 2, 2020, followed up to April 15, 2020. All clinical laboratory data definite outcomes reviewed. For every measure, grouped into quartiles according C. The highest level was significantly related more severe inflammatory...
This study aimed to explore the role of GRP78-mediated endoplasmic reticulum stress (ERS) in synergistic inhibition colorectal cancer by epigallocatechin-3-gallate (EGCG) and irinotecan (IRI). Findings showed that EGCG alone or combination with can significantly promote intracellular GRP78 protein expression, reduce mitochondrial membrane potential ROS RKO HCT 116 cells, induce cell apoptosis. In addition, glucose regulatory 78 kDa (GRP78) is over-expressed both (CRC) tumor specimens mouse...