A5040796317- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Macrophage Migration Inhibitory Factor
- Drug Transport and Resistance Mechanisms
- Protein Tyrosine Phosphatases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Cancer therapeutics and mechanisms
- Neurological Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Circular RNAs in diseases
- Toxin Mechanisms and Immunotoxins
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
Shandong University
2016-2025
People 's Hospital of Jilin Province
2025
First Hospital of China Medical University
2024
China Medical University
2024
State Key Laboratory of Microbial Technology
2021-2022
Shanxi Provincial Cancer Hospital
2012-2020
Hunan Xiangdian Test Research Institute (China)
2015
Beijing Tian Tan Hospital
2015
Capital Medical University
2015
Binzhou Medical University
2012
Formation of tumour cell aggregation/emboli prolongs the survival circulating cells in circulation, enhances their physical trapping micro-vasculature and thus increases metastatic spread cancer to remote sites.It shows here that presence galactoside-binding galectin-3, whose concentration is markedly increased blood circulation patients, homotypic aggregation under anchorage-independent conditions by interaction with oncofetal Thomsen-Friedenreich carbohydrate (Galbeta1,3GalNAcalpha-, TF)...
Abstract Adhesion of circulating tumor cells to the blood vessel endothelium is a critical step in cancer metastasis. We show this study that galectin-3, concentration which greatly increased circulation patients, increases cell adhesion macrovascular and microvascular endothelial under static flow conditions, transendothelial invasion, decreases latency experimental metastasis athymic mice. These effects galectin-3 are shown be consequence its interaction with cancer-associated MUC1, breaks...
Abstract Purpose: Adhesion of disseminating tumor cells to the blood vascular endothelium is a pivotal step in metastasis. Previous investigations have shown that galectin-3 concentrations are increased bloodstream patients with cancer and promotes adhesion vitro experimental metastasis vivo. This study determined levels galectin-1, -2, -3, -4, -8, -9 sera healthy people colon breast assessed influence these galectins on cancer-endothelium adhesion. Experimental Design: Serum auto–anti-MUC1...
Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced disease stages by time it is diagnosed, high recurrence rates and metastasis. In present study, we investigated effects of metformin (a safe anti‐diabetic drug) curcumin turmeric polyphenol extracted from rhizome Curcuma longa Linn.) on proliferation, apoptosis, invasion, metastasis, angiogenesis HCC in vitro vivo. It was found that co‐treatment could not only induce tumor cells into apoptosis through activating...
By targeting a new binding region at the interface between αβ-tubulin heterodimers colchicine site, we designed series of 7-substituted 1-methyl-1,4-dihydroindeno[1,2-c]pyrazoles as potential tubulin polymerization inhibitors. Among compounds synthesized, 2-(6-ethoxy-3-(3-ethoxyphenylamino)-1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-7-yloxy)acetamide 6a and 2-(6-ethoxy-3-(3-ethoxyphenylamino)-1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-7-yloxy)-N-hydroxyacetamide 6n showed noteworthy low...
Scope Although the previous trials of inflammation have indicated that morin hydrate (MO) hold considerable promise, understanding distinct mechanism MO against remains a challenge. Methods and results This study investigated effect in atherosclerosis ApoE−/− mice underlying cell signaling human umbilical vein endothelial cells (HUVECs). Administration significantly reduced serum lipid level, inflammatory cytokines (TNF-α ICAM-1), atherosclerotic plaque formation vivo. presence attenuated...
Sambutoxin, a representative derivative of 4-hydroxy-2-pyridone, was isolated from Hericium alpestre for the first time in this study. The possible correlation between sambutoxin-induced suppression tumor growth and its influence on cell-cycle arrest apoptosis investigated. effects sambutoxin reactive oxygen species (ROS) production, DNA damage, mitochondrial transmembrane potential, cell apoptosis, expression related proteins were evaluated. An vitro viability study demonstrated that could...
Resistance to breast cancer (BCa) chemotherapy severely hampers the patient's prognosis. MicroRNAs provide a potential therapeutic prospect for BCa. In this study, reversal function of microRNA34a (miR34a) on doxorubicin (Dox) resistance BCa and possible mechanism was investigated. We found that relative level miR34a significantly decreased in Dox-resistant cell MCF-7 (MCF-7/A) compared with Dox-sensitive cells. Transfection suppressed invasion, migration, adhesion MCF-7/A cells without...
A Novelly-Spatiotemporal Characterization of the Disease Course in MNU-Induced Retinitis Pigmentosa Model".This study offers valuable insights into retinal degeneration MNU-induced RP rat model, with a strong focus on spatiotemporal disease progression and microglial activation.The authors' use advanced imaging techniques is commendable.However, I would like to suggest few areas for further consideration.First, while model widely used, it does not fully replicate genetic heterogeneity human...
Numerous diseases, such as diabetic retinopathy and age-related macular degeneration, can lead to retinal neovascularization, which seriously impair the visual function potentially result in blindness. The presence of blood–retina barrier makes it challenging for ocularly administered drugs penetrate physiological barriers reach ocular posterior segments, including retina choroid. Herein, we developed an innovative bifunctional peptide, Tat-C-RP7, exhibits excellent penetration capabilities...