A5040226048- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Circadian rhythm and melatonin
- Photonic and Optical Devices
- Optical Network Technologies
- Advanced Fiber Optic Sensors
- Magneto-Optical Properties and Applications
- Natural product bioactivities and synthesis
- Advanced Fiber Laser Technologies
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advanced Photonic Communication Systems
- Computational Drug Discovery Methods
- Dietary Effects on Health
- Nanoparticle-Based Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Plant-based Medicinal Research
- Analytical Chemistry and Chromatography
- Biochemical and Molecular Research
- Neonatal Health and Biochemistry
- Photonic Crystal and Fiber Optics
- Glutathione Transferases and Polymorphisms
- Estrogen and related hormone effects
- Natural Antidiabetic Agents Studies
University of Electronic Science and Technology of China
2014-2025
Guangzhou University of Chinese Medicine
2021-2024
Tobacco Research Institute
2024
Jinan University
2014-2023
Chinese Academy of Sciences
2018-2022
First Affiliated Hospital of Jinan University
2022
Shenzhen Institutes of Advanced Technology
2018-2022
Yichun University
2021
Jinan University
2021
Beijing Chuiyangliu Hospital
2018-2019
The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here we show colon genes (including Rev-erbα) are dysregulated mice with DSS-induced colitis. In turn, disruption the exacerbates experimental Rev-erbα-deficient more sensitive to colitis, supporting a critical role disease development. Further, ablation causes activation Nlrp3 inflammasome mice. Cell-based experiments reveal inactivates mainly at priming stage. directly represses transcription through...
While growing evidence suggests that circadian clock and obesity are intertwined, the underlying mechanism is poorly understood.Here, we investigate how linked to obesity.Methods: Metabolomics profiling of WAT (white adipose tissue) samples was performed identify metabolites altered in obese model.mRNA levels were analyzed by qPCR assays.Proteins detected immunoblotting, immunofluorescence ELISA.ChIP luciferase reporter assays used epigenetic transcriptional regulation.Results: Obesity...
The role of intestine clock in energy homeostasis remains elusive. Here we show that mice with Bmal1 specifically deleted the (Bmal1iKO mice) have a normal phenotype on chow diet. However, high-fat diet (HFD), Bmal1iKO are protected against development obesity and related abnormalities such as hyperlipidemia fatty livers. These metabolic phenotypes attributed to impaired lipid resynthesis reduced fat secretion. Consistently, wild-type fed HFD during nighttime (with lower BMAL1 expression)...
Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf Pueraria Lobata extracts (MPE), group with significant hypoglycemic activities, achieve synergic effect. MPE-loaded SeNPs (MPE-SeNPs) were prepared through solvent diffusion/in situ reduction technique...
Blood vessels in the tumor periphery have high pericyte coverage and are resistant to vascular disrupting agents (VDAs). VDA treatment resistance leads a viable peripheral rim that contributes failure disease recurrence. Here, we provide evidence support hypothesis shifting target of VDAs from vessel endothelial cells pericytes disrupts rim, circumventing resistance. Through chemical engineering, developed Z-GP-DAVLBH (from tubulin-binding desacetylvinblastine monohydrazide [DAVLBH]) as...
Linear diaryliodonium salts are widely used as arylating reagents for C–C and C–X bond formation. Meanwhile, synthetic applications of cyclic iodoniums relatively rare although they offer the opportunity to set up reaction cascades. We demonstrate an atom step economical three-component involving diphenyleneiodoniums, alkynes, boronic acids, resulting in construction methylidenefluorenes a single operation. Our route enables facile access both symmetrical unsymmetrical methylidenefluorene...
We demonstrate effective four-wave mixing in a 2- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu{\rm m}$</tex></formula> microfiber attached onto graphene film by using two continuous-wave pump lasers at wavelengths near 1550 nm. With contact length of 10 mm between the and input powers 600 100 mW for pumps, we achieve conversion efficiency that varies from...
Niclosamide is an anthelmintic drug that also demonstrates great potential in fighting against cancers. However, parenteral delivery of niclosamide challenged due to its insoluble property. This study aimed develop injectable formulation for using nanocrystals. nanocrystals were prepared by wet media milling technique and characterized electronic microscopes, differential scanning calorimetry, powder X-ray diffractometry release, etc. The resulting Tween 80 as the stabilizer approximately...
The role of small heterodimer partner (SHP) in regulation xenobiotic detoxification remains elusive.Here, we uncover a critical for SHP circadian cytochromes P450 (CYPs) and drug-induced hepatotoxicity.Methods: mRNA protein levels CYPs the livers wild-type -/-mice were measured by quantitative real-time polymerase chain reaction Western blotting, respectively.Regulation CYP was investigated using luciferase reporter, mobility shift, chromatin immunoprecipitation, and/or...
The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range drugs.Here, we aimed to clarify the impact circadian clock on MRP2, determine molecular mechanisms for generation diurnal expression. Methods:The regulatory effects Bmal1 expression were assessed using intestine-specific knockout (Bmal1 iKO ) mice colon cancer cells.The relative mRNA protein levels determined by qPCR Western blotting, respectively.Everted gut sac, cell viability situ perfusion...
Abstract Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel critical role Bmal1 for circadian clock-controlled Cyp3a11 expression and metabolism. deficiency decreases mRNA, protein microsomal activity Cyp3a11, blunts their rhythms in mice. A screen regulators identifies two genes Dbp Hnf4α as potential regulatory mediators. Cell-based experiments confirm that activate transcription by binding to D-box DR1 element promoter, respectively. binds P1...
Background and Purpose Whether how circadian clock proteins regulate drug detoxification are not known. Here, we have assessed the effects of CLOCK (a core protein) on metabolism detoxification. Experimental Approach Regulation by protein drug‐metabolizing enzymes was using Clock knockout ( −/− ) mice Hepa‐1c1c7/AML‐12 cells. The relative mRNA levels were determined qPCR Western blotting respectively. Toxicity pharmacokinetic experiments performed with wild‐type after intraperitoneal...
Acute kidney injury (AKI) is a common and critical illness, resulting in severe morbidity high mortality. There considerable interest identifying novel molecular targets for management of AKI. We investigated the potential role circadian clock components Rev-erb-α/β regulation ferroptosis AKI.AKI model was established by treating mice with folic acid. Regulatory effects on AKI were determined using single-gene knockout (Rev-erb-α-/- Rev-erb-β-/- ) mice, incomplete double-knockout (icDKO,...
Abstract To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, uncover role of Rev-erbα in circadian regulation epileptic seizures. We first show up-regulation REV-ERBα/Rev-erbα brain tissues from patients with epilepsy and a mouse model. Ablation or pharmacological modulation mice decreases susceptibility acute chronic seizures, abolishes diurnal rhythmicity seizure severity, whereas activation increases animal...