A5115806616- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Plant-based Medicinal Research
- Medicinal Plants and Bioactive Compounds
- Muscle Physiology and Disorders
- Reproductive Biology and Fertility
- Growth Hormone and Insulin-like Growth Factors
- Computational Drug Discovery Methods
- Biofuel production and bioconversion
- Stress Responses and Cortisol
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Enzyme Production and Characterization
- Dietary Effects on Health
- Heme Oxygenase-1 and Carbon Monoxide
- Olfactory and Sensory Function Studies
- Rice Cultivation and Yield Improvement
- Diet and metabolism studies
- Tissue Engineering and Regenerative Medicine
- Neonatal Health and Biochemistry
- Genetics, Aging, and Longevity in Model Organisms
McGill University
2023-2025
University of Cambridge
2023-2025
The University of Sydney
2024
Anzac Research Institute
2024
Zhejiang A & F University
2023
Jinan University
2019-2020
Myostatin is a paracrine myokine that regulates muscle mass in variety of species, including humans. In this work, we report functional role for myostatin as an endocrine hormone directly promotes pituitary follicle-stimulating (FSH) synthesis and thereby ovarian function mice. Previously, FSH-stimulating was attributed to other members the transforming growth factor–β family, activins. Our results both challenge activin’s eponymous FSH establish unexpected axis between skeletal gland. data...
One in ten women their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN KISS ) neurons represent GnRH pulse generator are dysfunctional PCOS. We used here vivo GCaMP fiber photometry other approaches to examine behavior of two mouse models began peripubertal androgen (PPA) model PCOS but found had a...
Abstract Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel critical role Bmal1 for circadian clock-controlled Cyp3a11 expression and metabolism. deficiency decreases mRNA, protein microsomal activity Cyp3a11, blunts their rhythms in mice. A screen regulators identifies two genes Dbp Hnf4α as potential regulatory mediators. Cell-based experiments confirm that activate transcription by binding to D-box DR1 element promoter, respectively. binds P1...
The arcuate nucleus kisspeptin (ARNKISS) neurons represent the GnRH pulse generator that likely drives pulsatile gonadotropin secretion in all mammals. Using an improved GCaMP fiber photometry system enabling long-term continuous recordings, we aimed to establish a definitive profile of ARNKISS neuronal activity across murine estrous cycle. As noted previously, substantial reduction frequency neuron synchronization events (SEs) occurs on late proestrus and extends into estrus. SE amplitude...
The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of neural network controlling mammalian fertility. We used GCaMP fiber photometry to record population activity GnRH neuron distal projections in ventral arcuate nucleus where they merge before entering median eminence release into portal vasculature. Recordings freely behaving intact male and female mice revealed abrupt ~8 min duration increases that correlated perfectly with appearance a subsequent pulse...
Controlling bilirubin to a low level is necessary in physiology because of its severe neurotoxicity. Therefore, it great interest understand the regulatory mechanisms for homeostasis. In this study, we uncover critical role circadian clock regulation detoxification and Methods: The mRNA protein levels Bmal1 (a core gene), metabolic enzymes transporters were measured by qPCR Western blotting, respectively. Luciferase reporter, mobility shift chromatin immunoprecipitation used investigate...
Abstract Inter-organ communication is a major hallmark of health and often orchestrated by hormones released the anterior pituitary gland. Pituitary gonadotropes secrete follicle-stimulating hormone (FSH) luteinizing (LH) to regulate gonadal function control fertility. Whether FSH LH also act on organs other than gonads debated. Here, we find that gonadotrope depletion in adult female mice triggers profound hypogonadism, obesity, glucose intolerance, fatty liver, bone loss. The absence sex...
Abstract Myostatin is a paracrine myokine that regulates muscle mass in variety of species, including humans. Here, we report functional role for myostatin as an endocrine hormone directly promoting pituitary follicle-stimulating (FSH) synthesis and thereby ovarian function. Previously, this FSH-stimulating was attributed to other members the transforming growth factor β family, activins. The results both challenge activin’s eponymous FSH establish axis between skeletal gland. data also...
Storage proteins are essential for seed germination and seedling growth, as they provide an indispensable nitrogen source energy. Our previous report highlighted the defective endosperm development in serine hydroxymethyltransferase 4 (OsSHMT4) gene mutant, floury endosperm20-1 (flo20-1). However, alterations storage protein content distribution within flo20-1 remained unclear. Here, immunocytochemistry analyses revealed a deficiency accumulation flo20-1. Electron microscopic observation...
Abstract One in five women worldwide suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN KISS ) neurons represent GnRH pulse generator are dysfunctional PCOS. We used here vivo GCaMP fiber photometry other approaches to examine behavior of two mouse models began peripubertal androgen (PPA) model PCOS but found had a...
Abstract The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of neural network controlling mammalian fertility. We used GCaMP fiber photometry to record population activity GnRH neuron distal projections in ventral arcuate nucleus where they merge before entering median eminence release into portal vasculature. Recordings freely behaving intact male and female mice revealed abrupt ∼8-min duration increases that correlated perfectly with appearance a subsequent...
One in ten women their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN
One in five women worldwide suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN KISS ) neurons represent GnRH pulse generator are dysfunctional PCOS. We used here vivo GCaMP fiber photometry other approaches to examine behavior of two mouse models began peripubertal androgen (PPA) model PCOS but found had a reduction...
The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of neural network controlling mammalian fertility. We used GCaMP fiber photometry to record population activity GnRH neuron distal projections in ventral arcuate nucleus where they merge before entering median eminence release into portal vasculature. Recordings freely behaving intact male and female mice revealed abrupt 5-min duration increases that correlated perfectly with appearance a subsequent pulse...
The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of neural network controlling mammalian fertility. We used GCaMP fiber photometry to record population activity GnRH neuron distal projections in ventral arcuate nucleus where they merge before entering median eminence release into portal vasculature. Recordings freely behaving intact male and female mice revealed abrupt ~8 min duration increases that correlated perfectly with appearance a subsequent pulse...
The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of neural network controlling mammalian fertility. We used GCaMP fiber photometry to record population activity GnRH neuron distal projections in ventral arcuate nucleus where they merge before entering median eminence release into portal vasculature. Recordings freely behaving intact male and female mice revealed abrupt ∼8-min duration increases that correlated perfectly with appearance a subsequent pulse...
One in ten women their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN KISS ) neurons represent GnRH pulse generator are dysfunctional PCOS. We used here vivo GCaMP fiber photometry other approaches to examine behavior of two mouse models began peripubertal androgen (PPA) model PCOS but found had a...
Abstract Disclosure: Z. Zhou: None. M. Pardo-Navarro: S.Y. Han: A.E. Herbison: Up to one in five women worldwide suffer from polycystic ovary syndrome (PCOS), a condition typified by problems with fertility, high androgen levels, and altered metabolism. Primarily due the unknown aetiology of this disorder, limited strategies are available for PCOS treatment. The hypothalamic GnRH pulse generator is responsible driving pulsatile release LH control ovarian function. As patients show profound...