A5101776799- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Immune cells in cancer
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Synthetic Organic Chemistry Methods
- Inflammatory mediators and NSAID effects
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Circular RNAs in diseases
- interferon and immune responses
- Bioinformatics and Genomic Networks
- BRCA gene mutations in cancer
- MRI in cancer diagnosis
- Advanced Proteomics Techniques and Applications
Fudan University Shanghai Cancer Center
2017-2025
Shanghai Medical College of Fudan University
2018-2024
Peking University
2022-2024
Lanzhou University
2024
First Hospital of Lanzhou University
2024
Sichuan University
2022
Huazhong University of Science and Technology
2022
Chengdu University of Technology
2022
Cancer Institute (WIA)
2019
Abstract Purpose: The tumor microenvironment has a profound impact on prognosis and immunotherapy. However, the landscape of triple-negative breast cancer (TNBC) not been fully understood. Experimental Design: Using largest original multi-omics dataset TNBC (n = 386), we conducted an extensive immunogenomic analysis to explore heterogeneity prognostic significance microenvironment. We further analyzed potential immune escape mechanisms TNBC. Results: phenotypes were classified into three...
Abstract Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome 330 TNBC samples 149 paired normal tissues to construct large metabolomic atlas TNBC. Combining with previously established transcriptomic genomic data same cohort, we conducted comprehensive analysis linking genomics. classified TNBCs into three distinct subgroups: C1,...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of and lacks definite treatment targets. Tumor immune microenvironment (TIME) heterogeneity has a profound impact on immunotherapy response. Tumors with non-inflamed TIME derive limited benefit from immunotherapy. However, what drives formation in TNBC remains unclear.Using our multiomics database TNBC, we conducted an analysis to explore key genomic events driving TNBC. In vitro vivo studies further revealed potential...
Abstract Background Tumor-infiltrating lymphocytes (TILs) have become a promising biomarker for assessing tumor immune microenvironment and predicting immunotherapy response. However, the assessment of TILs relies on invasive pathological slides. Methods We retrospectively extracted radiomics features from magnetic resonance imaging (MRI) to develop radiomic cohort triple-negative breast cancer (TNBC) (n = 139), among which 116 patients underwent transcriptomic sequencing. This was randomly...
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous disease and lacks effective treatment. Our previous study classified TNBCs into four subtypes with putative therapeutic targets. Here, we report the final results of FUTURE, phase II umbrella trial designed to explore whether subtyping-based strategy may improve outcomes in metastatic TNBC patients. A total 141 patients median three lines therapies setting were enrolled seven parallel arms. Confirmed objective responses...
The molecular heterogeneity and distinct features of HER2-low breast cancers, particularly in the Chinese population, are not well understood, limiting its precise management era antibody‒drug conjugates. To address this issue, we established a cohort 434 patients with cancer (433 female one male) integrated genomic, transcriptomic, proteomic, metabolomic profiling data. In cohort, tumors more distinguished from HER2-0 hormone receptor-negative subgroup. Within tumors, significant...
Digital pathology allows computerized analysis of tumor ecosystem using whole slide images (WSIs). Here, we present single-cell morphological and topological profiling (sc-MTOP) to characterize by extracting the features nuclear morphology intercellular spatial relationship for individual cells. We construct a atlas comprising 410 million cells from 637 breast cancer WSIs dissect phenotypic diversity within tumor, inflammatory stroma respectively. Spatially-resolved identifies recurrent...
Regulatory T cells (Tregs) heavily infiltrate triple-negative breast cancer (TNBC), and their accumulation is affected by the metabolic reprogramming in cells. In present study, we sought to identify cell-intrinsic modulators correlating with Tregs infiltration TNBC.Using RNA-sequencing data from our institute (n=360) Molecular Taxonomy of Breast Cancer International Consortium TNBC cohort (n=320), calculated abundance each sample evaluated correlation between gene expression levels...
Background: Estrogen receptor-positive, progesterone and HER2-positive breast cancers (triple-positive cancers, TPBCs) account for 5% to 10% of all cancers.The clinical molecular features TPBCs remain elusive.In this study, we aim analyze the multiomics landscape responsiveness trastuzumab.Methods: We employed five cohorts.The first cohort was from Surveillance, Epidemiology, End Results database (n=32,056) used determine characteristics TPBC.The second, third fourth cohorts were The Cancer...
Abstract Background Although immunotherapy has achieved great progress in advanced triple-negative breast cancer (TNBC), there are still numerous patients who do not benefit from immunotherapy. Therefore, identification of the key molecule that induces immune escape and clarification its specific mechanism TNBC urgently needed. Methods In this research, single cell sequencing bulk were conducted for biomarker screening. Immunohistochemistry, multiplex immunofluorescence, orthotopic tumor...
The germline variant spectrum of triple-negative breast cancer (TNBC) is different from that other subtypes and has demonstrated ethnic differences. However, the variants TNBC among Chinese patients its clinical significance remain unclear.Using our multi-omics cohort (n = 325), we determined in aimed to illustrate their biological implications.Overall, 16.0% (52 325) harbored at least 1 pathogenic or likely variant. These were associated with early onset TNBC, occurrence contralateral...
The transcription variation, leading to various forms of transcripts and protein diversity, remains largely unexplored in triple-negative breast cancers (TNBCs). Here, we presented a comprehensive analysis RNA splicing cancer illustrate the biological function clinical implications tumor-specific (TSTs) arising from these junctions. Aberrant or TSTs were frequently harbored TNBC correlated with poor outcome. We discovered variant macrophage receptor collagenous structure–TST (MARCO-TST),...
Breast cancer is a highly heterogeneous disease with varied subtypes, prognoses and therapeutic responsiveness. Human leukocyte antigen class I (HLA-I) shapes the immunity thereby influences outcome of breast cancer. However, implications HLA-I variations in remain poorly understood. In this study, we established multiomics cohort 1156 Chinese patients for investigation. We calculated four important indicators each individual, including expression level, somatic loss heterozygosity (LOH),...
In order to investigate clinicopathological characteristics and prognosis of mixed invasive ductal lobular carcinoma (IDC-L), 209,109 primary breast cancer patients diagnosed with (IDC), (ILC) or IDC-L were included. It was found that had lower tumor grade higher hormone receptor positive proportions than IDC patients. Moreover, younger a similar status compared ILC Kaplan-Meier plots showed the cancer-specific survival (BCSS) significantly better (P < 0.001) tended be = 0.166). However,...