A5032873998- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Immune cells in cancer
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- RNA Research and Splicing
- Cancer, Stress, Anesthesia, and Immune Response
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2016-2025
Harbin Institute of Technology
2024
Ministry of Industry and Information Technology
2024
Shanghai Cancer Institute
2019-2024
Cancer Institute (WIA)
2015-2024
Guangzhou Medical University
2015-2024
Nanjing Agricultural University
2024
State Key Laboratory of Genetic Engineering
2024
Fudan University
2013-2024
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the orchestration metabolic pathways in regulating ferroptosis will provide new insights into TNBC therapeutic strategies. Here, we integrated multiomics data our large cohort (n = 465) to develop atlas. We discovered that TNBCs had heterogeneous phenotypes ferroptosis-related metabolites and pathways. The luminal androgen receptor (LAR) subtype was characterized by upregulation oxidized...
Abstract Purpose: The tumor microenvironment has a profound impact on prognosis and immunotherapy. However, the landscape of triple-negative breast cancer (TNBC) not been fully understood. Experimental Design: Using largest original multi-omics dataset TNBC (n = 386), we conducted an extensive immunogenomic analysis to explore heterogeneity prognostic significance microenvironment. We further analyzed potential immune escape mechanisms TNBC. Results: phenotypes were classified into three...
The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation tyrosine-828 residue in C-terminal cytoplasmic domain mediates direct interaction between phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting preferential activation PI3K/protein kinase B (Akt) pathway glioma (GSC) relative to matched nonstem cell. knockdown potently inhibits activity PI3K/Akt with an accompanying reduction...
Abstract Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome 330 TNBC samples 149 paired normal tissues to construct large metabolomic atlas TNBC. Combining with previously established transcriptomic genomic data same cohort, we conducted comprehensive analysis linking genomics. classified TNBCs into three distinct subgroups: C1,...
Abstract Background Molecular subtyping of triple-negative breast cancers (TNBCs) via gene expression profiling is essential for understanding the molecular essence this heterogeneous disease and guiding individualized treatment. We aim to devise a clinically practical method based on immunohistochemistry (IHC) TNBCs. Materials Methods By analyzing RNA sequencing data TNBCs from Fudan University Shanghai Cancer Center (FUSCC) (n = 360) The Genome Atlas set 158), we determined markers that...
Abstract Only a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor (ICI) targeting PD-1/PD-L1 signaling in combination chemotherapy. Here, we discovered that therapeutic response to ICI plus paclitaxel was associated subcellular redistribution PD-L1. In our immunotherapy cohort nab-paclitaxel, tumor samples responders showed significant distribution PD-L1 at mitochondria, while non-responders increased accumulation on cell membrane...
Intratumor heterogeneity (ITH) profoundly affects therapeutic responses and clinical outcomes. However, the widespread methods for assessing ITH based on genomic sequencing or pathological slides, which rely limited tissue samples, may lead to inaccuracies due potential sampling biases. Using a newly established multicenter breast cancer radio-multiomic dataset ( n = 1474) encompassing radiomic features extracted from dynamic contrast–enhanced magnetic resonance images, we formulated...
Triple-negative breast cancer (TNBC) is an aggressive subtype of with limited therapeutic options. IL1 receptor type 2 (IL1R2) promotes tumor-initiating cell (BTIC) self-renewal and tumor growth in TNBC, indicating that targeting it could improve patient treatment. In this study, we observed IL1R2 blockade strongly attenuated macrophage recruitment the polarization tumor-associated macrophages (TAM) to inhibit BTIC CD8+ T-cell exhaustion, which resulted reduced burden prolonged survival TNBC...
Hemodynamic disturbed flow (DF) is associated with susceptibility to atherosclerosis. Endothelial Kruppel-Like Factor 4 (KLF4) an important anti-inflammatory atheroprotective transcription factor that suppressed in regions of DF.The plasticity epigenomic KLF4 transcriptional regulation by flow-mediated DNA methylation was investigated vitro and arterial tissue.To recapitulate dominant characteristics atheroprotected atherosusceptible arteries, human aortic endothelial cells were subjected...
The growth arrest special 5 (GAS5) is known to be involved in various cancers. However, its expression regulation remains unclear. Polymorphisms the promoter region of GAS5 may affect and associated with cancer susceptibility. In this research, we first evaluated association a 5-base pair indel polymorphism (rs145204276) hepatocelluar carcinoma (HCC) susceptibility Chinese populations. Logistic regression analysis showed that deletion allele rs145204276 significantly increased risk HCC two...
Long non-coding RNAs (lncRNAs) play an important role in gene regulation and are involving diverse cellular processes. However, their roles reprogramming of expression profiles during lineage commitment maturation mesenchymal stem cells (MSCs) remain poorly understood. In the current study, we characterize a lncRNA, HoxA-AS3, differentiation MSCs. We showed that HoxA-AS3 is increased upon adipogenic induction MSCs, while remains unaltered osteogenic induction. Silencing MSCs resulted...
An emerging view regarding cancer metabolism is that it heterogeneous and context-specific, but remains to be elucidated in breast cancers. In this study, we characterized the energy-related metabolic features of cancers through integrative analyses multiple datasets with genomics, transcriptomics, metabolomics, single-cell transcriptome profiling. Energy-related signatures were used stratify tumors into two prognostic clusters: cluster 1 exhibits high glycolytic activity decreased survival...
Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all and have a sustained risk late disease recurrence. Cyclin-dependent kinase 4 6 (CDK4/6) inhibitors shown significant efficacy in ER+ cancer. However, their effects are still limited by drug resistance. In this study, we aim to explore the role long noncoding RNA TROJAN cancer.The expression level cancer tissue cell lines was determined quantitative real-time PCR. vitro vivo assays as well patient...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of and lacks definite treatment targets. Tumor immune microenvironment (TIME) heterogeneity has a profound impact on immunotherapy response. Tumors with non-inflamed TIME derive limited benefit from immunotherapy. However, what drives formation in TNBC remains unclear.Using our multiomics database TNBC, we conducted an analysis to explore key genomic events driving TNBC. In vitro vivo studies further revealed potential...