A5100398937- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Protein Tyrosine Phosphatases
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Biochemical and Molecular Research
- Estrogen and related hormone effects
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Acute Myeloid Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
Ningxia University
2022-2025
Harbin Medical University
2019-2025
Fourth Affiliated Hospital of Harbin Medical University
2019-2025
Sichuan Center for Disease Control and Prevention
2025
University of Electronic Science and Technology of China
2015-2025
Nanjing Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Xuzhou Children Hospital
2024
Wuhan University
2017-2024
Renmin Hospital of Wuhan University
2017-2024
Abstract Only a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor (ICI) targeting PD-1/PD-L1 signaling in combination chemotherapy. Here, we discovered that therapeutic response to ICI plus paclitaxel was associated subcellular redistribution PD-L1. In our immunotherapy cohort nab-paclitaxel, tumor samples responders showed significant distribution PD-L1 at mitochondria, while non-responders increased accumulation on cell membrane...
Deep venous thrombosis (DVT) of lower extremities is a common thrombotic disease, occurring either in isolation or as complication other diseases procedures. MiR-21 one important microRNAs which play critical role various cellular function. This study aim to determine the effect miR-21 on endothelial progenitor cells (EPCs) and its predicting prognosis DVT. EPCs was isolated from DVT models control subjects. expression confirmed by RT-PCR. Potential target mRNA predicted bioinformatics...
Unilateral ischemia reperfusion injury (UIRI) with longer time is associated an increased risk of acute renal and chronic kidney disease. Exosomes can transport lipid, protein, mRNA, miRNA to corresponding target cells mediate intercellular information exchange. In this study, we aimed investigate whether exosome-derived mediates epithelial-mesenchymal cell communication relevant fibrosis after UIRI. The secretion exosomes remarkably in the UIRI rat tubular epithelium (NRK-52E) hypoxia...
Purine nucleoside phosphorylase catalyzes reversible phosphorolysis of purine nucleosides and 2′-deoxypurine to the free base ribose (or 2′-deoxyribose) 1-phosphate. Whereas human enzyme is specific for 6-oxopurine ribonucleosides, Escherichia coli accepts additional substrates including 6-aminopurine a lesser extent arabinosides. These differences have been exploited in potential suicide gene therapy treatment solid tumors. In an effort optimize this approach, we determined...
Residual feed intake (RFI) is one of the indicators efficiency. To investigate microbial characteristics and differences in gastrointestinal tract beef cattle with different RFI, a metagenome methodology was used to explore rumen fecal microbiota 10 Qinchuan (five each extremely high low RFI groups). The results taxonomic annotation revealed that Bacteroidetes Firmicutes were most dominant phyla feces. Prevotella identified as potential biomarker LRFI group by LEfSe method, while...
Renal ischemia/reperfusion injury (RIRI) represents the principal factor underlying acute kidney (AKI), which primarily stems from cellular injuries and ferroptosis caused by reactive oxygen species (ROS). Salidroside (SA), an antioxidant natural ester, has been attributed with potential to protect against RIRI. In present study, rats received daily SA doses (1, 10, or 100 mg/kg) gavage for 7 consecutive days before surgery. The results revealed aggravated renal in RIRI group, was...
Butyrate contributes epigenetically to the changes in cellular function and tissue development of rumen ruminant animals, which might be achieved by its genetic or epigenetic regulation gene expression. To explore role butyrate on bovine epithelial development, this study characterized genome-wide H3K27ac modification super-enhancer profiles primary cells (REPC) induced with ChIP-seq, analyzed effects expression functional pathways integrating RNA-seq data. The results showed that...
Epstein-Barr virus is a human herpesvirus that causes infectious mononucleosis and lymphoproliferative malignancies. LMP1 (latent membrane protein-1), which encoded by this essential for transformation of B lymphocytes, acts as constitutively active mimic the tumor necrosis factor receptor (TNFR) CD40. an integral protein containing six transmembrane segments cytoplasmic domain at C terminus binds to intracellular TNFR-associated factors (TRAFs). TRAFs are co-inducers downstream signaling...
Histone deacetylase (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as α-tubulin. HDAC6 dysfunction is associated with several pathological conditions renal disorders, including UUO-induced fibrotic kidneys rhabdomyolysis-induced nephropathy. However, the role of ischemic acute kidney injury (AKI) mechanism by which inhibition protects tubular cells after AKI remain unclear. In present study, we observed that was markedly activated subjected to ischemia-...
Abstract Background Phosphorylation modification of BCL2 is involved in receptor activator nuclear factor-κB ligand (RANKL)-induced autophagy osteoclast precursors (OCPs) and osteoclastogenesis. As an antiapoptotic molecule, the role phosphorylation osteoclastogenesis unknown. This study aimed to explore how at specific sites regulates Methods We first examined effects RANKL on different (Ser70 Ser87) OCPs. In vivo, transgenic mice overexpressing (Tg-hRANKL mice) were used observe...
Cerebral ischemia-reperfusion (CIR) injury critically impacts stroke prognosis, yet effective therapeutic strategies remain limited. Irisin, an exercise-induced myokine, exhibits neuroprotective effects against cerebral ischemia. SIRT3, a mitochondrial deacetylase, is similarly implicated in mitigating injury. Given that irisin exerts protection via AMPK/PGC-1α pathway activation and SIRT3 acts downstream of PGC-1α , we hypothesized mediates irisin's neuroprotection CIR In vivo was modeled...
The regulation of residual feed intake (RFI) in beef cattle involves brain-gut mechanisms due to the interaction between neural signals brain and hunger or satiety gut. RNA-Seq data contain an extensive resource untapped SNPs. Therefore, hypothalamic duodenal tissues from ten extreme RFI individuals were collected, transcriptome sequenced this study. All alignment combined according RFI, SNPs same group identified. A total 270,410 found high group, 255,120 low group. Most detected intronic...
Wagyu cattle are well-known for their rich marbling. Qinchuan have slower-depositing marbling than cattle. However, because of an increase in the consumer demand high-quality beef and increasingly stringent standards quality, improving grade has become particularly crucial. Therefore, we here considered castrated crossbred (crossed with cattle) as research subjects. Flavor substances longissimus dorsi muscle (LDM) A1 A5 grades were detected through headspace-solid-phase microextraction-gas...
Background: The purine biosynthetic pathway in procaryotes enlists eleven enzymes, six of which use ATP. Enzymes 5 and 6 this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) aminoimidazole (AIR) synthetase (PurM) utilize ATP to activate the oxygen an amide within their substrate toward nucleophilic attack by a nitrogen. AIR uses product PurL, formylglycinamidine (FGAM) make AIR, ADP Pi.Results: structure hexahistidine-tagged PurM has been solved multiwavelength...
The present study aimed to determine the expression of autophagy and investigate whether hypoxia‑inducible factor 1α (HIF‑1α)/BCL2 interacting protein (BNIP3)/Beclin‑1 signaling pathway serves an important role in activating varicocele (VC) rat testes cells. Furthermore, current explain possible association between apoptosis. A total 48 adult male Sprague Dawley rats were divided into group (control), B (VC 15‑day), C 30‑day) D 45‑day), with 12 each group. did not receive any interventions,...
Sodium butyrate (NaB) is one of the short-chain fatty acids and notably produced in large amounts from dietary fiber gut. Recent evidence suggests that NaB induces cell proliferation apoptosis. Skeletal muscle rich plenty mitochondrial. However, it unclear how acts on host cells whether involved mitochondria-related functions myocytes. The present study aimed to investigate role treatment proliferation, apoptosis, mitophagy bovine skeletal satellite (BSCs). results showed inhibited promoted...
Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role maintaining body's homeostasis. Epigenetic modification, specifically histone acetylation, serves as crucial regulatory mechanism influencing physiological processes and metabolic patterns within skeletal muscle metabolism. The intricate process of acetylation modification involves coordinated control acetyltransferase deacetylase levels, dynamically modulating precisely regulating...