A5100323588- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA Research and Splicing
- RNA regulation and disease
- Breast Cancer Treatment Studies
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Tree Root and Stability Studies
- Extracellular vesicles in disease
- Diet and metabolism studies
- Ga2O3 and related materials
- GaN-based semiconductor devices and materials
- Peroxisome Proliferator-Activated Receptors
- Cancer Immunotherapy and Biomarkers
- Gynecological conditions and treatments
- Kruppel-like factors research
- Agriculture, Soil, Plant Science
- Selenium in Biological Systems
- Cancer Genomics and Diagnostics
Guizhou Institute of Biology
2025
Shandong University
2024
Second Affiliated Hospital of Nanjing Medical University
2023
Hunan Academy of Agricultural Sciences
2018-2023
Tropical Crops Genetic Resources Institute
2023
Shanghai First People's Hospital
2023
Shanghai Jiao Tong University
2023
Tongji University
2023
Baker Heart and Diabetes Institute
2019-2023
First Affiliated Hospital of Kunming Medical University
2023
An emerging view regarding cancer metabolism is that it heterogeneous and context-specific, but remains to be elucidated in breast cancers. In this study, we characterized the energy-related metabolic features of cancers through integrative analyses multiple datasets with genomics, transcriptomics, metabolomics, single-cell transcriptome profiling. Energy-related signatures were used stratify tumors into two prognostic clusters: cluster 1 exhibits high glycolytic activity decreased survival...
A stem-like subpopulation existed in GBM cells, called glioma stem cells (GSCs), might contribute to cancer invasion, angiogenesis, immune evasion, and therapeutic resistance, providing a rationale eliminate GSCs population their supporting niche for successful treatment. LincRNA-p21, novel regulator of cell proliferation, apoptosis DNA damage response, is found be downregulated several types tumor. However, little known about the role lincRNA-p21 stemness radioresistance its regulating...
Astragalus polysaccharide (APS), a natural antioxidant found in membranaceus emerging as novel anticancer agent, exerts antiproliferative and pro-apoptotic activity various cancer cell types, but its effect on ovarian (OC) remains unknown. In the present study, we tried to elucidate role mechanism of APS OC cells. Our results showed that treatment suppressed proliferation induced apoptosis Afterward, microRNA (miRNA) profiles APS-treated cells were determined by microarray assay, whether...
Abstract The development of nephrotoxicity largely limits the clinical use chemotherapy. MiRNAs are able to target various genes and involved in regulation diverse cellular processes, including cell apoptosis death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) treatment renal mesangial cells kidney tissue, which associated with decreased baculoviral inhibition protein repeat-containing 6 (BIRC6) apoptotic rate. Enforced enhanced...
Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles directing reprogramming. To investigate the effect GSK3 inhibitors on miRNA expression, we analysed expression profile J1 mESCs absence or presence CHIR99021 (CHIR) 6-bromoindirubin-3'-oxime (BIO) by small RNA deep-sequencing. The results demonstrate that CHIR BIO decrease mature miRNAs most species, 90.4% 98.1%...
Recent evidence suggests that dysregulation of microRNAs is associated with the development multiple malignancies. miR-186 has been reported as a critical cancer regulator in several types cancers. However, its functional significance and molecular mechanism underlying renal cell carcinoma (RCC) remain unknown. In this study, our results showed expression was dramatically downregulated RCC tissues lines compared to adjacent normal lines. Overexpression significantly inhibited growth, colony...
Leaf abscission of Cyclocarya paliurus stem segments in vitro is very serious, and more than 90% the leaves gradually fall off with prolonged culture time, which hinders breeding. This study investigated molecular mechanism leaf abscission. The emerged C. were cultured for 22 days (T0) vitro; at 27 (T1) that had fallen after ≥ 32 (T2) used as materials analysis physiological characteristics transcriptome data. During process paliurus, Indole-3-acetic acid (IAA) content decreased, whereas...
Abstract Background Luminal B cancers show much worse outcomes compared to luminal A. This present study aims screen key lncRNAs and mRNAs correlated with luminal-B breast cancer. Methods Luminal-B cancer tissue samples adjacent were obtained from 4 patients To obtain differentially expressed (DEmRNAs) (DElncRNAs) between tumor tissues tissues, RNA-sequencing bioinformatics analysis performed. Functional annotation of DEmRNAs protein-protein interaction networks (PPI) construction...
This study evaluated the effects of flavonoids from mulberry leaves (FML) on plasma biochemical indices, serum activities lipid metabolism-related enzymes, fat morphology, fatty acid composition, and metabolism in different adipose tissues finishing pigs. We used 120 Chinese hybrid barrows Berkshire Bama mini-pigs with an average initial body weight 45.11 ± 4.23 kg. The pigs were randomly assigned to five treatment groups fed a control diet based corn, soybean meal, wheat bran or...
Cell migration is orchestrated by dynamic interactions of microtubules with the plasma membrane cortex. How these facilitate processes still being actively investigated. TIP150 a newly characterized microtubule plus end tracking protein essential for mitosis and entosis (Ward, T., Wang, M., Liu, X., Z., Xia, P., Chu, Y., L., Jiang, K., Yu, H., Yan, J., Hill, D. Huang, Zhu, Yao, X. (2013) Regulation interaction between two microtubule-binding proteins, EB1 TIP150, mitotic p300/CBP-associated...
Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including heart. The lncRNA OIP5-AS1 (1700020I14Rik/Cyrano) has studied several settings; however its role cardiac pathologies remains mostly uncharacterized. Using a series vitro ex vivo methods, we demonstrate that is regulated during development rodent human models disease settings mice. CRISPR,...
Abstract Long ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We others previously established that lncRNA Oip5os1 ( 1700020I14Rik , OIP5‐AS1, Cyrano) is enriched striated muscles, its deletion mice leads defects both skeletal cardiac muscle function. In present study, we investigated impact of global on function setting streptozotocin (STZ)‐induced diabetes. Specifically, studied male WT KO with or without diabetes for 24...
Accumulating evidence have suggested that long non-coding RNAs (lncRNAs) act as a critical regulator in tumorgenesis. LncRNA KCNQ1OT1 (KCNQ1OT1) has been recently shown to be dysregulated many cancers. This study was aimed explore the biological role of hepatocellular carcinoma (HCC). In our study, we first observed expression level distinctly up-regulated HCC tissues and cell lines compared with adjacent non-cancer normal liver line. And clinical results indicated higher correlated poor...
Purpose: LncRNAs play an important role in tumorigenesis and cancer progression liver cancer. Although many lncRNAs have been reported, the of MIR194-2HG underlying mechanism mediated by it are still largely unknown HCC. This study aimed to investigate biological Materials Methods: The expression was determined tissues cells RT-qPCR. overall survival rate analyzed Kaplan–Meier analysis. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation, Transwell assays...
Glioblastoma (GBM) is the most prevalent and malignant brain tumor highly resistant to currently available treatment. In this study, we reveal that polypeptide N-acetylgalactosaminyltransferase 5 (GALNT2) expression level was elevated in GBM, IDH1 wildtype glioma, GBM stem cells (GSCs). GALNT2 increased correlated with patients' unfavorable clinical outcomes. Functionally, targeting blocks GSCs cell proliferation, self-renewal, invasion through repressing CD44 expression. Most importantly,...