A5100717180- Electronic Packaging and Soldering Technologies
- Engineering Applied Research
- Biofuel production and bioconversion
- 3D IC and TSV technologies
- Fatigue and fracture mechanics
- Catalysis for Biomass Conversion
- Advanced Polymer Synthesis and Characterization
- Photopolymerization techniques and applications
- Advanced Welding Techniques Analysis
- Mechanical Behavior of Composites
- Lignin and Wood Chemistry
- Silicon Carbide Semiconductor Technologies
- Structural Behavior of Reinforced Concrete
- Microbial Metabolic Engineering and Bioproduction
- Concrete Properties and Behavior
- Aluminum Alloys Composites Properties
- Cytokine Signaling Pathways and Interactions
- Metallurgy and Material Forming
- Transportation Safety and Impact Analysis
- Solar Thermal and Photovoltaic Systems
- Advanced Surface Polishing Techniques
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Oral and Maxillofacial Pathology
Nanjing Medical University
2012-2025
Chinese Academy of Sciences
2016-2025
Dongfeng General Hospital
2008-2025
National Space Science Center
2021-2025
Agency for Science, Technology and Research
2015-2025
Genome Institute of Singapore
2012-2025
National University of Singapore
2012-2025
Duke-NUS Medical School
2012-2025
Hong Kong Polytechnic University
2024-2025
Shenzhen Institutes of Advanced Technology
2023-2025
Jasmonate (JA) and ethylene (ET) are two major plant hormones that synergistically regulate development tolerance to necrotrophic fungi. Both JA ET induce the expression of several pathogenesis-related genes, while blocking either signaling pathway abolishes induction these genes by alone or in combination. However, molecular basis JA/ET coaction interdependency is largely unknown. Here, we report Arabidopsis ET-stabilized transcription factors (EIN3 EIL1) integrate regulation gene...
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by loss oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), proinflammatory cytokine implicated in MS, can activate necroptosis, necrotic cell death pathway regulated RIPK1 RIPK3 under caspase-8-deficient conditions. Here, we demonstrate defective caspase-8 activation, as well activation RIPK1, RIPK3, MLKL, hallmark mediators cortical lesions human MS pathological samples. Furthermore,...
The segmental prestressed concrete box girder of Koror-Babeldaob (KB) Bridge in Palau, which had a record span 241 m (791 ft), presents striking paradigm serviceability loss because excessive multidecade deflections. data required for analysis have recently been released and are here exploited to show how the design could be improved. Erected segmentally 1977, this developed midspan deflection 1.61 (5.3 ft) compared with camber after 18 years, it collapsed 1996 as consequence remedial...
Flexible supercapacitors have recently attracted intense interest. However, achieving high energy density via practical materials and synthetic techniques is a major challenge. Here, we develop hetero-structured material made of black phosphorous that chemically bridged with carbon nanotubes. Using microfluidic-spinning technique, the hybrid phosphorous-carbon nanotubes are further assembled into non-woven fibre fabrics deliver performance as supercapacitor electrodes. The flexible exhibits...
Significance Accurate prediction of community responses to global change drivers (GCDs) is critical given the effects biodiversity on ecosystem services. There consensus that human activities are driving species extinctions at scale, but debate remains over whether GCDs systematically altering local communities worldwide. Across 105 experiments included 400 experimental manipulations, we found evidence for a lagged response herbaceous plant caused by shifts in identities and relative...
Abstract Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome 330 TNBC samples 149 paired normal tissues to construct large metabolomic atlas TNBC. Combining with previously established transcriptomic genomic data same cohort, we conducted comprehensive analysis linking genomics. classified TNBCs into three distinct subgroups: C1,...
Summary Stability is an important property of ecological systems, many which are experiencing increasing levels anthropogenic environmental changes. However, how these changes influence ecosystem stability remains poorly understood. We conducted 8‐year field experiment in a semi‐arid natural grassland to explore the effects two common changes, precipitation and nitrogen enrichment, on temporal plant above‐ground biomass. A split‐plot design, with as main plot factor subplot factor, was used....
Click to increase image sizeClick decrease sizeKey Words: clock mutantsactivity rhythmscourtship songP-element transformationSouthern and Northern blot analyses
In cohesive fracture of quasi-brittle materials such as concrete, rock, fiber composites, tough ceramics, rigid foams, sea ice, and wood, one can distinguish six simple easily modeled asymptotic cases: the behaviors very small large structures, structures failing at crack initiation from a smooth surface those with deep notch or preexisting crack, purely statistical Weibull-type size effect, energetic (deterministic) effect. Size effect laws governing transition between some these cases have...
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As a sequel to Part I, which clarified the causes of unexpectedly large deflections Koror-Babeldaob Bridge in Pacific island nation Palau, II presents numerical procedure and reviews lessons learned. The box girder represents thick shell that is discretized by eight-node, three-dimensional (3D) finite elements. Except for corrections due cracking, concrete creep assumed follow aging linear viscoelasticity modeled rate-type law based on Kelvin chain, properties are adjusted humidity...
Bioinspired methods allowing artificial actuators to perform controllably are potentially important for various principles and may offer fundamental insight into chemistry engineering. To date, the main challenges persist regarding achievement of large deformation in fast response-time potential-engineering applications which electrode materials structures limit ion diffusion accumulation processes. Herein, a novel electrochemical actuator is developed that presents both higher...
Nitrogen (N) enrichment resulting from anthropogenic activities has greatly changed the composition and functioning of soil communities. Nematodes are one most abundant diverse groups organisms, they occupy key trophic positions in detritus food web. have therefore been proposed as useful indicators for shifts ecosystem under N enrichment. Here, we monitored temporal dynamics nematode community using a multi-level addition experiment an Inner Mongolia grassland. Measurements were made three...
RIPK1 is a critical mediator of cell death and inflammation downstream TNFR1 upon stimulation by TNFα, potent proinflammatory cytokine involved in multitude human inflammatory degenerative diseases. contains an N-terminal kinase domain, intermediate C-terminal domain (DD). The activity promotes inflammation. Here, we investigated the involvement RIPK1-DD regulation activity. We show that charge-conserved mutation lysine located on surface DD (K599R or K584R murine RIPK1) blocks activation...