A5101795292- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Macrophage Migration Inhibitory Factor
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Pregnancy-related medical research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Ion channel regulation and function
- RNA Research and Splicing
- Nitric Oxide and Endothelin Effects
- S100 Proteins and Annexins
- Histone Deacetylase Inhibitors Research
- Cardiovascular Effects of Exercise
- Coenzyme Q10 studies and effects
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Advanced battery technologies research
- Advanced Battery Technologies Research
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
Xi'an Jiaotong University
2018-2025
Baker Heart and Diabetes Institute
2016-2025
Institute of Experimental Cardiology
2013-2021
Shengli Oilfield Central Hospital
2021
Monash University
2010-2019
Xiaomi (China)
2015-2019
Peking University
2018
Ministry of Education of the People's Republic of China
2018
Peking University Third Hospital
2018
Daping Hospital
2016
High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, diet poor in fiber is associated with prevalence of high BP. The impact lack prebiotic and the mechanisms that lead higher BP are unknown. Here we show dietary leads development hypertensinogenic gut microbiota, hypertension its complications, demonstrate role G-protein coupled-receptors (GPCRs) sense metabolites.One hundred...
Highlights•IL-6 trans-signaling recruits macrophages to adipose tissue in HFD-induced obesity•Blocking IL-6 with sgp130Fc prevents ATM accumulation•Prevention of accumulation obesity does not rescue insulin resistance•Blocking exacerbate resistanceSummaryInterleukin-6 (IL-6) plays a paradoxical role inflammation and metabolism. The pro-inflammatory effects are mediated via "trans-signaling," process where the soluble form receptor (sIL-6R) binds activates signaling inflammatory cells that...
The antifibrotic effects of the peptide hormone relaxin on cardiac and renal fibrosis were studied in 9- to 10-month-old male spontaneously hypertensive rats (SHR) normotensive Wistar-Kyoto (WKY). Rats (n=8 9 per group) allocated into 3 groups: WKY controls, vehicle-treated SHR (SHR-V), relaxin-treated (SHR-R). Relaxin (0.5 mg/kg day) was administered via subcutaneously implanted osmotic mini-pumps over 2 weeks before hearts kidneys harvested for analysis. Collagen content analyzed by...
Objective— Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. Activation phosphoinositide 3-kinase [PI3K(p110α)] considered new strategy for the treatment However, whether PI3K(p110α) provides protection in setting MI unknown, and difficult target because it has multiple actions numerous cell types. The goal this study was assess beneficial and, if so, identify cardiac-selective microRNA mRNA that...
Background— Numerous molecular and biochemical changes have been linked with the cardioprotective effects of exercise, including increases in antioxidant enzymes, heat shock proteins, regulators cardiac myocyte proliferation. However, a master regulator exercise-induced protection has yet to be identified. Here, we assess whether phosphoinositide 3-kinase (PI3K) p110α is essential for mediating cardioprotection, if so, its activation independent exercise can restore function failing heart....
Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct targets remain poorly characterized. Since inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized acetylation would target genes implicated in remodeling. Trichostatin A (TSA) regulates expression attenuates transverse aortic constriction (TAC) induced hypertrophy. We used chromatin immunoprecipitation (ChIP)...
Rationale: Chemotherapy is a common clinical strategy for cancer treatment.However, the accompanied cardiomyopathy renders patients under risk of another life-threatening condition.Whereas Hippo pathway known to play key roles in both cancerogenesis and heart disease, it remains unclear whether activation mediates chemotherapy-induced cardiomyopathy.Methods Results: In human breast cells, doxorubicin (DOX) significantly induced upregulation kinase Mst1, inhibitory phosphorylation YAP,...
Objective: To investigate cardiac phenotypes in mice deficient the peptide hormone relaxin by gene targeting. Methods: Echocardiography and catheterization were performed on male female (Rlx−/−) as well heterozygous (Rlx+/−) wildtype (Rlx+/+) littermates aged between 8 24 months. Collagen expression content heart analysed real-time PCR, hydroxyproline assay histology. Results: Heart rate, blood pressures, left ventricular (LV) dimensions, fractional shortening maximal minimal dP/dt did not...
Abstract —Maintenance of cardiac performance is tightly controlled by the autonomic nervous system. In congestive heart failure (CHF), although adverse pathophysiological effects sympathetic overactivity are increasingly recognized, paradoxical finding reduced innervation density in failing remains unexplained. Given these observations, we tested hypothesis that a reduction myocardial production nerve growth factor (NGF), which important for maintenance neuronal survival, could explain...
The goal of this study was to investigate the role platelets in systemic and cardiac inflammatory responses development postinfarct ventricular complications, as well efficacy antiplatelet interventions.Using a mouse myocardial infarction (MI) model, we determined platelet accumulation severity inflammation within infarcted myocardium by immunohistochemistry biochemical assays, analyzed peripheral blood platelet-leukocyte conjugation using flow cytometry, tested interventions, including...
1 Ketamine and xylazine (KX) mixture is the most commonly used anaesthetic drug during echocardiography in mice to induce sedation immobility. Nevertheless, doses of KX reported literature vary substantially with associated significant difference cardiac function. To explore optimal dosage observation time for murine echocardiography, we compared effects various combinations on echocardiographic measurement. 2 Mice were anaesthetized ketamine (50 or 100 mg/kg) (0–10 mg/kg). Echocardiography...
HDAC inhibitors can regulate gene expression by post-translational modification of histone as well nonhistone proteins. Often studied at single loci, increased acetylation is the paradigmatic mechanism action. However, little known extent genome-wide changes in cells stimulated hydroxamic acids, TSA and SAHA. In this article, we map vascular chromatin modifications including H3 lysine 9 14 (H3K9/14ac) using immunoprecipitation (ChIP) coupled with massive parallel sequencing (ChIP-seq). Since...